Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Carcinoma, Renal Cell"”.
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Using Tissue Morphology to Infer Intra-Tumor Variation in Molecular State and Response
… approaches are applied to two cancer types clear-cell renal cell carcinoma (ccRCC) and colorectal cancer (CRC). In ccRCC, we aim to understand the extent to which intra-tumor variation in key driver genes, BAP1, PBRM1, and SETD2, can be inferred purely from the analysis of histopathology slides. …
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Investigating the Role of Hippo/Warts Signaling in Sarcomatoid Renal Cell Carcinoma
Renal cell carcinomas (RCCs) are the most common kidney malignancy and one of the most common cancers overall. Sarcomatoid RCC (sRCC) is a particularly aggressive subtype of RCC which displays a high rate of metastasis and poor prognosis, contributing to a disproportionately high clinical burden. …
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Chemoprevention in Kidney Cancer
Background: This thesis is a composition of three studies that explore the role of statins in kidney cancer. Furthermore, I evaluate the potential for different interpretations from the same data depending on the method of classifying medication use. Methods: The first study was a population-based …
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Small Molecule Inhibitors of MAPK and PI3K Pathways Enhance MDA-7 Lethality in Renal Cell Carcinoma
Renal cell carcinoma accounted for an estimated 57,760 new cases and estimated 12,980 deaths in the United States in 2009. Current treatment options for systemic renal cell carcinoma yield markedly low response percentages; however, recent cytokine therapy experiments have produced promising …
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Identification and characterisation of HNF1B as a pro-tumorigenic lineage factor in clear cell renal cell carcinoma
Clear cell renal cell carcinoma (ccRCC) is the most common subtype of renal cancer. ccRCCs exhibit considerable genetic intratumour heterogeneity, and current therapies lack long-term efficacy due to drug resistance. Novel therapeutic targets are thus required to combat this disease. The most …