Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"Cardiac Cells"”.
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Flavonoid protection of cardiac cells against ischemia-reperfusion injury
… injury occurs following the majority of cardiac events including myocardial stenosis and heart surgeries. As reactive oxygen species are one of the major contributors to ischemia-reperfusion injury, strategies to prevent their effects may be directed towards enhancing the antioxidant …
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Quantifying Structural and Functional Changes in Cardiac Cells in an In Vitro Model of Diabetic Cardiomyopathy
… structural and biochemical alterations at the cardiac cell level. Early stage cell alterations include hypertrophy, calcium mishandling, cell apoptosis, excessive ROS production, and increased collagen production by fibroblasts. Eventually, major structural and functional changes can appear in …
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Expression and Regulation of Osteopontin in the Diabetic Heart
<p>Diabetes leads to several alterations in cardiac structure, one of which is fibrosis of the ventricular myocardium. Myocardial fibrosis is a common underlying factor in most cardiac pathologies. Osteopontin (OPN) is a small phospho-protein that has been implicated in fibrotic tissue remodeling. …
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An in Vitro Study of Cellular Cardiomyoplasty: Structural and Functional Interactions of Non-cardiomyocytes and Cardiomyocytes
… structural and functional interactions between cardiac and non-cardiac cells is essential to better address the sequelae of cardiac disease and improve the potential cellular implantation therapies. First, an in vitro model was established to investigate the probability that electromechanical …
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The role of Nox2 containing NADPH oxidase in hypertensive heart disease
… reported to be involved in the development of cardiac hypertrophy and fibrosis. However the relevant cellular source(s) involved in the above effects remains unclear. The aim of this thesis was to investigate the critical cell source of the Nox2 in a model of angiotensin II (AngII) induced left …
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Trasduzione del segnale e poliamine nell'apoptosi di cellule cardiache
… a potential therapeutic target. Apoptosis of cardiac cells can be induced experimentally by several stimuli including hypoxia, serum withdrawal or combination of both. Several lines of research suggest that neurohormonal mechanisms play a central role in the progression of heart failure. In …
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A study of phase resetting, mutual entrainment, and modified ventricular parasystole using a model of coupled heart cells
Several aspects of cardiac electrophysiology including phase-resetting and entrainment are investigated through the dynamic interactions of coupled mathematical models of cardiac cells. Unlike previous studies of cell interaction which have used simplified models of a general cardiac cell or …
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The effects of aging on cardiac mechanics
… the hypothesis that the mechanical properties of cardiac myocytes significantly change with aging thereby contributing to the LV diastolic dysfunction. Cellular mechanical properties were determined by indenting cells with an atomic force microscope (AFM). The indentation results were interpreted …
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Nonlinear Dynamics, Synchronisation and Chaos in Coupled FHN Cardiac and Neural Cells
… aspects needed to gain access to both cardiac and neural systems for a researcher trained in a mathematically based discipline. By using techniques from nonlinear dynamical systems theory I show a number of results that have implications for both neural and cardiac cells. Examining a …
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The effects of aging and transformation on the DNA, RNA, protein, and hydroxyproline content of fibroblasts (WI 38) in culture
… as to how the passage of time affects cells, organs, and organisms. Aging is a very complex and incompletely understood phenomenon. This is reflected by the number of theories attributing aging to a variety of causative factors such as: (1) the somatic mutations occurring spontaneously …
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Designing Polymer Hydrogels for Extrusion-Based Additive Manufacturing
… development of a 3D-printable bioink based on cardiac decellularized extracellular matrix (cdECM). While Chapter 2 and Chapter 3 deal with molecular-level changes to wholly synthetic polymer systems, Chapter 4 deals with biopolymers derived from porcine cardiac cells that are combined with …
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Cells of the Developing Human Heart and Great Vessels
… of its cellular makeup, we can uncover how these cells converge to define cardiac identity and function and how perturbation to cellular identities can lead to diseases. This dissertation focuses on generating a high-resolution atlas of the first and second-trimester human heart and great vessels …
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The Voltage Gated Sodium Channel β1/β1B subunits: Emerging Therapeutic Targets in the Heart
… β subunits. While much of the field of cardiac electrophysiology and pathology has focused on treating and preventing cardiac arrhythmias by targeting the α subunit, there is also evidence that targeting the β subunits, particularly SCN1B, the gene that encodes β1 and an alternatively …
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Cardiac tissue engineering : bioreactor cultivation parameters
… of a model tissue engineering system influenced cardiac tissue morphogenesis. The central hypothesis was that using a tissue engineering system consisting of isolated cardiac cells, polymer scaffolds, and tissue culture bioreactors, we could engineer cardiac muscle mimicking native tissue in …
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Alimenti Funzionali e Componenti Nutraceutici come Biomodulatori
… plays a major role in the pathophysiology of cardiac disorders has led to extensive investigations of the protective effects of exogenous antioxidants, but results are controversial. A promising strategy for protecting cardiac cells against oxidative damage may be through the induction of …
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Modulation of mitogenic signaling and growth by sympathetic adrenergic regulation
… United States. Both diseases are associated with cardiac remodeling, including cellular growth and fibrosis. Central to the progression of heart disease and diabetes are the adrenergic receptors (ARs) and insulin receptors (IR), respectively. Classically considered to elicit separate, and even …
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Growth and chemical functionalization of SiC nanowires for biomedical applications in cardiology and oncology
… these diseases is still long, and cancer and cardiac diseases remain a serious socio-economic problem for our society. For this reason, this PhD research focuses on these two main topics; called in the thesis the oncology project and the cardiology project. Both projects were devoted to the …
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Cancer metastasis and elasticity of microenvironment
… the parent tumor. During metastasis, malignant cells detach from the parent tumor, and spread through circulatory system to invade new tissues. Due to the intrinsic difficulties of predicting and monitoring in vivo metastasis, the physical-chemical mechanisms and parameters within the cellular …
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2D and 3D patterning of molecules and cells
… understand the need for patterning molecules and cells for uses in medicine and engineering. Our goal is to be able to understand how cells and biological systems develop and how we can use design to harness cellular function. Two approaches are taken to pattern multiple cell types, and build 2D …
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THE EFFECTS OF MYOCARDIAL INFARCTION ON NEUROINFLAMMATION: FOCUS ON THE ROLE OF EXTRACELLULAR VESICLES
… a collection of diseases, most importantly cardiac ischemia. Complications following cardiac ischemia represent a significant risk factor that threatens the patient’s quality of life in both short and long terms and affect many body organs, such as the brain. Many research studies …
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