Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 25 for “"Carcinoma, Non-Small-Cell Lung"”.
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Optimization of BRAF V600 Assay as A 2-Step Real-time PCR Protocol
… abnormally active, which disrupts regulation of cell growth and division. Mutations in this gene have been found in cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, papillary thyroid carcinoma, non-small-cell lung carcinoma, gastric cancer, and even prostate cancer. …
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Peptide Targeted Drug Delivery to Non-Small Cell Lung Cancer
Non-small cell lung cancer (NSCLC) is a notoriously deadly disease. The integrin αᵥβ₆ is emerging as a viable target for NSCLC; it is expressed in more than half of NSCLC patient tumor samples and only rarely expressed in normal tissue. Importantly, αᵥβ₆ is turned on early in the disease …
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Beta-Lapachone Nanotherapeutics for Lung Cancer Therapy
A rising trend in lung cancer chemotherapy involves the development of agents that exploit molecular targets overexpressed in tumors, with hopes of increasing specificity, and in turn, efficacy. β-Lapachone (β-lap) is a novel anticancer drug whose mechanism of action relies on its bioactivation by …
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Identifying Context-Specific Synthetic Lethal miRNA Inhibition in Non-Small Cell Lung Cancer
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related fatalities in the US. This is due in part to a lack of highly effective therapies for advanced cases, and this is of special concern as most NSCLC cases are not diagnosed until they are in an advanced, later stage. Recent …
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Preclinical Studies of Telomerase Inhibitor Imetelstat in Non-small Cell Lung Cancer
… all cancers but is not expressed in most somatic cells making it an attractive target for cancer therapy. Telomerase has two essential components, a reverse transcriptase (hTERT) and an RNA template (hTR or hTERC). The RNA template is used by the reverse transcriptase to add the TTAGGG hexameric …
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Metabolic Diversity in Human Non-Small Cell Lung Cancer Cells
Cancer cells display oncogene-driven rewiring of metabolism to produce energy and macromolecules for growth. Inhibition of growth-promoting metabolic pathways may prove to be a useful therapeutic strategy in cancer. However, neither the full breadth of cancer cell metabolic diversity, nor the …
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MiR-10a Regulation of Drug Response and Cancer Stem Cell Populations in Non-Small Cell Lung Carcinomas
… (PI3Ks) are enzymes involved in diverse cellular functions including cell growth, proliferation, differentiation, motility, survival and apoptosis. Many of these functions relate to class I PI3Ks, heterodimers composed of regulatory and catalytic subunits that convert extracellular cues …
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Heterogeneity in Human NSCLC Tumor Glucose Metabolism: On the Origins and Role of Pyruvate Metabolism
Pages 9-96 are misnumbered as pages 10-97.
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Exploiting Multi-Cell Type Cultures to Elucidate Tumor Cell Features That Impact Macrophage Phenotype
Lung cancer is expected to kill ~150,000 people this year, encompassing 25% of all cancer related deaths making lung cancer the leading cause of cancer-related mortality in men and women. Lung cancer is divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) which …
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Regulation of Clathrin Mediated Endocytosis and Its Role in Cancer Progression
… is a multistep process requiring cancer cell signaling, invasion, migration, survival, and proliferation. These processes require dynamic modulation of cell surface proteins by endocytosis. Given this functional connection, it has been suggested that endocytosis is dysregulated in cancer. …
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Discovery and Development of Predictive Biomarkers for the Personalization of Pemetrexed Therapy in Non-Small Cell Lung Cancer
Lung cancer is a major health problem, and is the leading cause of cancer-related deaths. This research proposal was designed to personalize and improve overall response rates to the FDA-approved chemotherapeutic pemetrexed. To do so, clinically-applicable response phenotypes of a large panel of …
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Part I: Steroid Receptor CO-Activator 3 (SRC-3) Expression in Lung Cancer and its Role in Regulating Cancer Cell Survival and Proliferation; Part II: Development of Phosphospecific Peptoid Ligand
… RECEPTOR CO-ACTIVATOR 3 (SRC-3) EXPRESSION IN LUNG CANCER AND ITS ROLE IN REGULATING CANCER CELL SURVIVAL AND PROLIFERATION Steroid receptor coactivator-3 (SRC-3) is a histone acetyltransferase and nuclear hormone receptor (NHR) coactivator, located on 20q12, which is amplified in several …
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Exploration of Nuclear Receptor Activity and siRNA-Derived Phenotypes as Therapeutics in Non-Small Cell Lung Cancer
… receptors are master regulators of diverse cellular functions implicated in tumor pathogenesis and as oncogenic drivers of many human cancers. To better understand what role these important receptors might be playing in lung cancer, three interconnected studies were initiated to assess …
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Characterization of mTOR Inhibition and Autophagy Inhibition in Non-Small Cell Lung Cancer
Lung cancer continues to be the leading cause of cancer related death in both men and women. Pre-clinical studies of targeted therapies are needed in order to improve upon the chemotherapeutics that are currently in use. The ability to identify subsets of patient tumors which will respond to a …
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Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism
… of immortalized human bronchial epithelial cells. TMPRSS11B is upregulated in human lung squamous cell cancers and high expression is associated with poor survival of non-small cell lung cancer patients. TMPRSS11B depletion in human lung squamous cell cancer reduced transformation and tumor …
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Mechanisms of Sensitization to Chemotherapy in Non-Small Cell Lung Cancer
Lung cancer is the leading cause of cancer-related deaths world-wide for men and women, due in part to late detection of disease and inherent resistance to treatment. This body of work focuses on resistance to treatment, specifically chemotherapy and understanding ways to sensitize non-small cell …
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The Role of RUVBL1/RUVBL2 and Their Potential as Therapeutic Targets in Non-Small Cell Lung Cancer
… of death today in Americans. Among cancers, lung cancer is the deadliest, killing as many individuals as next 3 most lethal cancer types combined. Approximately 80% of lung cancers are a type known as non-small cell lung cancer (NSCLC), and despite numerous advances in the treatment of NSCLC, …
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Therapeutic Targeting of Protocadherin 7 in Lung Adenocarcinoma
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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SMARCA4/BRG1-Inactivating Mutations as Potential Predictive Markers for Aurora Kinase A-Targeted Therapy in NSCLCs
… ALK lesions create one of the largest subsets of Non-Small Cell Lung Cancers (NSCLCs). Since these mutations have been identified as bona fide tumor suppressors, efforts have focused on understanding the pathology of cancer caused by SMARCA4/BRG1 aberrations. However, no therapeutic agent has been …
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An In Vivo Functional Genomics Screen Identifies New Regulators of Tumorigenesis in Non-Small Cell Lung Cancer
Cancer cells are characterized by the aberrant regulation of signaling pathways that govern responses to growth stimuli, resulting in dysregulated cellular proliferation. The accumulated genomic alterations that cause this malignant growth phenotype can also result in acquired vulnerabilities in …
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