Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"Carcinoembryonic antigen (CEA)"”.
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Kasos adenokarcinomos diagnostinių ir prognostinių biožymenų paieška /
… analysed via high-definition mass spectrometry. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) was discovered as a possible promising pancreatic cancer biomarker. The predominance of CEACAM6 to pancreatic cancer was validated using antibodies in tissue samples. CEACAM6, …
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Antibody engineering for tumor immunotherapy
… to improving antibodies as cancer therapeutics. Carcinoembryonic antigen (CEA) has long been identified as a tumor-associated antigen. CEA is also quite stable, with a cell-surface shedding half-life of approximately 7 days. Directed evolution methodology has been utilized to design an antibody …
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Synergistic anti-tumor immune response to combination immunotherapy consisting of anti-tumor antibodies, extended half-life Interleukin-2, and other immunomodulatory agents
… we find that a combination of an anti-tumor antigen antibody and an untargeted IL-2 fusion protein with delayed systemic clearance induces significant tumor control in aggressive isogenic tumor models via a concerted innate and adaptive response. We find that this therapy induces the …
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Functional DNA Aptamers as Biotherapeutic Molecules
… the Tumour Necrosis Factor alpha (TNFα) and Carcinoembryonic Antigen (CEA), and block their biological functions. As well, I investigated the use of CEA and MUC1 binding aptamers as targeting agents to guide and detect the delivery of contrast agent-loaded liposomes in tumour-bearing mice …
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Engineering antibodies for improved targeting of solid tumors
… ability to specifically bind tumor-expressed antigens. Unfortunately, attempts to treat solid tumors with these drugs are often limited by an inability of the antibodies to fully penetrate the tumor tissue, leaving large regions of untargeted and viable cells. The goal of this thesis is to …
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The pathogenesis of idiopathic pulmonary fibrosis
… into the respiratory epithelium with release of carcinoembryonic antigen (CEA) in peripheral circulation as evidenced by a significant correlation of raised CEA level and lung function impairment in IPF.These findings provide clinical and molecular evidence of novel mechanisms of pathogenesis of …
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Nuclear Factor Kappa B Pathway and human cancer therapeutics
… system to improve the promoter activity of carcinoembryonic antigen (CEA) and human telomerase reverse transcriptase (hTERT) for GDEPT. In this system, the basal CEA promoter sequences were placed downstream of the 4 or 8 NF-κB DNA binding sites linked in tandem (κB4 or κB8). The system was …
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Synthesis and Characterization of Multi-Functional Nanoparticles for Therapeutic and Biosensing Applications
… and quantify two different cancer markers — carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) from diluted whole blood or undiluted serum, on a paper-based microfluidic platform. These particles were covalently conjugated with anti-CEA and anti-CA 19-9 antibodies and …
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Development of label-free colorimetric plasmonic sensor for biomedical applications
… of lower concentration of cancer biomarker, carcinoembryonic antigen (CEA) with higher sensitivity, which is discussed in chapter 6. The summary of the thesis with future outlook of the nanoplasmonic biosensor is discussed in chapter 7.
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Molecular analysis and application of tissue microarray technology to the histopathological and immunohistochemical analysis of cervical adenocarcinoma
… sections were immunostained with 8 antibodies, carcinoembryonic antigen (CEA), Cytokeratin7 (CK7), Cytokeratin20 (CK20), estrogen receptor (ER), progesterone receptor (PgR), phosphatase and tensin homolog deleted on chromosome ten (PTEN), MIB-1 proliferation marker, and p53 suppressor gene …
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ΜΕΛΕΤΗ ΤΗΣ Β_2 ΜΙΚΡΟΣΦΑΙΡΙΝΗΣ (Β_2Μ) ΤΟΥ ΟΡΟΥ ΣΕ ΠΑΘΗΣΕΙΣ ΤΟΥ ΗΠΑΤΟΣ: ΣΥΣΧΕΤΙΣΗ ΜΕ ΤΗΝ α_1 ΕΜΒΡΥΙΚΗ ΠΡΩΤΕΙΝΗ (α_1ΕΠ) ΚΑΙ ΤΟ ΚΑΡΚΙΝΟΕΜΒΡΥΙΚΟ ΑΝΤΙΓΟΝΟ (CEA)
Η Β2 ΜΙΚΡΟΣΦΑΙΡΙΝΗ ΜΕΤΡΗΘΗΚΕ ΣΤΟΝ ΟΡΟ 78 ΑΣΘΕΝΩΝ ΜΕ ΟΞΕΙΑ ΗΠΑΤΙΤΙΔΑ, ΧΡΟΝΙΕΣ ΗΠΑΤΟΠΑΘΕΙΕΣ ΚΑΙ ΗΠΑΤΟΚΥΤΤΑΡΙΚΟ ΚΑΡΚΙΝΟ (ΗΚΚ). ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΕ ΡΑΔΙΟΑΝΟΣΟΜΕΤΡΙΚΗ ΜΕΘΟΔΟΣ ΚΑΙ ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΣΥΓΚΡΙΘΗΚΑΝ ΜΕ ΑΥΤΑ 15 ΥΓΙΩΝ ΜΑΡΤΥΡΩΝ (ΟΕ). ΣΤΟΥΣ ΑΣΘΕΝΕΙΣ ΜΕ ΟΞΕΙΑ ΙΟΓΕΝΗ ΗΠΑΤΙΤΙΔΑ Η Β2Μ ΕΙΧΕ ΜΕΣΗ ΤΙΜΗ 7,75 …
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Η ΣΗΜΑΣΙΑ ΤΟΥ ΠΡΟΣΔΙΟΡΙΣΜΟΥ ΩΡΙΣΜΕΝΩΝ ΒΙΟΛΟΓΙΚΩΝ ΠΑΡΑΜΕΤΡΩΝ ΣΤΗ ΜΕΛΕΤΗ ΤΟΥ ΚΑΡΚΙΝΟΥ
… transpeptidase, 5'-nucleotidase, and carcinoembryonic antigen were determined in 256 cancer patients in order to evaluate their significance in diagnosis and patient monitoring. Our results indicate that in most cases there is a marked increase of phosphohexosoisomerase. The levels of …
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Ο ΒΑΘΜΟΣ ΓΛΥΚΙΩΣΗΣ ΤΗΣ Α1-ΟΞΙΝΗΣ ΓΛΥΚΟΠΡΩΤΕΙΝΗΣ ΤΟΥ ΟΡΡΟΥ ΩΣ ΔΕΙΚΤΗΣ ΣΕ ΚΑΚΟΗΘΗΝΕΟΠΛΑΣΙΑ
ΣΤΗΝ ΠΑΡΟΥΣΑ ΔΙΑΤΡΙΒΗ ΜΕΛΕΤΗΘΗΚΕ Ο ΒΑΘΜΟΣ ΓΛΥΚΙΩΣΗΣ ΤΟΥ ΜΟΡΙΟΥ ΤΗΣ Α1- ΟΞΙΝΗΣ ΓΛΥΚΟΠΡΩΤΕΙΝΗΣ (Α1AGP) ΜΕ ΤΗΝ ΜΕΘΟΔΟ ΤΗΣ ΑΝΟΣΟΗΛΕΚΤΡΟΦΟΡΗΣΗΣ ΣΥΓΓΕΝΕΙΑΣ ΔΥΟ ΔΙΑΣΤΑΣΕΩΝ ΜΕ CONCANAVALIN A ΣΤΗΝ ΠΡΩΤΗ ΔΙΑΣΤΑΣΗ. ΜΕΛΕΤΗΘΗΚΕ ΤΟ ΑΝΟΣΟΗΛΕΚΤΡΟΦΟΡΗΤΙΚΟ ΠΡΟΤΥΠΟ ΤΗΣ Α1AGP (PATTERN) ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΝΕΟΠΛΑΣΜΑΤΑ …