Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 56 for “"Cardiac dysfunction"”.
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Heart in Polycystic Kidney Disease is Characterized by Cardiac Dysfunction and Structural Deformation
… Structural and functional abnormalities of cardiac tissues and fibrosis-associated pathways were analyzed.</p> <p><strong>Results:</strong> Human PKD myocardium were infiltrated by inflammatory cells M1 and M2. Expressions of transforming growth factor (TGF-β<sub>1</sub>) and …
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Detecting subclinical anthracycline therapy related cardiac dysfunction in low income country (SATRACD study)
Introduction: Anthracycline therapy-related cardiac dysfunction (ATRCD) is the most common chemotherapy-induced cardiovascular toxicity. It begins with subclinical myocardial cell injury that can be detected using speckle tracking echocardiography (STE), together with Troponin-I. Limited …
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Sunitinib-Induced Cardiotoxicity Exposes Microvascular and Metabolic Derangements In The Failing Heart
<p>Cardiac dysfunction is one of the largest obstacles to effective cancer treatment. Not only do a growing number of cancer patients have significant cardiovascular risk factors at the time of diagnosis, but a number of targeted therapies can themselves cause cardiac dysfunction. These newer …
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Hypertrophic Cardiomyopathy: A Review of Clinical and Molecular Characteristics and Effects and A Clinical Case Study
… is considered the most common cause of sudden cardiac death in young athletes. Mutations of the myosin-binding protein C (cMyBP-C) have been targeted as one of the most prevalent causes of this disease, and the deactivating effects of such mutant forms on the quality control …
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Point-of-care ultrasound abnormalities in late onset severe preeclampsia: prevalence and association with serum albumin and brain natriuretic peptide
… interstitial edema, cerebral edema, and cardiac dysfunction. Laboratory markers of oncotic pressure (albumin) and cardiac dysfunction (brain natriuretic peptide [BNP]) may be abnormal, but the clinical application remains unclear. We investigated the prevalence of pulmonary interstitial …
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Cardiac cycle timing intervals in acute COVID-19 and recovered COVID-19 with sustained symptoms
… COVID-19 can result in both acute and sustained cardiac damage. Acute cardiac damage may be due to elevated inflammatory responses and can result in ischemia, which can lead to impairments in the cardiac cycle timing events. The purpose of this project was threefold: 1) to characterise cardiac …
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Hepatic and Extra-hepatic Metabolism in NAFLD and the Role of Hepatocyte Oxygen Sensing
… metabolism were assessed alongside measures of cardiac, renal and whole-body health and metabolism. Hepatic *Epas1* deletion did not protect against NAFLD, or GAN diet induced hyperglycaemia and hyperlipidaemia, but did ameliorate GAN induced hyperinsulinaemia. Moreover, hepatic *Epas1* deletion …
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Role of PERM1 in the Development of Insulin Resistance and Diabetic Cardiomyopathy During High-Fat Diet Feeding
… predominantly expressed in skeletal and cardiac muscle. Our group has previously demonstrated that PERM1 is downregulated in both human and mouse failing hearts, and that Perm1-knockout mice exhibit reduced cardiac contractility and energy reserve. However, the role of PERM1 in cardiac …
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Protection of Pifithrin-α and Melatonin against Doxorubicin-Induced Cardiotoxicity.
… doxorubicin caused a significant increase of cardiac cell apoptosis following injection (14.2 ± 1.1% for doxorubicin-5 d vs. 1.8 ± 0.12% for control, <em>P</em> < 0.01). Ribonuclease protection assays and Western blot analyses revealed that doxorubicin upregulated the p53-dependent genes Bax, …
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Identification and Characterization of the Role of REEP5 in Sarco-Endoplasmic Reticulum Formation, Maintenance, and Function in Cardiac Muscle
… that are conserved among eukaryotic species, cardiac-enriched, and have not been previously linked to a cardiac phenotype. These poorly annotated cardiac-enriched membrane proteins represent excellent candidates in follow-up studies aimed at elucidating the underlying molecular mechanisms of …
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Investigating the protective role of the natural hormone Melatonin, in reducing drug-induced cardiotoxicity in the therapy of chronic diseases
… mostly unresolved but involves interplay between cardiac structural and electrical remodelling, metabolic alterations, cell death and altered gene expression. Mitochondrial dysfunction and HF are common complications of chronic treatment from diverse groups of drugs, in particular anticancer drugs …
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Melatonin as a novel cardioprotective therapy in pulmonary hypertension
… that oxidative stress may trigger cardiovascular dysfunction associated with the disease. To date, there is no efficient therapy against PH and novel therapies are urgently needed. Melatonin is a powerful antioxidant that can confer benefit against ischemia-reperfusion injury and hypertension. We …
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Elucidation of Emergent Regional Mechanisms of Heart Muscle Dysfunction in the Mouse Model of Duchenne Muscular Dystrophy
<p>Cardiac dysfunction is a primary cause of mortality in Duchenne Muscular Dystrophy (DMD), potentially related to elevated cytosolic calcium. However, the regional versus global functional consequences of cellular calcium mishandling have not been defined in the whole heart. Here, we elucidate, …
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Cellular therapy for chronic heart failure: a key role for epicardial fibronectin
… therapy with hESC-epicardium could attenuate cardiac dysfunction in the chronically failing heart, underpinned by sizeable cardiac grafts, cardiomyocyte proliferation and maturation, together with a host-derived vascular supply. Notably, hESC-epicardium’s augmentation of cardiomyocyte …
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The Long Non-coding RNA Malat1 Regulates Inflammatory Cytokine Production in Chronic Diabetic Complications
… cells cultured with high glucose, and renal and cardiac tissue from diabetic mice showed increased inflammatory cytokine (eg. IL-6, IL1β, TNFα) production along with transient MALAT1 upregulation. This was confirmed by both transcript and protein analyses, and such changes were prevented in the …
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Study and Therapeutic Interference of T Cell Function in Pressure Overload-induced Heart Failure
… to identify and exploit better targets in cardiac inflammation so as to enable an immunotherapy of HF. We linked T cells with HF development in the gold-standard mouse model of HF and in human HF patients. We inhibited T cell function in vivo via T cell costimulation blockade, through …
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Role of T Lymphocyte Trafficking in Diabetic Cardiomyopathy
… characterized by myocardial fibrosis and cardiac dysfunction in diabetic patients. The resolution of myocardial fibrosis to improve cardiac function in diabetes is an active area of research. Notably, increased T lymphocyte infiltration into myocardium has been attributed to increased …
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Left ventricular function after ultra-distance triathlon : response is dependent on the cardiac loading conditions
… after the cessation of exercise may cause "cardiac fatigue". The studies that have shown post-exercise "cardiac fatigue" have not controlled for either preload or afterload or both, before and after exercise. These studies may rather have identified the effects of alterations in peripheral …
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Genetic approaches to studying coronary heart disease in SR-BI/apoE double knockout mice
… atherosclerosis, myocardial infarction, cardiac dysfunction and premature death. This model represents a unique system in which to study the two principal underlying mechanisms of atherosclerosis and CHD, inflammation and lipoprotein lipid metabolism. The first part of this thesis …
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