Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"Cardiac Conduction"”.
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Extracellular Spaces and Cardiac Conduction
… decades of research and thousands of studies on cardiac electrophysiology, cardiovascular disease remains among the leading causes of death in the United States today. Despite substantially beneficial advances, we have largely shifted cardiovascular disease from an acute to a chronic issue. It is …
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Interplay between Ephaptic and Gap Junctional Coupling in Cardiac Conduction
Sudden cardiac death occurs due to aberrations in the multifactorial process that is cardiac conduction. Conduction velocity (CV) and its modulation by several determinants, like cellular excitability, tissue structure and electrical coupling by gap junctions (GJ), have been extensively studied. …
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Investigating the coordination of cardiac conduction and repolarization in ventricular myocardium
Aberrations in conduction or repolarization are established prerequisites for arrhythmogenesis. The following dissertation investigates how reducing either ephaptic (EpC) or gap junctional (GJ) coupling between cardiomyocytes can modulate cardiac conduction, repolarization, or the relationship …
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Augmentations vs. Restoration: A computational study of the effects of bacterial sodium channels on cardiac conduction.
<p>Cardiac arrhythmias, including ventricular tachycardia, ventricular fibrillation, and atrial fibrillation, are associated with ectopic triggers such as those resulting from afterdepolarizations and structural changes within the cardiac changes. While ectopic triggers can be dealt with via radio …
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Effects of Perfusate Solution Composition on the Relationship between Cardiac Conduction Velocity and Gap Junction Coupling
… has been examined for experiments concerning cardiac electrophysiology. Specifically, multiple labs have found differences in results when comparing cardiac conduction velocity (CV) between healthy mice and mice that were heterozygous null for the gap junction (GJ) forming protein, Connexin …
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Sodium Channel Loss of Function Sensitizes Conduction to Changes in Extracellular Sodium Concentration
Sudden cardiac death is largely attributable to sudden onset ventricular arrhythmias. Alterations in cardiac conduction, particularly the slowing of conduction velocity is one major factor in arrhythmogenesis. By understanding the mechanisms and factors that modulate cardiac conduction velocity, we …
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Sex Differences in Cardiac Electrophysiology
… a male bias and there is more work to be done. Cardiac conduction is a highly synchronized process. Electrical signals are passed cell to cell through two mechanisms, ephaptic coupling and gap junctional coupling. These methods of electrical communication rely on gap junctions, sodium channels …
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Proteomic analysis of the function of DMPK, the myotonic dystrophy protein kinase
… and both DMPK -/- and DMPK +/- mice reiterate cardiac conduction abnormalities characteristic of DM1 patients. However, the in vivo role of DMPK, the identity and nature of its substrate(s) and the biological pathway(s) within which it functions remain to be elucidated. To determine the in vivo …
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Ultrahigh-resolution, deep-penetration spectral-domain optical coherence tomography
… in the infrared. We demonstrate imaging of the cardiac conduction system, which could eventually be used for intraoperative identification of conducting tissue. In addition, we show images of the corneo-scleral angle, which could help properly diagnose primary angle-closure glaucoma. Other …
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Spatially-resolved multiomic profiling of the human heart in adulthood and development
… This thesis contributes to our understanding of cardiac cellular diversity and function by generating two spatially-resolved cell atlases, encompassing the heart in adulthood and development. Chapter 1 summarises cardiac development, cardiac innervation, and the cardiac conduction system, before …
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Dysrhythmias in Laypersons during Centrifuge-Simulated Suborbital Spaceflight
Introduction: There are limited data on cardiac dysrhythmias in laypersons during hypergravity exposure. We report layperson electrocardiograph (ECG) findings and tolerance of dysrhythmias during centrifuge-simulated suborbital spaceflight. Methods: Volunteers participated in varied-length …
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Adaptive Output Feedback Stabilization of Nonlinear Systems
… method is demonstrated by an application to a cardiac conduction system modelled by two coupled driven oscillators. An output feedback design technique is developed to achieve semi-global practical stabilization for a class of non-minimum phase nonlinear systems, subject to param- eter …
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Noninvasive Multi-Modality Studies of Cardiac Electrophysiology, Mechanics, and Anatomical Substrate in Healthy Adults, Arrhythmogenic Cardiomyopathy, and Heart Failure
… electrical function of heart muscle cells or the cardiac conduction system. Electrocardiographic Imaging (ECGI) is a noninvasive modality for imaging cardiac electrophysiology. By combining recordings of the voltage distribution on the torso surface with anatomical images of the heart-torso …
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Arrhythmogenic mechanisms of acute cardiac infection
… cause of death world-wide, with 42% of sudden cardiac death in young adults caused by myocarditis. Viruses represent the main cause of myocarditis, with adenovirus being a leading pathogen. However, it is not understood how adenoviruses cause sudden cardiac arrest. Myocarditis is defined by two …
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Global analysis of mRNA decay rates and RNA-binding specificity reveals novel roles for CUGBP1 and PARN deadenylase in muscle cells
… Dystrophy (DM1) is characterized by myotonia, cardiac conduction defects, muscle wasting, and insulin resistance. In patient muscle cells expression and function of the RNA-binding proteins CUGBP1 and MBNL1 are disrupted, resulting in altered mRNA metabolism at the levels of splicing and …
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Lamin A and lamin C are differentially dysfunctional in autosomal dominant Emery-Dreifuss muscular dystrophy
… wasting and cardiomyopathy associated with cardiac conduction defect. The autosomal dominant form is caused by mutations in the LMNA gene which gives rise to lamin A and lamin C proteins by alternative splicing. These A-type lamins, together with B-type lamins, form the nuclear lamina, a …
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RUOLO DELLA STIMOLAZIONE VAGALE SULLA PROLIFERAZIONE DEI FIBROBLASTI CARDIACI IN VIVO IN MODELLO ANIMALE DI FIBRILLAZIONE ATRIALE.
Introduction: Cardiac fibrosis is a pathological response that causes abnormalities in cardiac conduction and mechanical function, thereby contributing to the pathophysiology of a variety of cardiac conditions, including hypertrophy, failure, and arrhythmias. Atrial fibrillation (AF) is the most …
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Parametric heart modelling and in silico closed-loop validation of implantable devices
Medical Cyber-Physical systems (MCPS), such as cardiac pacemakers and implantable cardioverter defibrillators (ICDs), are life-critical and context-aware. These devices have been increasingly used to provide continuous health-care for patients. The complicated heterogeneous physical dynamics of …
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Role genu Nkx2.5 v morfogenezi a elektrofyziologii srdce u myši
Role genu Nkx2.5 v morfogenezi a elektrofyziologii srdce u myši Praha 2016 Bc. Peter Hámor ABSTRAKT Cieľom tejto práce je skúmanie vplyvu dávkovania génu Nkx2.5 na elektrofyziológiu srdca myší v prenatálnom období vývoja. Hlavnou úlohou je hľadanie rozdielov vo vedení elektrického vzruchu v srdci …
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The Relationship between Ephaptic Coupling and Excitability in Ventricular Myocardium
… sodium channels to trigger an action potential. Conduction in cardiomyocytes is dependent on the robustness and speed of action potential propagating through tissue. Both are equally important for normal heart function and claim to be linear correlated (i.e if conduction decreases, excitability …