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Showing 1 to 6 of 6 for “"Carbohydrate chemistry"”.
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Studies in synthetic carbohydrate chemistry: Part 1. Nitromethane cyclization of sugar polyaldehydes with a view to the synthesis of nitrocyclodextrins. Part 2. Approaches to the synthesis of 2-(R)-fluoro-daunosamine, a carbohydrate moiety for an antitumor drug.
… to synthesize of 2(R )-fluorodaunosamine, a carbohydrate moiety for an antitumor antibiotic 2'-(R)-fluorodaunorubicin, a possible precursor compound, namely methyl 3,6-dideoxy-3-trifluoroacetamido-alpha-L-galactopyranoside was synthesized via periodate oxidation of L-rhamnopyranoside, …
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Development of coupled enzyme assay and in vitro synthetic biology approach for glycosylation pathway characterization
… often face insurmountable hurdles of complex carbohydrate chemistry. To address these challenges, the work undertaken in this thesis was firstly the development of a continuous enzymatic-coupled assay through the redesign of the pyruvate kinase/lactate dehydrogenase (PK/LDH)-coupled assay that …
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Implementing Solvothermally Synthesized Carbon Nanodots into Dye-Sensitized Solar Cells to Enhance External Quantum Efficiency in the Ultraviolet
… CNDs, derived from a fully hydrothermal reflux carbohydrate conversion of D-glucose, both before and after filtration via 20kDa molecular weight cutoff (MWCO) dialysis in water. Synthesis of these CNDs, from the bottom-up hydrothermal method, follows a complex carbohydrate chemistry with …
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Trichloroacetimidates As Outstanding Electrophiles for the Carbon-nitrogen, Carbon-oxygen and Carbon-carbon Bonds Formation and Synthetic Studies of Protein Phosphatase-5 (pp5) Small Molecule Inhibitors
… previously used for glycosidic bond formation in carbohydrate chemistry and in Friedel-Craft reactions. Traditionally, trichloroacetimidates had be synthesized using an alcohol and strongly basic conditions, but in recent years milder preparation methods have been reported. Given the ease of …
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Development of Mono-de-N-acetylated β-(1→6)-N-acetyl-D-glucosamine Substrates for Characterization of PgaB Hydrolase Activity
… The N-terminal domain of PgaB is a family 4 carbohydrate esterase that partially de-N-acetylates PNAG. The C-terminal domain is a family 153 glycoside hydrolase whose role in vivo is not fully understood. This domain can degrade dPNAG-based biofilms, demonstrating the potential for the enzyme …
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CHEMICAL SYNTHESIS AND BIOLOGICAL EVALUATION OF CHONDROITIN SULFATE DISACCHARIDES
Glycosaminoglycans (GAGs) are heterogeneous polysaccharides comprising of repeating uronic acid and amino sugar disaccharide units. Recently, it was shown that the sulfate groups present in chondroitin sulfate GAGs (CS) encode important functional information for the regulation of physiological …