Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 38 for “"Cardiac development"”.
-
Transcriptional Profiling of Early Cardiac Development
… intricate process that spans nearly the entire developmental history of the mammal. A thorough comprehension of the molecular interactions that direct cardiac development will improve our ability to understand and treat cardiovascular diseases. The earliest stages of heart development are of …
-
Proepicardial Cell Differentiation During Cardiac Development
<p> Epicardial cells have an emerging role as cardiac stem cells. These cells and their progenitors, proepicardial (PE) cells, have been recently shown to give rise to all resident cell types in the heart. The contribution of PE-derived cells to the development of atrioventricular (AV) valves and …
-
Akirin-Mediated Gene Regulation During Cardiac Development
… transcription factor activity during muscle development in <em>Drosophila melanogaster</em>. Akirin mediates an interaction between the Twist transcription factor and the multisubunit Brahma SWI/SNF-class chromatin remodeling complex at control elements of the <em>Dmef2</em> locus to maintain …
-
Investigating microRNAs during cardiac development in the chick
… that are known to be essential for the heart development of many organisms4,5. A miRNA becomes incorporated into the miRNA-induced silencing complex, which binds to a target mRNA transcript and inhibits its translation. Dysregulation of miRNAs is associated with failing human hearts6. More …
-
Zebrafish Cardiac Development Requires a Conserved Secondary Heart Field
… The secondary heart field (SHF) is a conserved developmental domain in avian and mammalian embryos that contributes myocardium and smooth muscle to the cardiac arterial pole. This field is part of the overall heart field, and its myocardial component has been fate mapped from the mesoderm to the …
-
Cell Migration and Survival Pathways in Cardiac Development and Disease
The file named "saxenaankur.pdf" is the primary dissertation file. All other files ("*.asf", "*.avi") are supplemental files and may be viewed individually.
-
Post-transcriptional regulation of poly(A) binding proteins direct multiple facets of cardiac development and hypertrophy
… the progression to heart failure is pathologic cardiac hypertrophy: the heart increases its size in response to a variety of prolonged, external stimuli. Similar to maturational hypertrophy, cellular hypertrophy of existing cardiomyocytes is responsible for the increase in size of the heart …
-
BUBR1 in Cardiac Biology: From Cardiogenesis to Adult Heart Function and Aging
Congenital heart defects and cardiac diseases associated with aging such as heart failure are leading contributors to morbidity and mortality worldwide, yet their underlying molecular mechanisms remain incompletely understood. This dissertation investigates the role of BubR1, a mitotic checkpoint …
-
Perinatal Hypoxia Exposure on the Developing Heart: The Role of Endothelin-1
… for cardiovascular disease. Therefore proper cardiac development is imperative in optimizing cardiac function throughout life. A key process in determining</p> <p>cardiomyocyte endowment, and thus cardiac function, is the period of terminal differentiation. This involves the maturation of …
-
LONG NON-CODING RNA VENTHEART IS NECESSARY FOR VENTRICULAR CARDIOMYOCYTE SPECIFICATION AND FUNCTION
Cardiac development is tightly regulated by various modulators including long non-coding RNAs (lncRNAs), which influence gene expression and cardiac cell fate. This thesis focuses on verifying and characterizing of one key lncRNA, VENTHEART (VHRT), which was identified as one of the top upregulated …
-
Biomimetic electrical stimulation for cardiac tissue engineering
… to induce synchronous contractions of cultured cardiac constructs. The hypothesis adopted for this study is that functional cardiac constructs can be engineered by "mimicking" the conditions present during cardiac development, and in particular, electrical stimulation using supra-threshold …
-
Control of Cardiac and Limb Development by the bHLH Transcription Factors DHAND and eHAND
… of multiple cell lineages during embryonic development. The bHLH proteins dHAND and eHAND are expressed in complimentary and overlapping patterns during embryogenesis, and gene knockout studies have demonstrated that dHAND and eHAND null embryos die from defects in right ventricular and …
-
Simulation of the Interaction Between Striated Muscle UNC-45 and Transcription Factor GATA-4
… protein that acts as a chaperone for myosin in cardiac and skeletal muscles, binding to myosin at its C-terminal UCS domain and regulating its assembly into thick filaments and sarcomeric structures. The UCS domain contains a large loop that is believed to be the first point of interaction …
-
Cellular and Molecular Mechanisms of Cardiac Chamber Maturation in Zebrafish
… formation of the heart is a critical part of development that, if defective, can lead to congenital malformations incompatible with life. An improved understanding of the cellular and molecular processes that build the heart is essential to elucidate the causes of congenital defects and to …
-
Developmental physiology of the red swamp crayfish Procambarus clarkii
… an understanding of the temporal sequence of cardiac regulatory mechanisms throughout the development of the red swamp crayfish Procambarus clarkii. Investigations focused on cardiac development and the ontogeny of the regulatory mechanisms of the cardiovascular system. Investigations …
-
Defining a Novel Role for the E3 Ubiquitin Ligase Wwp1 in Cardiac Arrhythmogenesis
<p>Sudden cardiac death (SCD) is the most common cause of mortality worldwide, accounting for more than 3 million deaths annually with estimates in the United States ranging between 300,000 to 350,000 deaths each year. Because SCD is the common endpoint of a variety of heart pathologies that …
-
Analysis of Band 4.1B In Integrin-Mediated Cell Adhesion and Signaling
… and Band 4.1B genes resulted in impaired cardiac morphogenesis, leading to embryonic lethality by E11.5. These embryos displayed malformation of the outflow tract that was likely linked to abnormal regulation of cardiac neural crest migration. These data indicate the importance of …
-
BNC1 Regulates Human Epicardial Heterogeneity and Function
… the heart, crucial to correct cardiovascular development. Following epithelial-to-mesenchymal transition (EMT), epicardial cells migrate into myocardium, form coronary smooth muscle cells and cardiac fibroblasts, and instruct cardiomyocytes to proliferate and mature. Adult mammalian epicardium …
-
Effect of Inflammation in Pregnancy on Maternal and Offspring Cardiovascular Systems
… and subsequent high fat diet consumption on cardiac function, morphology, and biomarkers of CVD in mothers and offspring. In the maternal study, pregnant C57BL/6 mice were injected intraperitoneally (i.p.) with lipopolysaccharide (LPS, 50 µg/kg) to induce complete fetal loss on gestational …
Page 1 of 2