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Showing 1 to 5 of 5 for “"Carcinoma, Pancreatic Ductal"”.
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Inhibition of Discoidin Domain Receptor 1 Reduces Collagen-Mediated Tumorigenicity in Pancreatic Ductal Adenocarcinoma
… fibrillar collagens is a principal component of pancreatic ductal adenocarcinoma (PDA). The ECM provides structural support for the tumor and facilitates tumor cell survival and chemoresistance by activating cell surface receptors on tumor cells. Fibrillar collagens bind the collagen-specific …
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Targeting Cyclin Dependent Kinases 4/6 Activity in Pancreatic Ductal Adenocarcinoma
Pages vi-xiii are incorrectly numbered as pages v-xii.
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Loss of TBK1 Kinase Function Improves Disease Outcome in Pancreatic Cancer and Metabolic Syndrome
… Here I've identified novel functions for TBK1 in pancreatic ductal adenocarcinoma (PDA) and in metabolic syndrome that promote disease progression. Activating mutations in KRAS are present in 90% of human PDA cases; yet direct pharmacological inhibition of K-RAS remains a challenge, indicating a …
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Survivin: Regulation by YY1 and Role in Pancreatic Cancer Combination Therapy
… design logical new approaches to cancer therapy. Pancreatic cancer is one of the most deadly forms of cancer known, and survivin expression has been observed to be an important factor in pancreatic cancer aggressiveness or resistance to therapy. Therefore survivin downregulation may represent an …
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Curcumin: A Multi-dimensional Approach to Pancreatic Cancer Targeting Cell Death and Exosomes
<p>Pancreatic cancer is currently one of the most difficult diseases to treat due to difficulty of detection and the aggressive nature of the disease. In addition, pancreatic cancer has the highest mortality rates compared to other cancer types. These mortality rates are attributable in part to …