Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"Carbamazepine"”.
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Carbamazepine and its metabolites in epileptic patients
Carbamazepine is a drug which is now widely used for the treatment of both generalised epilepsy (tonic-clonic seizures) and partial epilepsy (with simple or complex symptomatology). This study was undertaken in an attempt to assess the role of the metabolites of carbamazepine, viz. 10, …
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The Mechanisms, Products, and Kinetic of Carbamazepine-Free Chlorine Reactions
Carbamazepine (CBZ) is an antiepileptic drug widely detected in drinking water supplies and wastewater effluent. It has been previously found that CBZ is recalcitrant to biological removal processes. Therefore, active CBZ will be exposed to wastewater effluent disinfection processes, which for most …
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Effects of Polymers on Carbamazepine cocrystals phase transformation and release profiles
… of cocrystals. Pharmaceutical cocrystals of Carbamazepine (CBZ) (namely 1:1 carbamazepine-nicotinamide (CBZ-NIC), 1:1 carbamazepine-saccharin (CBZ-SAC) and 1:1 carbamazepine-cinnamic acid (CBZ-CIN) cocrystals, were synthesized. A Quality by Design (QbD) approach was used to construct the …
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Using an In Vitro-In Vivo Correlation for the ‘Bioequivalence by Design’ Development of an Immediate Release Carbamazepine Product
… product for this work was an immediate release carbamazepine tablet. Carbamazepine was selected as the model active pharmaceutical ingredient because it has a narrow therapeutic index and is designated as a class II compound (i.e. high permeability, low solubility) according to the FDA’s …
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Neural tube defects in rodents caused by a tap water contaminant
… drug used to treat mood disorders and seizures: carbamazepine. Further analysis for carbamazepine was conducted in-house. Carbamazepine was found in several ground, surface, and tap waters, at various concentrations. To establish whether or not carbamazepine was responsible for NTDs in our mice, …
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Examination of stress-induced transformations within multicomponent pharmaceutical crystals
… and sublimation. The chapter also introduces carbamazepine (CBZ) multicomponent materials as models for the studies of stress-induced transformations. Chapter 2 presents the experimental section of the work and describes the materials, methods and equipment used for the study. Chapter 3 …
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Novel Methods for Co-crystallisation
… was developed for co-crystallisation of carbamazepine / saccharin co-crystal pair and demonstrated its application for polymorphic control and as a potential technique for the purification of desired crystal form through surface energetic based separation. The thermodynamic …
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Pharmaceutical occurrence, distribution and degradation in rural wastewaters and surface waters in Scotland
… clarithromycin and trimethoprim (antibiotics); carbamazepine and fluoxetine (psychoactive drugs); and 17α-ethynylestradiol (synthetic hormone).<br/>Overall, results suggest that the studied rural community produced wastewater with significant concentrations of the target compounds. Paracetamol …
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Applications of ultrasound in pharmaceutical processing and analytics.
… co-crystallisation of caffeine / maleic acid and carbamazepine / saccharin was investigated. To validate low power ultrasound monitoring technique, it was compared with the other techniques (PAT tools) such as in-line rheology and in-line NIR spectroscopy. In-line rheological measurements were …
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Health technology assessment for levetiracetam in the treatment of newly diagnosed epilepsy in the South African Public Health Sector
… analysis which are levetiracetam, lamotrigine, carbamazepine, phenytoin and valproate. The current first-line epilepsy treatment in South Africa is lamotrigine, phenytoin or carbamazepine. Levetiracetam is under consideration for use as a first-line treatment due to the reported minimal serious …
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Forecasting the Transport and Fate of Pharmaceuticals in Coarse Grained Aquifers
… in groundwater were selected for evaluation: carbamazepine, caffeine, gemfibrozil, ibuprofen, naproxen and sulfamethoxazole. Within the course of the project additional compounds were added to the analyses: nicotine, cotinine, ecstasy, methylated ecstasy, and cocaine. Batch sorption …
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Forecasting the Transport and Fate of Pharmaceuticals in Coarse Grained Aquifers
… in groundwater were selected for evaluation: carbamazepine, caffeine, gemfibrozil, ibuprofen, naproxen and sulfamethoxazole. Within the course of the project additional compounds were added to the analyses: nicotine, cotinine, ecstasy, methylated ecstasy, and cocaine. Batch sorption …
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Mechanistic Understanding of Co-crystal solubility and dissolution by using a combination of Experimental and Molecular Modelling Techniques
… at molecular level of Flufenamic acid and Carbamazepine co-crystals in the presence of polymers. This study has been separated into four sections: (1) Formation of pharmaceutical co-crystals: Three pharmaceutical co-crystals of poorly water soluble active pharmaceutical ingredient (API) of …
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Characterization and application of human pluripotent stem cell-derived neurons to evaluate the risk of developmental neurotoxicity with antiepileptic drugs in vitro
… major AEDs, namely phenobarbital, valproic acid, carbamazepine and lamotrigine, on cell viability, cell cycle and differentiation of TERA2.cl.SP-12 into neurons was studied. All AEDs tested reduced differentiating stem cell viability. Valproic acid and carbamazepine increased apoptosis and reduced …
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REMOVAL OF EMERGING CONTAMINANTS FROM AQUEOUS SOLUTION BY OZONE -BASED PROCESSES
… sulfamethoxazole, trimethoprim and carbamazepine have been selected. The effect of different process parameters such as chemical dosages, ozone weight percent, ozone flow rates, etc. on destruction of ECs were examined. It was observed that 1, 4-dioxane were persistent to direct …
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Discriminative Stimulus Effects of Gabapentin
… produced full substitution, while pregabalin, carbamazepine, fentanyl, and buspirone produced partial substitution (≥ 60% gabapentin-lever responding) for gabapentin. Ethanol and raclopride did not substitute for gabapentin. The psychostimulant amphetamine did not produce substitution; however, …
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Solvent Free Technologies for Polymer based Crystal Engineering and Drug Delivery
… chosen for the solid dispersion purpose were carbamazepine, ibuprofen, glibenclamide which are BCS class II drugs and paracetamol from BCS class III drug was selected as model drug for solid dispersion manufacturing with PVP. VA64, HPMCP HP55, HPMCAS, Ethyl cellulose as polymers. In case of …
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The use of scintigraphy to study gastric emptying, motility and small intestinal transit in patients who have ingested a selection of common poisons
… overdoses of tricyclic antidepressants (n = 31), carbamazepine (n = 15), phenytoin (n = 12), paracetamol (n = 29) and opioid-paracetamol mixtures (n = 17). They received standard hospital management of which sorbitol was not a part. Part 2 consisted of sixty-one patients who had sorbitol added to …
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Investigating human pharmaceutical compounds present in municipal and hospital wastewaters and options for their removal
… naproxen and bezafibrate (> 1 μg/L), followed by carbamazepine, atenolol, lidocaine, sulfamethoxazole and NACS (<1 μg/L). In hospital wastewater treatment plants (HWWTPs), the highest concentrations measured were for paracetamol and caffeine (> 10 μg/L), followed by ciprofloxacin and NACS (1–6 …
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Investigation of a solvent-free continuous process to produce pharmaceutical co-crystals. Understanding and developing solvent-free continuous cocrystallisation (SFCC) through study of co-crystal formation under the application of heat, model shear and twin screw extrusion, including development of a near infrared spectroscopy partial least squares quantification method
… Ibuprofen – nicotinamide 1:1 cocrystals and carbamazepine – nicotinamide 1:1 co-crystals were successfully manufactured using the SFCC method. Characterisation techniques were important for this project, and NIR spectroscopy proved to be a convenient, accurate analytical technique for …
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