Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Cardiac Toxicity"”.
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Microfuidic Devices and Open Access Tool for Localized Microinjection and Heart Monitoring of Drosophila Melanogaster
… use of Drosophila larvae as an in-vivo model for cardiac toxicity and cardiac gene screening. In objective 1, we have developed a hybrid multi-tasking microfluidic platform that enables desired orientation, reversible immobilization, and localized microinjection of intact Drosophila larvae for …
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Quantitative Comparison of Late Effects Following Photon Versus Proton External-Beam Radiation Therapies: to ward An Evidence-Based Approach to Selecting A Treatment Modality
… risk of radiogenic second cancer and cardiac toxicity based on the calculated doses and on dose-risk models from the literature; to test for the statistical significance of the difference between predicted risks after photon <em>versus</em> proton radiotherapies; and to provide a …
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Biochemical Thermodynamic Modelling of Cellular Bioenergetics: A Quantitative Systems Pharmacology Approach
… via redox cycling is an understated mechanism of toxicity associated with many classes of drugs. In particular, oxidative stress as a result of redox cycling plays a pivotal role in the cause of cardiac toxicity. For example, doxorubicin is an anti-neoplastic drug used to treat cancer. It has …
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The Role of MCL-1 in the Heart: Gateway from Life to Death
… of multiple cellular lineages, but its role in cardiac muscle has remained unclear. Here, we have demonstrated that cardiac-specific ablation of Mcl-1 results in a rapidly fatal, dilated cardiomyopathy preceded by loss of myofibrils and cardiac contractility, abnormal mitochondria …
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Cheaper Than A Funeral: Considering Ibogaine’s Psychedelic Journey and Therapeutic Potential
… still remain about whether or not ibogaine’s cardiac toxicity can effectively be managed in human patients, as well as the true therapeutic utility of the prolonged period of dreamlike consciousness ibogaine produces in patients. This thesis examines the cases of three patients–all United …
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Later Life Consequences of Subteratogenic Exposure to a Complex PAH Mixture in the Atlantic Killifish (Fundulus heteroclitus)
… Acute embryonic exposure to PAHs results in cardiac teratogenesis in fish, and early life exposure to certain individual PAHs and PAH mixtures cause heart alterations with decreased swimming capacity in adult fish. Consequently, the heart and cardiorespiratory system are thought to be targets …
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Dendrimer Nanoconjugates And Their Oral Inhalation Formulations For Lung Cancer Therapy
… issue is further complicated by dose-limiting toxicity of DOX. Another major challenge in the use of DOX is its cardiac toxicity. Free DOX in bloodstream can accumulate in cardiac tissues, thus leading to fatal heart damages. On the other hand, the lungs are considered as a portal to external …
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The Mechanism of Action of Lidocaine and Levobupivacaine on Human Cardiac Voltage-gated Na<sup>+ </sup>Channels Na<sub>V</sub>1.5
… inhibition by local anaesthetics, including the cardiac NaV1.5 subtype, which is also expressed in metastatic breast and colon cancer cells. The expression and function of NaV1.5 facilitate invasion and migration of colon cancer cells. Local anaesthetics inhibit metastatic cancer cell invasion in …
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Biochemical effects of organophosphorous compounds on cultured rat and human cardiomyocyte-like cells
… which has the ability to differentiate into a cardiac muscle phenotype, can be instrumental in understanding OP cytotoxicity at different differentiation stages. Human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) were used for the validation of selected OP effects in a more …
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Artificial Intelligence (AI)-assisted Cardiotoxicity Management in Lung Cancer Radiotherapy
… of treatment. However, radiation-induced cardiotoxicity has emerged as a significant long-term complication, impacting patient survival and quality of life. There is increasing evidence that post-radiotherapy cardiotoxicity is better indicated by cardiac substructure dose, compared with whole …
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Infrastructure Development For Personalized Risk Prediction to Reduce Cardiovascular Disease In Childhood Cancer Survivors
… morbidity and mortality for these survivors is cardiac disease. Radiation therapy (RT) has been linked in numerous cohort studies to a higher chance of developing a late cardiac disease in these survivors, and this risk rises with higher mean heart doses and increased RT exposure to larger …