Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Carcinoembryonic antigen"”.
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Pre-operative determination of Carcinoembryonic Antigen (p-CEA) as an independent prognostic factor of Disease Free Survival (DFS) in patients treated for colorectal carcinoma
… carcinoma colorettale, se la determinazione dell’antigene carcinoembrionario (p-CEA) possa avere una valenza prognostica e costituire un fattore di rischio indipendente in relazione al disease free survival. BACKGROUND: Il p-CEA sembra essere correlato sia alla stadiazione della neoplasia …
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Kasos adenokarcinomos diagnostinių ir prognostinių biožymenų paieška /
… analysed via high-definition mass spectrometry. Carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) was discovered as a possible promising pancreatic cancer biomarker. The predominance of CEACAM6 to pancreatic cancer was validated using antibodies in tissue samples. CEACAM6, …
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Η ΣΗΜΑΣΙΑ ΤΟΥ ΠΡΟΣΔΙΟΡΙΣΜΟΥ ΩΡΙΣΜΕΝΩΝ ΒΙΟΛΟΓΙΚΩΝ ΠΑΡΑΜΕΤΡΩΝ ΣΤΗ ΜΕΛΕΤΗ ΤΟΥ ΚΑΡΚΙΝΟΥ
… transpeptidase, 5'-nucleotidase, and carcinoembryonic antigen were determined in 256 cancer patients in order to evaluate their significance in diagnosis and patient monitoring. Our results indicate that in most cases there is a marked increase of phosphohexosoisomerase. The levels of …
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Prognostické a prediktivní markery v léčbě karcinomu pankreatu
… ≥3, systemic inflammatory response index <2.3, carcinoembryonic antigen <2.5, neutrophil-to-lymphocyte ratio <5, Memorial Sloane Kettering score...
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The Role of the ITAM-containing CEACAM3 Receptor in the Neutrophil Response to Infection by Neisseria gonorrhoeae
… which interact with some members of the human carcinoembryonic antigen-related cellular adhesion molecule (CEACAM) family. One of these CEACAMs, CEACAM3 (CD66d), is unique in its restriction to neutrophils and its expression of a cytoplasmic immunoreceptor tyrosine-based activation motif (ITAM; …
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Development of nanoplasmonic devices for biosensing applications
… for the detection of the cancer biomarker carcinoembryonic antigen. The optical properties of this device are studied in detail and its distinct spectral properties simultaneously reduce instrumentation requirements and improve the limit of detection to a suitable level for cancer biomarker …
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Antibody engineering for tumor immunotherapy
… to improving antibodies as cancer therapeutics. Carcinoembryonic antigen (CEA) has long been identified as a tumor-associated antigen. CEA is also quite stable, with a cell-surface shedding half-life of approximately 7 days. Directed evolution methodology has been utilized to design an antibody …
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Engineering targeted proteins for intracellular delivery of biotherapeutics
… targeted towards the canonical cancer-specific antigens: epidermal growth factor receptor and carcinoembryonic antigen. Using quantitative internalization flow cytometry matched with controlled exposure cytotoxicity, the number of internalized gelonin immunotoxins required to induce apoptosis in …
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Tumor Response TCF-4/β-Catenin Regulatory Elements for Enhancing Cancer Gene Therapies
… enhancer element in combination with a c-fos or carcinoembryonic antigen promoter was tested for its ability to act as a tumor specific regulator of gene expression in a panel of human tumor and normal cell lines. Luciferase reporter assays indicated enhanced activity of the Tcf-4/β-catenin …
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Synergistic anti-tumor immune response to combination immunotherapy consisting of anti-tumor antibodies, extended half-life Interleukin-2, and other immunomodulatory agents
… we find that a combination of an anti-tumor antigen antibody and an untargeted IL-2 fusion protein with delayed systemic clearance induces significant tumor control in aggressive isogenic tumor models via a concerted innate and adaptive response. We find that this therapy induces the …
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Fibronectin domain engineering
… Binders were engineered to tumor targets carcinoembryonic antigen, CD276, and epidermal growth factor receptor as well as biotechnology targets human serum albumin and goat, mouse, and rabbit immunoglobulin G. Binders have demonstrated utility in affinity purification, laboratory …
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Functional DNA Aptamers as Biotherapeutic Molecules
… the Tumour Necrosis Factor alpha (TNFα) and Carcinoembryonic Antigen (CEA), and block their biological functions. As well, I investigated the use of CEA and MUC1 binding aptamers as targeting agents to guide and detect the delivery of contrast agent-loaded liposomes in tumour-bearing mice …
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Engineering antibodies for improved targeting of solid tumors
… ability to specifically bind tumor-expressed antigens. Unfortunately, attempts to treat solid tumors with these drugs are often limited by an inability of the antibodies to fully penetrate the tumor tissue, leaving large regions of untargeted and viable cells. The goal of this thesis is to …
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The pathogenesis of idiopathic pulmonary fibrosis
… into the respiratory epithelium with release of carcinoembryonic antigen (CEA) in peripheral circulation as evidenced by a significant correlation of raised CEA level and lung function impairment in IPF.These findings provide clinical and molecular evidence of novel mechanisms of pathogenesis of …
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Nuclear Factor Kappa B Pathway and human cancer therapeutics
… system to improve the promoter activity of carcinoembryonic antigen (CEA) and human telomerase reverse transcriptase (hTERT) for GDEPT. In this system, the basal CEA promoter sequences were placed downstream of the 4 or 8 NF-κB DNA binding sites linked in tandem (κB4 or κB8). The system was …
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Vergleichende Etablierung und Charakterisierung eines orthotopen Kolonkarzinom-Xenograft-Modells
… were taken on days of autopsy and the CEA (carcinoembryonic antigen) content was determined using an ELISA. The vascularization of the orthotopic primary tumors was examined by staining of CD34, i.e. number and area of the tagged vessels were ascertained. Additionally the green fluorescent …
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Synthesis and Characterization of Multi-Functional Nanoparticles for Therapeutic and Biosensing Applications
… and quantify two different cancer markers — carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) from diluted whole blood or undiluted serum, on a paper-based microfluidic platform. These particles were covalently conjugated with anti-CEA and anti-CA 19-9 antibodies and …
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Development of label-free colorimetric plasmonic sensor for biomedical applications
… of lower concentration of cancer biomarker, carcinoembryonic antigen (CEA) with higher sensitivity, which is discussed in chapter 6. The summary of the thesis with future outlook of the nanoplasmonic biosensor is discussed in chapter 7.
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Molecular analysis and application of tissue microarray technology to the histopathological and immunohistochemical analysis of cervical adenocarcinoma
… sections were immunostained with 8 antibodies, carcinoembryonic antigen (CEA), Cytokeratin7 (CK7), Cytokeratin20 (CK20), estrogen receptor (ER), progesterone receptor (PgR), phosphatase and tensin homolog deleted on chromosome ten (PTEN), MIB-1 proliferation marker, and p53 suppressor gene …
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The dynamics of the serum concentration of CEA, CA15-3 and CA19-9 and survival in patients treated for advanced breast and colorectal cancer. The determination of the prognostic correlates of changes in tumour markers CEA, CA15-3 and CA19-9 during chemotherapy treatment for advanced breast and colorectal cancer.
There is evidence that kinetics of tumour markers (TMs) CEA, CA15-3 and CA19-9 provide valuable information about disease state over time in patients with advanced breast and colorectal cancer but the literature contains differences in methodology so comparing findings is difficult. By modifying …
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