Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Carcinoma, Hepatocellular"”.
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The Efficacy of Immunotherapy in Preventing Liver Cancer and the Role of Metabolic Zonation in Its Development
… characteristics that are relevant to human hepatocellular carcinoma (HCC). There is a diverse array of mouse HCC models available, falling into three major categories: transplantation-based models, chemically-induced models, and genetically-induced models. Within these categories, models …
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Quality of Life Is Associated with Survival in Patients with Cirrhosis and Hepatocellular Carcinoma
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Effect of Fragmentation of Cancer Care on Treatment Use and Survival in Hepatocellular Carcinoma
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Glucose-6-Phosphatase in Metabolic Disease and Cancer
… includes the formation of liver adenomas and carcinomas without obvious signs of liver injury or cirrhosis. Here we show that the oncogenic transcription factor c-Myc potentiates metabolic rewiring and drives lactic acidosis and hyperuricemia in a mouse model of GSD1a. Using metabolic …
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DESIGNING ANTI-PDL1 ANTIBODY CONJUGATED POLYMERIC COACERVATES AS A NOVEL “NANO-IMMUNOTHERAPY” AGAINST HEPATOCELLULAR CARCINOMA
Hepatocellular Carcinoma (HCC) accounts for a majority of primary liver cancer cases and is among the deadliest cancers in the world. With a shift in major risk factors from chronic viral hepatitis infections to that of metabolic diseases causing HCC, the number of HCC-related cases and deaths is …
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THE ROLE OF TETRASPANIN-8 IN ASTROCYTE ELEVATED GENE-1 MEDIATED PROGRESSION OF HEPATOCELLULAR CARCINOMA
Hepatocellular carcinoma (HCC) is a devastating form of liver cancer that accounts for 80% of liver cancers. HCC has a poor prognosis with five-year survival of less than 12% in the United States. We in previous studies have identified Astrocyte Elevated Gene-1 (AEG-1) as an aberrantly …
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TRANSFORMATION OF PRIMARY HUMAN HEPATOCYTES IN HEPATOCELLULAR CARCINOMA
Hepatocellular carcinoma (HCC) is the most common primary liver cancer. Currently, there is limited knowledge of neoplastic transformation of hepatocytes in HCC. In clinical practice, the high rate of HCC local recurrence suggests the presence of different hepatocyte populations within the liver …
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LINKING CHROMATIN REMODELING TO MITOCHONDRIAL DYSFUNCTION: A ROLE FOR THE SMARCA5-MYC-TFAM AXIS IN HEPATOCELLULAR CARCINOMA
Hepatocellular carcinoma (HCC) is an aggressive primary liver malignancy characterized by poor prognosis, limited therapeutic options, and frequent resistance to conventional treatments. Metabolic reprogramming, particularly involving mitochondria, is a hallmark of cancer and represents a potential …
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Analysis of Exome Sequencing in Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is the type of cancer difficult to classify and analyze despite the high occurrence, because it displays a high level of tumor heterogeneity with complex etiology. For unbiased analysis of HCC with diverse tumorigenic backgrounds, a genomewide study that does not …
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Investigating the Heterogeneity of Tumor Associated Macrophages in Human Hepatocellular Carcinoma
Hepatocellular carcinoma (HCC) is a liver cancer and is one of the leading causes of cancer death worldwide. Despite significant efforts in treating HCC, such as with the use of novel immune checkpoint inhibitors, the overall response rate remains low. This may be partly attributed to the lack of a …