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Showing 1 to 20 of 34 for “"Cardiac fibroblasts"”.
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Role of extracellular environment in mechanical properties of human cardiac fibroblasts and myofibroblasts
… inhibits its contractile function and leads to a cardiac output loss. Cardiac fibroblast and myofibroblast cells are integral in the remodelling of injured tissue and are the most anticipated therapeutic target for cardiac fibrosis. To date, there is no anti-fibrotic therapy, which we argue, is …
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Determining if the Developmental Origin of Cardiac Fibroblasts Determines the Fate of Activation in Adult-Onset Hypertension
… worldwide, responsible for 1 in5 deaths, with cardiac fibrosis playing a critical role in heart failure progression [13, 18, 17]. Cardiac fibrosis, characterized by excessive extracellular matrix (ECM) deposition and tissue stiffening, impairs cardiac function, reducing contractility and …
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Defining the Developmental Signals of the Cardiac Fibroblast
Cardiac fibroblasts play a central role as a mediator of inflammatory and fibrotic response and also secrete extracellular matrix components that provide structural support for regeneration and remodeling of the wound. Despite the importance of the cardiac fibroblast in heart disease, very little …
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An in Vitro Study of Cellular Cardiomyoplasty: Structural and Functional Interactions of Non-cardiomyocytes and Cardiomyocytes
… structural and functional interactions between cardiac and non-cardiac cells is essential to better address the sequelae of cardiac disease and improve the potential cellular implantation therapies. First, an in vitro model was established to investigate the probability that electromechanical …
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Estrogen Modulation of Cardiac Immune Cells Is Cardioprotective.
… myocardium, suggesting estrogen may modulate the cardiac immune cells. The cardiac immune cells have been linked to adverse remodeling responses that occurs secondary to chronic volume overload. Therefore, to test if estrogen was modulating the cardiac immune cells; the cardiac immune cells of …
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The role of Nox2 containing NADPH oxidase in hypertensive heart disease
… reported to be involved in the development of cardiac hypertrophy and fibrosis. However the relevant cellular source(s) involved in the above effects remains unclear. The aim of this thesis was to investigate the critical cell source of the Nox2 in a model of angiotensin II (AngII) induced left …
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Regulation of Cardiac Fibroblast and Coronary Vascular Smooth Muscle Development by Platelet Derived Growth Factor Receptors
Coronary vascular smooth muscle cells (cVSMC) and cardiac fibroblasts are essential for coronary artery development and are important mediators of myocardial pathogenesis. These cells form when a subset of epicardial cells undergoes an epithelial-to-mesenchymal transition (EMT) and migrates into …
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Role of Dopamine Receptor 3 in Cardiac Fibrosis
… We hypothesized that there is an intrinsic cardiac dopaminergic system and changes to that system can lead to left ventricular (LV) remodeling and particularly, cardiac fibrosis. The first aim focused on determining the relative gene expression of all five dopamine receptors in both wild …
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Biomimetic approach to cardiac tissue engineering
… Finally, in order to mimic capillary structure cardiac fibroblasts and myocytes were co-cultured on a scaffold with a parallel channel array that was perfused with culture medium supplemented with synthetic oxygen carrier (PFC emulsion). Presence of the PFC emulsion resulted in significantly …
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A MECHANISM FOR CORTICAL BONE STEM CELL-DERIVED EXOSOMES’ THERAPEUTIC EFFECT ON POST-MYOCARDIAL INFARCTION REPERFUSION INJURY AND CARDIAC REMODELING
… Myocardial infarction (MI) is followed by cardiac remodeling involving extensive fibrosis and which can ultimately progress into heart failure. Previous studies have shown both that both post-MI and post-ischemia reperfusion (I/R), there is a reduction in scar size and improved cardiac …
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PIEZO1 Channel-Mediated Mechanotransduction as a Driver of Cardiac Remodelling
… overload is a central driver of pathological cardiac hypertrophy and fibrosis, yet the mechanism linking mechanical cues to adverse remodelling remains unclear. Fibroblasts are major effector cells of fibrotic remodelling. Still, the precise mechanism by which fibroblasts decode biomechanical …
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Mechanical Deformation of the Extracellular Matrix Mediates Cellular Activation and Mechanotransduction
… strain and stress) is constantly applied to the cardiac extracellular matrix (ECM) at the cellular level (i.e. myocyte contraction and/or fibroblast focal adhesions) or globally through hemodynamic pressures. While mechanical load can be an important factor in maintaining tissue homeostasis, …
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Mechanical Property and Phenotype Characterization of an in vitro Model for Afterload-triggered Cardiac Hypertrophy
… has also revealed that conditions that increase cardiac afterload, like obesity and hypertension, worsen HCM patients’ prognosis. Among research models of HCM, in vitro models that use patient-derived induced pluripotent stem cell (iPSC) differentiated cardiomyocytes are especially promising …
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The Efficacy Of Prostaglandin Synthase Inhibition On Attenuating Pressure Overload Induced Cardiac Remodeling
… inflammation as the pathological driver of cardiac remodeling, the exact mechanistic pathway associated with pressure overload-induced cardiac remodeling remains to be elucidated. In order to address this issue, we designed this study to determine pathways associated with pressure overload …
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The Role of Angiotensin-(1-7) in the Modulation of Angiotensin II-Dependent Cardiac Remodeling
Cardiac remodeling with associated changes in myocardial structure and function occurs in response to injury to the heart concomitant with chronic hypertension. The structural changes to the heart, including myocyte and vascular hypertrophy as well as interstitial and perivascular fibrosis, are …
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DIRECT REPROGRAMMING OF HUMAN FIBROBLASTS INTO CARDIOMYOCYTES
Direct reprogramming of human fibroblasts into induced cardiomyocytes (iCMs) offers a potential therapeutic approach for cardiovascular disease yet hampered by low efficiency of human iCM generation. Here, we established an optimal culture condition by defining a chemically defined media (CDM). In …
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The Role of Transforming Growth Factor-Beta In Alcohol-Induced Cardiac Fibrosis
… of 1, 2, 4, 8, 12, and 14 weeks. Changes in cardiac physiology were assessed at respective time points via echocardiography. Additionally, the use of histological techniques, mRNA analysis, apoptosis determination, and immunohistochemistry were employed to determine the functional and …
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Corticosteroid hormone action in the cardiovascular system
… in isolated adult rat cardiomyocytes (CM) and cardiac fibroblasts (cFb). We have detected 11β-HSD1 expression and activity in CM and cFb where it facilitates glucocorticoid hormone action, whereas 11β-HSD2 was absent. We have shown differential gene regulation by aldosterone (Aldo) and …
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The Derivation of the Myocardial, Epicardial and Endocardial Lineages from Human Pluripotent Stem Cells
… of coronary vascular smooth muscle cells and cardiac fibroblasts and may promote remodeling of the heart after cardiac infarct in the adult. The endocardium is the specialized inner endothelial lining of the heart chamber and contributes to the formation of valves. The endocardium also exerts …
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