Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"Carcinoma, Squamous Cell"”.
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HPV-Positive and HPV-Negative Vulvar Squamous Cell Carcinoma Are Biologically, but Not Clinically, Distinct
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Periocular malignancy.
… the eyelids in order of frequency are: basal cell carcinoma (90%), squamous cell carcinoma (5-8%), sebaceous gland carcinoma (2-3%) and melanoma (1%). The eyelids represent a high risk area for recurrence and are also functionally integral to the protection of the eye. Hence, surgical excision …
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Studies of the Molecular Features of Brd4-Nut and P300 That Contribute to Condensate Formation and Transcriptional Regulation
… gene expression and forms condensates in Nut Carcinoma (NC). It has not been clear how these condensates form and whether they modulate gene expression. Here, I dissected the molecular features of Brd4-Nut and a histone acetyltransferase (HAT), p300, and analyzed their contribution to …
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Oncogene-Induced Signaling Heterogeneity in Lung Cancer
… the signaling heterogeneity within tumor cells with identical genetic changes remain poorly understood. Hence, I focus on TP53, KRas and C-Myc as they are among the most frequently occurring oncogenic alterations in lung adenocarcinoma. The downstream signaling changes of these genes may …
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Factors Promoting Human Papillomavirus Mediated Cervical Carcinogenesis
<p>High-risk human papillomavirus (HPV) is the causative agent of cervical cancer. Integration of the HPV genome into the host genome is a key event in cervical carcinogenesis, with oxidative stress (OS) likely playing a major role in promoting DNA damage, and subsequently, integration. In our …
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Investigating the role of growth hormone receptor in oesophageal squamous-cell carcinoma.
Squamous-cell carcinoma of the oesophagus is a formidable disease which poses a significant health risk in developing countries where incidence is high and survival is low. Investigating the poorly understood mechanisms involved in oesophageal tumourigenesis may provide a platform to develop …
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Molecular Classification of Basal Cell Carcinoma of Skin by Gene Expression Profiling
Non-melanoma skin cancers (NMSC) including basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are more common kinds of skin cancer. Although these tumors share common pathological and clinical features, their similarity and heterogeneity at molecular levels are not fully elaborated yet. …
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Radiosensitization of Head & Neck Carcinoma Cells by Linifanib, A Receptor Tyrosine Kinase Inhibitor
… and metastasis. Over 90% of head and neck squamous cell carcinomas (HNSCC) express angiogenic factors such as vascular endothelial growth factor (VEGF). Since radiotherapy is one of the most commonly used treatments for HNSCC, it is imperative to identify the interactions between …
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Aspects of skin cancer diagnosis in clinical practice
… The three most common skin cancers are basal cell carcinoma (BCC), squamous cell carcinoma (SCC) and malignant melanoma (MM). A correct diagnosis is crucial for an efficient and tailored treatment for the skin cancer patient. The purpose of this thesis was to evaluate different aspects of the …
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Genetic analyses, protein expression, type and function with clinical and immunological correlates in human papillomavirus associated head and neck neoplasia
In head and neck squamous cell carcinoma (HNSCC), the evidence that human papillomavirus (HPV) is associated with a subgroup of tumours has increased over the last thirty years. Prospective randomised controlled clinical trials have now established that detection of HPV in oropharyngeal tumours …