Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"Carboxyl Terminus"”.
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Investigating the neuroprotective role of carboxyl-terminus of Hsc70-interacting protein (CHIP) in healthy aging
… and thus are crucial to protein quality control. Carboxyl terminus of Hsp70-interacting protein (CHIP), one such ligase, was initially found to facilitate the polyubiquitination and eventual degradation of aberrantly folded and/or aggregated client proteins in a complex with Hsp70, an essential …
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Small Therapeutic Peptides: In vitro pharmacokinetics of alpha-carboxyl terminus 11 peptide in rat plasma
… they have a very short half-life. Alpha-carboxyl terminus 11 peptide (αCT11) is a 9 amino acid long small peptide that has shown to promote left ventricular function recovery when mouse hearts are perfused with the peptide prior to an ischemia-reperfusion injury. This study investigates …
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Characterization of a Putative Activation Domain in the Hulk Gene Family
… including a proline-rich region (PRR) in the carboxyl-terminus. Based on sequence analysis and the presence of a proline-rich domain, it has been suggested that the HULKs are putative transcription factors in which HUA2 is known to regulate several late-flowering genes: FLC, FLM and MAF2. To …
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Mutagenic Studies of RdoA, a Eukaryotic-Like SER/THR Protein Kinase in Salmonella Enterica Serovar Typhimurium
… not contain a canonical activation loop, its carboxyl terminus is proposed to play a similar regulatory function. Mutations of a putative autophosphorylation target in the carboxyl terminus resulted in loss of in vitro kinase activity. Truncations of this region also resulted in loss of kinase …
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Mechanism of Light Regulation of Rubisco by Rubisco Activase via Thioredoxin -F in Arabidopsis Thaliana
… light activation of ribulose 1,5-bisphosphate carboxylase/oxygenase (Rubisco) in vivo. In most plants examined to date, there are two soforms of Rubisco activase arising from alternative splicing that differ only at the carboxyl terminus. In Arabidopsis the larger isoform has a unique role in …
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Interaction Between Two E3 ligases, NEDD8ylated Cullin and HHARI
… adopting mechanisms of HECT (Homologous to E6-AP Carboxyl Terminus) for substrate ubiquitination. Most well known RBRs include Parkin and HOIP, which are associated with Parkinson’s disease and innate immune deficiency. However, it is not well known how the RBR proteins gain activity, as they are …
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Receptor- G Protein Interactions in the Visual System: A Study of Structures and Mechanisms That Couple the Cytoplasmic Surface of Rhodopsin to the Nucleotide-Binding Pocket of Transducin
… muscarinic receptor. Chimeras in which the amino terminus of C4 was altered were defective in catalyzing Gt activation. A spectroscopic photoregeneration assay was used to demonstrate that mutants of the amino terminus of C4 were defective in binding holo-Gt, a peptide derived from the carboxyl …
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A Critical Role Of Cxcr2 Pdz Motif-Mediated Interactions In Endothelial Progenitor Cell Homing And Angiogenesis
… a consensus PSD-95/DlgA/ZO-1 (PDZ) motif at its carboxyl terminus. The PDZ motif has been reported to regulate cellular signaling and functions. Here we investigated the potential role of the PDZ motif in CXCR2-mediated EPC motility and angiogenesis. We have found that introducing exogenous CXCR2 …
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Targeting of adenovirus serotype 5 infectivity to EGFRvIII-expressing cells using a bispecific CAR-scFv.
… is primarily mediated by binding of the globular carboxyl terminus of its fiber protein, known as the knob domain, to the coxsackievirus and adenovirus receptor (CAR), which is expressed on various cell types. Although we attempted three different approaches to try and target the virus using MR1, …
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Phosphorylation kinetics of cardiac gap junction regulation during stress
… Phosphorylation of residues in the Cx43 carboxyl terminus can alter the subcellular localization, channel gating, and internalization of Cx43. The channel open probability of gap junctions is regulated, in part, by the phosphorylation of S368. Phosphorylation of S365 and S373 have been …
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Structural studies of HIV-1 Vif and its SOCS-box domain
… motif in the SOCS-box binds to the EloB carboxyl terminus by backbone interaction, based on weak van der Waals forces. Based on the results from cell assays it shows that the residues on the Vif proline-rich motif play an important role in viral infectivity; the proline-rich motif induced …
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Expression Of Growth Factor Inducible Genes
… proteins with MRP and TIMP sequences at the carboxyl terminus of {dollar}beta{dollar}-galactosidase were expressed at high levels in E. coli. The purified fusion proteins were used to raise MRP and TIMP specific antisera.;To determine the effect of an upstream overlapping ORF, TIMP …
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Characterization of the Saccharomyces cerevisiae gene MGP1, a novel member of the ras gene superfamily that functions in the mitochondrial biogenesis
… by a mechanism involving modification at its carboxyl terminus. Based on the known functions of such proteins, Mgp1p may serve as part of a signal transduction mechanism involved in communication between mitochondria and the cytosol.</p>
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Molecular Study of Gβγ Dependent Breast Cancer Cell Migration and Invasion
… of Gβγ-sequestering peptide derived from the carboxyl terminus of β-adrenergic receptor kinase (βARKct), attenuates multiple oncogenic pathways, thus suppressing prostate cancer formation and growth. In addition, an inhibitor of the Gα/Gβγ protein complex has been shown to have anti-tumor …
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Characterization of an Interaction Between the Pseudopilin XcpT and the Putative ATPase XcpR in the Type II Secretion System of Pseudomonas Aeruginosa
… leucine mutation at residue 121 located in the carboxyl terminus of this subunit. Additional mutagenesis of a P. aeruginosa K strain containing the xcpTts allele allowed for the isolation of a suppressing mutation located in the amino terminus of the putative ATPase, XcpR. This is the result of …
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The S. cerevisiae calponin homologue SCP1 regulates stability and organization of the actin cytoskeleton
… for actin cross-linking were identified in the carboxyl terminus of Scpl, outside the CH domain. Scpl may regulate actin cytoskeleton not only via direct binding to actin filaments, but also via its interaction with another actin binding protein, Abpl. Scpl and Abpl physically interact in a …
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Molecular genetics and functions of Kaposi's sarcoma-associated herpesvirus glycoproteins in viral entry and virus-induced cell fusion
… glycoprotein in virus entry and the role of the carboxyl tail a-helices of glycoprotein (gB) in virus-induced cell fusion. In addition, a panel of KSHV-glycoprotein mutants was constructed in order to address the specific role of each glycoprotein in viral entry, egress and virus-induced cell …
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Detailed Analysis of Transcriptional Regulation by Activation Functions-1 and -2 of the Human Estrogen Receptor
… and activation function-2 (AF-2) is near the carboxyl-terminus in the E domain. In most cell and promoter contexts, AF-1 and AF-2 act synergistically to allow full transcriptional activity of ER. Our studies were designed to examine the transcriptional activity of ER and focus on both the …
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Genetics and functions of the SARS coronavirus spike protein
… and cluster-to-alanine mutations, as well as carboxyl terminal truncations into the protein and investigating these mutants in transient expression experiments. Mutagenesis of either the coiled-coil domain of the S glycoprotein amino terminal heptad repeat, the predicted fusion peptide, or …
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