Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Carbapenem-resistant"”.
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Investigations of Carbapenem-resistant Klebsiella species and associated clinical considerations
… quinolones, aminoglycosides, cephalosporins and carbapenems. Resistance to β-lactams is mediated via extended-spectrum β-lactamases, AmpC type β-lactamases and carbapenemases combined with porin loss. Carbapenems are the antibiotics of last resort. The emergence of carbapenemase-producing …
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Threat of Carbapenem Resistant Enterobacteriaceae and the Rise of Antibiotic Resistance
… threat to human health. Among these antibiotic resistant microbes, Carbapenem Resistant Enterobacteriaceae (CRE) are of particular concern. CRE infections have a relative mortality rate of 50% (Guh et al., 2013). While containing Carbapenem inactivating enzymes, horizontal gene transfer is a …
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Detection and characterisation of carbapenem-resistant gram-negative bacilli infections in Ghana
… little is known about the nature and spread of carbapenemases in carbapenemresistant (CR) pathogens. The aims of the present study were to detect carbapenemase activity by using simple phenotypic tests, molecular typing to characterise the resistance genes and to determine the relatedness of the …
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Invitro antibacterial activity of imidazole and triazole-based antimicrobials against Carbapenem Resistant Enterobacteriaceae
Thesis submitted in fulfilment of the requirements for the degree of Masters of Technology: Biomedical Technology, Durban University of Technology, Durban, South Africa, 2017.
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Identification and characterisation of cephalosporins and carbapenem-resistant Klebsiella pneumoniae isolates from Misrata, Libya
… beta-lactamase-producing (ESBL) and carbapenemaseproducing Gram-negative bacilli showing resistance to cephalosporins and carbapenems respectively, have been reported from several countries globally and recently among Libyan combatants who have been transferred to European countries …
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Predictors of Carbapenem Resistant Gram-negative Bacteria in a Consortium of Academic Medical Center Hospitals
… It is generally believed that rates of resistant bacteria within a hospital are a function of antibiotic use, resistant organisms brought into the hospital, infection control efforts, and underlying severity of patient illness. The relative contribution of each to a particular resistance …
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Colonisation with extended spectrum beta-lactamase producing and carbapenem-resistant enterobacterales in children admitted to a paediatric referral hospital in South Africa
… Enterobacterales (ESBL-PE) and carbapenem-resistant Enterobacterales (CRE) among children in subSaharan Africa. Colonisation often precedes infection and multi-drug-resistant Enterobacterales are important causes of invasive infection. Methods: In this prospective cross-sectional …
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Investigation of Biofilm Development by Antibiotic Resistant Urinary Tract Infection Pathogens and Evaluation of the Antimicrobial Activity of Natural Products on Carbapenem-Resistant Escherichia coli IMP and Klebsiella pneumoniae NDM-1.
… β-lactamase (ESβL) producing bacteria, including Carbapenem-Resistant Enterobacteriaceae (CRE), are becoming increasingly prevalent worldwide. Understanding the biology behind the ability of these pathogens to form biofilms is crucial to the treatment of the infections caused by these pathogenic …
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Acquired Carbapenemases in Gram-Negative Bacilli in Singapore
This thesis hypothesised that the increase in carbapenem-resistance in Gram-negative bacilli in Singapore is due to the introduction of global clones of carbapenemase-producing strains with the potential to cause outbreaks. The diversity of acquired carbapenemase genes in Singapore, their …
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Strengthening Antibiotics Stewardship At Mowbray Maternity – Neonatal Unit
… eight organisms (18.9%), which included one Carbapenem-resistant enterococci -Klebsiella pneumoniae. For HH, a total of 444 opportunities were observed. Moment 5 had the lowest overall mean compliance of (57.4%), which was statistically significant with a p-value =0.0172. The overall HH …
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Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteria
… coli and other ESKAPE pathogens (including carbapenem-resistant Acinetobacter baumannii). Interestingly, these analogues were resistant to enzymatic degradation in the presence of recently reported D-stereoselective peptidases. <br/><br/>Secondly, brevicidine represents a promising candidate …
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The genomic characterization of carbapenemase-producing Serratia marcescens at a tertiary hospital in South Africa
… organism. There is a paucity in genomic data for carbapenem resistant S. marcescens (CRSM). Methods A retrospective cohort study describing laboratory confirmed CRSM from a tertiary academic hospital in Cape Town, South Africa, for the period 2015-2020, was performed. Stored CRSM and control …
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The effect of environmental stress on antibiotic production by streptomyces
… presented activity against a clinical isolate of carbapenem-resistant Acinetobacterbaumannii. In Addition, Streptomyces puniceus presented a unique morphology that was not seen before in Streptomyces. Moreover, elicitation of bio-active compounds from antimicrobial-producing isolates was achieved …
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Mobilome and antibiotic resistance in Acinetobacter baumannii
… cephalosporins (such as ceftazidime) and carbapenems (such as imipenem and meropenem) represent important treatment options for infections caused by this microorganism. Nevertheless, the number of strains resistant to these antibiotics has been increasing during the last decade. The …
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Impact of Wastewater Effluent on Surface Water Resistomes in a Small Lower-Income Community with Deteriorated Sewage Infrastructure
… selective pressure favoring the development of resistant bacteria and antibiotic resistance genes (ARGs). Consequently, this has led to a global antimicrobial resistance (AMR) crisis associated with an estimated 4.71 million deaths globally in 2021. Due to inputs of antimicrobials and …
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Urinary tract infection in children at Victoria Hospital, a district hospital in Cape Town, South Africa
… beta lactamase-producing organisms but no carbapenem-resistant organisms were isolated. Conclusion: Although this study did not evaluate clinical outcomes of children, the AST finding that only 58% of Enterobacterales isolates were susceptible to the recommended empiric treatment with …
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Extended-Spectrum Beta-Lactamase-Producing Enterobacteriaceae: Epidemiology, Risk Factors, and Duration of Carriage
… products. The rapid increase and spread of the carbapenem-resistant NDM-1-producing Enterobacteriaceae, especially in India and the Middle East, plainly illustrates that the current antibiotic situation is very precarious, and that it is essential to continue development of new antibiotics. The …
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Regulation of Outer Membrane Porins in P. aeruginosa Strains Collected from Patients with Cystic Fibrosis
… sought to determine how P. aeruginosa emerges resistant to antibiotics and how specific porins are regulated under different growth conditions typically found in the CF lung environment. It was hypothesized that the regulation of antibiotic resistance determinants and outer membrane porins of …
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