Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Carbapenem"”.
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Investigations of Carbapenem-resistant Klebsiella species and associated clinical considerations
… quinolones, aminoglycosides, cephalosporins and carbapenems. Resistance to β-lactams is mediated via extended-spectrum β-lactamases, AmpC type β-lactamases and carbapenemases combined with porin loss. Carbapenems are the antibiotics of last resort. The emergence of carbapenemase-producing …
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Threat of Carbapenem Resistant Enterobacteriaceae and the Rise of Antibiotic Resistance
… Among these antibiotic resistant microbes, Carbapenem Resistant Enterobacteriaceae (CRE) are of particular concern. CRE infections have a relative mortality rate of 50% (Guh et al., 2013). While containing Carbapenem inactivating enzymes, horizontal gene transfer is a powerful force …
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The postantibiotic effect of the carbapenem antibiotics on gram-negative bacteria
… by a wide variety of microorganisms. At present, carbapenems and penems are the only members of the -lactam group of antimicrobial agents that exhibit a significant PAE on Gram-negative bacilli. A standardised method was developed to evaluate the in vitro PAE of three carbapenems; imipenem, …
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Detection and characterisation of carbapenem-resistant gram-negative bacilli infections in Ghana
… little is known about the nature and spread of carbapenemases in carbapenemresistant (CR) pathogens. The aims of the present study were to detect carbapenemase activity by using simple phenotypic tests, molecular typing to characterise the resistance genes and to determine the relatedness of the …
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Invitro antibacterial activity of imidazole and triazole-based antimicrobials against Carbapenem Resistant Enterobacteriaceae
Thesis submitted in fulfilment of the requirements for the degree of Masters of Technology: Biomedical Technology, Durban University of Technology, Durban, South Africa, 2017.
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Identification and characterisation of cephalosporins and carbapenem-resistant Klebsiella pneumoniae isolates from Misrata, Libya
… beta-lactamase-producing (ESBL) and carbapenemaseproducing Gram-negative bacilli showing resistance to cephalosporins and carbapenems respectively, have been reported from several countries globally and recently among Libyan combatants who have been transferred to European countries …
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Predictors of Carbapenem Resistant Gram-negative Bacteria in a Consortium of Academic Medical Center Hospitals
… infections and it may become resistant to carbapenems. In addition, newer threats to the future utility of the carbapenems are carbapenemase-producing K. pneumoniae Purpose: To determine if there is an association between the volume and composition of antibiotic use, geography, severity of …
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Carbapenem and piperacillin-tazobactam prescribing in a hospital setting in Kingdom of Saudi Arabia : a mixed methodology study
… study,which included adult patient data on carbapenems (imipenem/cilastatin ormeropenem) and piperacillin/tazobactam use retrieved from a hospital database forthe period from 1 January 2016 to 31 December 2017, was conducted followed by aqualitative study of physicians' views and perceptions …
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Identification of novel regulators of the necrosis-inducing protein (Nip) and carbapenem antibiotic production in the phytopathogen Pectobacterium
… Some strains also produce a simple β-lactam carbapenem antibiotic, 1-carbapen-2-em-3-carboxylic acid. This carbapenem cluster is cryptic in several strains of Pectobacterium but can be activated by introduction of its cognate regulator gene, carR, if provided in trans. Pectobacterium is also …
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Effects of Anaerobic and Aerobic Digestion at Mesophilic and Thermophilic Temperatures on the Quantity of Carbapenem Resistance Genes in Wastewater Sludge
… resistance against antibiotic drugs in bacteria. Carbapenem antibiotics are one of the last lines of defence against bacterial infections and carbapenem resistance genes (CRGs) accumulate in sludge during wastewater treatment. Anaerobic and aerobic digestions are commonly used for sludge …
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Colonisation with extended spectrum beta-lactamase producing and carbapenem-resistant enterobacterales in children admitted to a paediatric referral hospital in South Africa
… Enterobacterales (ESBL-PE) and carbapenem-resistant Enterobacterales (CRE) among children in subSaharan Africa. Colonisation often precedes infection and multi-drug-resistant Enterobacterales are important causes of invasive infection. Methods: In this prospective cross-sectional …
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New Pleiotropic Co-Regulators of Gas Vesicle and Secondary Metabolite Production in Serratia sp. ATCC39006
… antibiotic, 1-carbapen-2-em-3-carboxylic acid (a carbapenem). The production and regulation of GV assembly is a complex process, which is part of a wider regulatory network affecting various phenotypes, including the carbapenem and prodigiosin antibiotics. The present study aimed to identify genes …
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Acquired Carbapenemases in Gram-Negative Bacilli in Singapore
This thesis hypothesised that the increase in carbapenem-resistance in Gram-negative bacilli in Singapore is due to the introduction of global clones of carbapenemase-producing strains with the potential to cause outbreaks. The diversity of acquired carbapenemase genes in Singapore, their …
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Outer Membrane Porin Regulation among Different Sequence Types of Escherichia coli Clinical Isolates
… in permeability correlate with decreased carbapenem susceptibility when the organism produces an extended-spectrum β-lactamase or plasmid-encoded AmpC. Altering the production of porins could impact the fitness, and therefore the success of ST131 E. coli. The experiments described in this …
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Novel pleiotropic regulators of flotation, secondary metabolite production, and virulence in Serratia sp. ATCC 39006
… β-lactam, 1-carbapen-2-em-3-carboxylic acid (a carbapenem) and the red-pigmented tripyrrole, 2-methyl-3-pentyl-6-methoxyprodigiosin (prodigiosin; a prodiginine). It also produces plant cell wall degrading enzymes (PCWDEs) and is capable of flagellar-mediated swimming and swarming motility. …
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Investigation of Biofilm Development by Antibiotic Resistant Urinary Tract Infection Pathogens and Evaluation of the Antimicrobial Activity of Natural Products on Carbapenem-Resistant Escherichia coli IMP and Klebsiella pneumoniae NDM-1.
… β-lactamase (ESβL) producing bacteria, including Carbapenem-Resistant Enterobacteriaceae (CRE), are becoming increasingly prevalent worldwide. Understanding the biology behind the ability of these pathogens to form biofilms is crucial to the treatment of the infections caused by these pathogenic …
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Mobilome and antibiotic resistance in Acinetobacter baumannii
… cephalosporins (such as ceftazidime) and carbapenems (such as imipenem and meropenem) represent important treatment options for infections caused by this microorganism. Nevertheless, the number of strains resistant to these antibiotics has been increasing during the last decade. The …
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Novel pleiotropic regulators of gas vesicle biogenesis in Serratia
… sp. ATCC 39006 (S39006) is known for producing carbapenem and prodiginine antibiotics; 1-carbapen-2-em-3-carboxylic acid (car) and prodigiosin. It displays different motility mechanisms, such as swimming and swarming aided by flagellar rotation and biosurfactant production. In addition, S39006 …
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