Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 96 for “"Cardiac Tissue"”.
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Cardiac tissue engineering : bioreactor cultivation parameters
Tissue engineering may be useful in fighting heart disease since it offers the possibility of creating functional tissue equivalents for scientific studies and tissue repair. In the present work, we examined how variations in cultivation parameters of a model tissue engineering system influenced …
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Biomimetic approach to cardiac tissue engineering
… Finally, in order to mimic capillary structure cardiac fibroblasts and myocytes were co-cultured on a scaffold with a parallel channel array that was perfused with culture medium supplemented with synthetic oxygen carrier (PFC emulsion). Presence of the PFC emulsion resulted in significantly …
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Biomimetic electrical stimulation for cardiac tissue engineering
A major challenge of tissue engineering is directing cells to establish the physiological structure and function of the tissue being replaced. Electrical stimulation has been used to induce synchronous contractions of cultured cardiac constructs. The hypothesis adopted for this study is that …
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Biosynthesis of polyhydroxyalkanoates for cardiac tissue engineering applications
As a result of the enormous clinical need, cardiac tissue engineering has become a prime focus of research within the field of tissue engineering. In this project, Poly(3- hydroxyoctanoate), P(3HO), a medium chain length (mcl-PHAs) biodegradable, biocompatible and elastomeric polyhydroxyalkanoate, …
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Peptide targeted imaging of neutrophil invasion in cardiac tissue
… can save what would otherwise be necrotic tissue; however, if sufficient time has elapsed, the reintroduction of blood flow to a now hypoxic environment may further harm otherwise healthy tissue. When deprived of oxygen for an extended period of time, the environment of the occluded vessel …
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The propagation of the action potential in cardiac tissue
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Aeronautics and Astronautics, 1988.
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Bioreactors and microbioreactors for electromechanical stimulation in cardiac tissue engineering
… culture systems for laboratory studies of cardiac tissue engineering, featuring controlled electrical, or combined electro-mechanical stimulation of the culture environment. In consideration of the different research interests involved at the diverse hierarchical levels,the work was …
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Growth, modelling and remodelling of cardiac tissue: a multiphase approach
… placed on the importance of the development of a cardiac analysis toolbox with functionality for pathophysiological analysis of the disease. Subsequently, in order to further the understanding of the mechanisms of the disease as linked to cardiomyocyte growth and remodelling of the microstructure, …
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Collagen scaffolds and injectable biopolymer gels for cardiac tissue engineering
… begun to shown promise for cell delivery for cardiac tissue engineering. Although various polymers and material forms have been explored, there is a need for: injectable gels that meet certain design specifications; a more indepth characterization of the scaffold properties; and a deeper …
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Effect of Maternal Hypoxia on the Cerebral and Cardiac Tissue Remodeling
… developing heart and resulted in the abnormal cardiac growth pattern and cardiomyocyte proliferation with the aberrant content of fibrillar collagen network in fetal and neonatal hearts. We further explored the direct effect of hypoxia on cardiomyocyte proliferation by using intact fetal hearts …
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A Discrete Monolayer Cardiac Tissue Model for Tissue Preparation Specific Modeling
… present novel methods for modeling a monolayer cardiac tissue and for estimating intracellular conductivities from an optical mapping. First, in the proposed method for modeling a monolayer of cardiac tissue, the factors governing cell shape, cell-to-cell coupling and the degree of cleft space …
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Acoustic Radiation Force Impulse-Driven Shear Wave Velocimetry in Cardiac Tissue
… mechanical waves in various biological tissues. The velocity of these waves is related to a medium's stiffness and thus can offer useful diagnostic information. Consequently, shear wave velocimetry has the potential to investigate cardiac disease states that manifest themselves as …
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Design of 3D bioengineered cardiac tissue models for advanced in vitro testing
L'abstract è presente nell'allegato / the abstract is in the attachment
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Production and Characterisation of Tissue-mimicking Collagen Scaffolds for Cardiac Tissue Engineering
The ideal scaffold for tissue engineering provides an architecture similar to natural tissue. For cardiac tissue repair, this three dimensional environment can be modelled on the myocardial extracellular matrix (ECM). To approximate the material composition of the ECM, collagen type I can be used, …
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Design, Production and Characterisation of Anisotropic Collagen Scaffolds for Cardiac Tissue Repair
… heart muscle wall contributes significantly to cardiac function. Recapitulating this complex structure *in vitro* is challenging and there has been limited success achieving this in tissue engineering scaffolds. Unidirectional ice-templating has been established in prior work and collagen …
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Development of a Micromorphic (Multiscale) Material Model aimed at Cardiac Tissue Mechanics
Computational cardiac mechanics has historically relied on classical continuum models; however, classical models amalgamate the behaviour of a material's micro-constituents, and thus only approximate the macroscopically observable material behaviour as a purely averaged response that originated on …
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Development of cardiac patches using medium chain length polyhydroxyalkanoates for cardiac tissue engineering
… that make them exceptional for applications in cardiac tissue engineering. Cardiovascular diseases (CVD) are a major cause of death worldwide. Cardiac patches aim to facilitate the normal functioning of the heart muscle by providing repair and support to the infarcted tissue post myocardial …
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Engineered hydrogels with biomimetic biochemical and physical signaling cues for cardiac tissue engineering
L'abstract è presente nell'allegato / the abstract is in the attachment
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Junctional Sarcoplasmic Reticulum Protein Processing And Trafficking In Cardiac Tissue And Primary Cultured Cardiomyocytes
… of an exclusive set of resident proteins. Cardiac calsequestrin (CSQ2) undergoes two co-translational modifications: N-linked glycosylation on 316Asn, and phosphorylation by protein kinase CK2 on a cluster of 3 serines in its tail. In the heart, CSQ2 molecules undergo extensive mannose …
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