Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Carbapenemase"”.
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EXTENDED-SPECTRUM Β-LACTAMASE-, AMPC- AND CARBAPENEMASE-PRODUCING BACTERIA IN DOGS AND CATS
La resistenza antimicrobica (AMR) rappresenta una delle minacce più critiche per la salute globale, che compromette l'efficacia degli antibiotici e minaccia la salute sia umana che animale. L'aumento di batteri multiresistenti (MDR) mina l'efficacia dei trattamenti per le infezioni negli esseri …
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The genomic characterization of carbapenemase-producing Serratia marcescens at a tertiary hospital in South Africa
… well with phenotypic results. The blaOXA-48-like carbapenemase was the most common carbapenemase identified in 86% (18/21) of CRSM. A core SNP difference tree indicated that the CRSM could be grouped into three clusters. A minority of isolates had shared plasmids. Several genes and single …
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Epidemiology of extended spectrum beta-lactamase and carbapenemase-producing bacteria in stool from apparently healthy children, South Africa
… of extended-spectrum beta-lactamase (ESBL) - and carbapenemase-producing Enterobacteriaceae in healthy humans in the community is largely unknown. We aimed to determine the prevalence and genetic characteristics of ESBL- and carbapenemase-producing Enterobacteriaceae in stools from healthy infants …
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Acquired Carbapenemases in Gram-Negative Bacilli in Singapore
… is due to the introduction of global clones of carbapenemase-producing strains with the potential to cause outbreaks. The diversity of acquired carbapenemase genes in Singapore, their distribution among different species, and some idea of the mechanisms underlying their spread locally are …
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Detection and characterisation of carbapenem-resistant gram-negative bacilli infections in Ghana
… little is known about the nature and spread of carbapenemases in carbapenemresistant (CR) pathogens. The aims of the present study were to detect carbapenemase activity by using simple phenotypic tests, molecular typing to characterise the resistance genes and to determine the relatedness of the …
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Identification of new therapeutic compounds against carbapenemase-producing Klebsiella pneumoniae using a novel agar-based high-throughput microarray compound screening approach
Klebsiella pneumoniae, a Gram-negative bacterium, is a common cause of hospital-acquired pneumonia, urinary tract infections (UTIs), bacteraemia, septicaemia, and wound/surgical site infections. Over the years, the pathogen developed resistance to most β-lactam antibacterial drugs used in clinical …
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Identification and characterisation of cephalosporins and carbapenem-resistant Klebsiella pneumoniae isolates from Misrata, Libya
… beta-lactamase-producing (ESBL) and carbapenemaseproducing Gram-negative bacilli showing resistance to cephalosporins and carbapenems respectively, have been reported from several countries globally and recently among Libyan combatants who have been transferred to European countries …
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Characterization of β-lactamases and Porins in Uropathogenic E. coli
… non-susceptibility in five isolates: three non-carbapenemase producers and two carbapenemase producers. Two of the five isolates, both non-carbapenemase producers, had undetectable levels of OmpC and OmpF on western blot analysis. The other three isolates with detectable porins harbored …
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Antibiotic Resistance Genes in Marquette County Michigan's Wastewater
… OXA-48, VIM, vanA, and mcr-1. Notably, we found carbapenemase genes, so we screened for carbapenemase expression using CARBA-5 NG lateral flow assays, where KPC and OXA-48 screened positive. We opted to use 16Ss rRNA sequencing and MALDI-TOF MS to identify the bacteria expressing carbapenemases, …
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Combatting β-lactamase-mediated antimicrobial resistance: from novel assays for inhibitor discovery to new diagnostics
… diagnostic assays for the rapid detection of carbapenemase-producing Enterobacterales, bacterial pathogens which are resistant to the last-resort carbapenem antibiotics. These assays were validated with a panel of clinical isolates producing carbapenemases that are most commonly encountered by …
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MULTIPLEX ASSAY DESIGN
… end-point PCR reaction for the detection of carbapenemase-producing Enterobacteriaceae (CPE), vancomycin-resistant Enterococcus (VRE) and colistin resistance has been developed in this thesis. The resulting amplicons can be distinguished based on the principles of size, melting-state …
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Studies of the nature of Burkholderia cepacia in cystic fibrosis
… including the carbapenems. Considering this, carbapenemase production by isolates of B. cepacia was investigated. A metallo-β-lactamase from a clinical strain of B. cepacia was isolated and partially purified of using Cibacron blue F3GA-coupled agarose. The resulting preparation showed a …
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Predictors of Carbapenem Resistant Gram-negative Bacteria in a Consortium of Academic Medical Center Hospitals
… to the future utility of the carbapenems are carbapenemase-producing K. pneumoniae Purpose: To determine if there is an association between the volume and composition of antibiotic use, geography, severity of illness and rates of carbapenem-resistant P. aeruginosa and K. pneumoniae. Methods: …
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Characterisation of novel and complex mechanisms of antobiotic resistance using a proteomics approach
… coli</i>. Furthermore, it revealed that non-carbapenemase-mediated carbapenem resistance in <i>K. pneumoniae</i> involved the loss of fimbriae proteins, the increased expression of OmpK26 and the resistance proteins EmrA and APH(3"), in addition to OmpK35/36 porin loss. The upregulation of a …
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Elucidation of the Molecular Mechanisms That Contribute to Variation in Susceptibility Testing Show the Need for Alternative Detection Methods of KPC-producing Gram-negative Bacteria
Pathogens that produce the Klebsiella pneumoniae carbapenemase (KPC) have become a major threat to the global health care system. Patients infected with KPC-producing pathogens have a higher incidence of morbidity and mortality, as these infections have been associated with high levels of β- lactam …
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Investigations of Carbapenem-resistant Klebsiella species and associated clinical considerations
… β-lactamases, AmpC type β-lactamases and carbapenemases combined with porin loss. Carbapenems are the antibiotics of last resort. The emergence of carbapenemase-producing organisms (CPOs) has led to Public Health England introducing a national toolkit to limit their spread. As part of this …
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Defining the Aetiology and Antimicrobial Susceptibility Patterns of the Predominant Bacteria Associated with Bloodstream Infections at the Hospital for Tropical Diseases in Ho Chi Minh City, Vietnam
… genes in <i>Staphylococcus aureus</i>, carbapenemase-resistance genes in Gram-negative bacilli and vancomycin-resistance genes in enterococcus. Asian countries are also burdened with high prevalence of HIV, in which BSI can be a major health problem in these immunocompromised people. …