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Showing 1 to 13 of 13 for “"Carboxylesterase"”.
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Characterization of the Plant CXE Carboxylesterase Family
A large family of plant carboxylesterase genes (CXEs) has been identified, which may encode enzymes involved in secondary metabolism (among other potential functions) in higher plants. CXE family members were identified from the model plants Arabidopsis thaliana (20) and Oryza sativa (48), from the …
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A Chemical Approach to the Study of the Juvenile Hormone Carrier Protein and A Specific Carboxylesterase From the Tobacco Hornworm, Manduca Sexta
Made available in DSpace on 2014-12-13T20:10:27Z (GMT). No. of bitstreams: 1 7821230.pdf: 11815092 bytes, checksum: 780e23f9f04d550ec95658b4edf3b2ba (MD5) Previous issue date: 1978
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Biotin synthesis in Escherichia coli
… methyltransferase, whereas BioH has shown carboxylesterase activity. The mechanism by which a methyltransferase and a carboxylesterase catalyze the synthesis of pimelate intermediate was very puzzling. In this Thesis, I describe my approaches to delineate Escherichia coli biotin synthetic …
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NOVEL STRATEGIES FOR IMPROVING THE PHARMACOLOGICAL PROPERTIES OF PLATINUM-ACRIDINE ANTICANCER AGENTS
… and (ii) enzymatic cleavage by human carboxylesterase-2 (hCES-2). Highly efficient amide coupling reactions in platinum complexes were also developed. This modular approach can be used to assemble a diverse library of platinum-acridines containing other bioactive components, such as …
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Bioprospecting novel hemicellulases from the gut microbiota of the common black slug (Arion ater)
… functions described as putative hydrolase and carboxylesterase/phospholipase. BaAXE showed activity on short acyl chains of 4-Nitrophenyl with a specific activity of 78.11 U/mg and Km value of 0.4 mM with 4-Nitrophenyl acetate. BaAXE showed optimum activity at pH 8 and 40 oC. The enzyme showed …
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Design, Synthesis, and Evaluation of Novel Positron Emission Tomography Radiotracers
… is converted in vivo to SN-38, via metabolism by carboxylesterase (CE) enzymes. St. Jude Children’s Research Hospital researchers have designed a two-pronged protocol of tumor-targeted CPT-11 chemotherapy combining the complementary approaches of a) specific modulation of human CE in normal …
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Comparative characterisation of esterases and lipases for biosensors
Twenty four carboxylesterases and lipases from various microbial sources were compared with commercial pig liver esterase in order to determine which would be most appropriate for use in a biosensor application and in the elucidation of the relationship between protein hydration and gas phase …
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Marine bacteria as a source of polyester-degrading enzymes with biocatalytic potential
… (up to 45°C). In chapter 4, MarCE, a marine carboxylesterase was found encoded in the genome of a Maribacter sp. isolated from a sea sponge sample collected at Lough Hyne. MarCE was shown to hydrolyze polycaprolactone diol and putative binding of PET oligomers was demonstrated by molecular …
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Toxicology and herb-drug interaction of selected anti-hypertension plants used by lay persons in Northern KwaZulu-Natal (South Africa)
… inhibition assay as well as the carboxylesterase inhibition assay. These assays were chosen according to the enzymes involved in the metabolism of the hypertension conventional drugs. The overall toxicity profile of the plant extracts tested in BSLA showed that 17 of the organic …
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Neurochemical Effects of Concurrent Exposure to Repeated Stress and Chlorpyrifos on the Central Nervous System
… activities of acetylcholinesterase (AChE), carboxylesterase (Cbxy), and choline acetyltransferase (ChAT), and glutamate and aspartate concentrations. CPF inhibited AChE activity in blood, CC and HP, but stress did not affect AChE activity. Repeated restraint with swim reduced Cbxy and CPF …
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Molecular Considerations In The Design Of Novel Alpha/Beta Hydrolase Inhibitors
… of substrates. A subfamily of ABHs called carboxylesterases (CEs) are important enzymes that catalyze biological detoxification, hydrolysis of certain pesticides, and metabolism of many esterified drugs. The chemotherapy drug irinotecan used for treatment of colorectal cancer is metabolized …
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Dissecting key biomass and adaptation traits of Miscanthus through genetic mapping, exploring mechanisms of cold tolerance, and flowering time in Miscanthus and Saccharum
… hits and two known cold stress related genes, carboxylesterase 13 (CEX13) and WRKY transcription factor (WRKY2). The QTL on LG 11 was also surrounded by one cold shock domain (CDSP1). Many biologically intuitive candidate genes were observed within or near the QTLs and GWA hits detected in this …
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Behavioral and biochemical processing of natural and synthetic xenobiotics in the western honey bee apis mellifera
… been characterized to some extent, the role of carboxylesterases in detoxification of exogenous esters has not yet received attention. Using several natural esters as potential substrates, I investigated whether carboxylesterases, like some detoxifying P450s, vary in activity relative to caste …