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Showing 1 to 12 of 12 for “"Cardiac Physiology"”.
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Cardiac organoid technology and computational processing of cardiac physiology for advanced drug screening applications
… as the heart. Previous work in stem cell-derived cardiac tissue has exploited how we can engineer biologically functional heart tissue by providing the appropriate external stimuli to facilitate tissue development. The goal of this dissertation is to explore the potentials of stem cell cardiac …
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Interactive contributions of children’s negative or positive behavior and maternal cardiac physiology to parenting in real time: An integration of biology and context
… negative or positive behavior and maternal cardiac physiology in real time to three types of parenting behavior: maternal emotional support, maternal nonsupport, and maternal cognitive assistance. I utilized data collected from 130 mother-preschooler dyads (65 girls) during a 5-min …
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Materials and designs for 3D conformal electronics with capabilities in cardiac mapping and stimulation
… interfaces between medical electronics and cardiac structures. Here we present advanced materials, mechanical designs and fabrication approaches that yield classes of 3D conformal electronic platforms with novel capabilities in cardiac physiological mapping and stimulation. Designs for both …
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The role of ATP-sensitive inwardly rectifying potassium channels in the honey bee (Apis mellifera L.)
… ATP-sensitive potassium (KATP) channels in the cardiac regulation of the fruit fly antiviral immune response, but no information is available on their role in the heart-specific regulation of bee immunity. The results of this work demonstrate that KATP channel modulators have an observable …
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Myocardial insulin resistance in experimental uraemia
Cardiac complications are a major cause of death in patients with chronic kidney disease (CKD). Left ventricular hypertrophy (LVH) is a significant contributing factor to uraemic cardiomyopathy and results in significant molecular, cellular and metabolic remodelling. Progression of LVH leads to the …
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The Role of Transforming Growth Factor-Beta In Alcohol-Induced Cardiac Fibrosis
… of 1, 2, 4, 8, 12, and 14 weeks. Changes in cardiac physiology were assessed at respective time points via echocardiography. Additionally, the use of histological techniques, mRNA analysis, apoptosis determination, and immunohistochemistry were employed to determine the functional and …
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Evolutionary Patterns of Avian Tetrodotoxin Resistance
… gains and losses of resistance concentrated in cardiac and peripheral nervous system channels. These patterns resemble those seen in resistant reptiles. Previous work in reptiles also suggested that a vertebrate diet may either directly or indirectly lead to the evolution of TTX resistance in …
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Developing methods for measuring mitochondrial redox status and membrane potential in the isolated perfused heart
… have been identified as a key player in cardiac ischaemia-reperfusion injury serving as both a source and target of damage. The energetic status of mitochondria critically determines the progression of ischaemia-reperfusion injury by dictating the thermodynamic likelihood of reverse …
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Extending Function and Applications of Isolated Cardiopulmonary Systems
… ideas and clinical treatment. Advances in cardiac physiology, surgery, transplantation, pacing, defibrillation, ablation, and pharmacology are derived from this area of research. The work outlined here takes identified issues with experimental preparations, as well as clinical applications, …
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ZFP36L3: a Unique Member of the Tristetraprolin Family of RNA-Binding Tandem Zinc Finger Proteins
… mRNAs that are important for the development or physiology of the placenta. We employed the ribonucleoprotein immunoprecipitation-microarray analysis of mouse placenta lysates to identify possible mRNA targets of L3. Our study identified approximately 400 transcripts that were enriched in …
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Novel Systems Physiology Instrumentation: Addressing Limitations in Heart Failure Reseearch
… failure is one of the most common and costly cardiac diseases in developing and industrialized countries. Despite its important public health implications, no definitive cure exists for heart failure patients. An important reason for this is a wide array of symptoms in heart failure: loss of …
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Performance characteristics of the left ventricle during and following induced extrasystoles
… Many experiments have been devised to study cardiac performance, under different circumstances, as an isolated preparation or as an integrated part of a functioning system. The results derived from these investigations not only proved to be important conceptual tools in making many observed …