Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Capsular polysaccharide (CPS)"”.
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Synthesis of fragments of the capsular polysaccharide of <i>Neisseria meningitidis</i> (serogroup A) suitable for bioconjugation
… factor of this bacterium is the presence of a capsular polysaccharide (CPS) and apart from being an important surface antigen, also protects the bacteria cells against phagocytosis by the host’s immune defense. The CPS structure of the serotype A is the (1-6)-linked …
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Antimicrobial Carbohydrate Vaccines: Development of Burkholderia pseudomallei immunogens
… experiments in mice have demonstrated that the capsular polysaccharide (CPS-1) of B. pseudomallei, which is composed of β-1,3-linked 6-deoxy-D-manno-heptopyranose residues, is a promising candidate for vaccine development. This thesis set out to explore routes to potential vaccine candidates for …
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ENGINEERING PHAGE HOST RANGE PROMISCUITY
… Salmonella Typhi has been identified as the Vi capsular polysaccharide (CPS). This study aimed to develop a promiscuous phage receptor expression system allowing infection in a broad range of heterologous hosts. The S. Typhi Vi CPS biosynthetic operon was cloned into a broad host range cosmid …
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Synthetic studies toward 6-deoxy-ß-D-ido-heptopyranosides related to capsular polysaccharides of Campylobacter jejuni
… of antibodies elicited against the bacterial lipopolysaccharides that can cross-react with human gangliosides present on nerve tissue, resulting in neurological complications (e.g. acute paralysis) from immune-mediated destruction of the nervous system. The capsular polysaccharide (CPS) of C. …
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Structural analysis of capsular polysaccharides produced by some emerging Klebsiella pneumoniae serotypes
… Organisation (WHO). K. pneumoniae produces a capsular polysaccharide (CPS or Kantigen), which constitutes an important virulence factor and a potential vaccine antigen. To date, there are up to 77 known distinct K. pneumoniae K-antigen serotypes, that have been classified through serotyping. …
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Chemical and conformational studies of bacterial cell surface polysaccharide repeating units
Abstract Bacterial cell surface polysaccharides are primarily present as lipopolysaccharides or capsular polysaccharides. They are used by cells for both structure and function and have been shown to be a virulence factor of bacterial pathogens. Cell surface polysaccharides are widely utilised as …
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An investigation towards a conjugate vaccine against Streptococcus pneumoniae serotype 19A
… vaccines comprised of the bacterial surface polysaccharide conjugated to a carrier protein are very effective in protecting young children against disease by inducing immunological memory and reducing carriage of the bacteria. A pneumococcal conjugate vaccine against seven serotypes (PCV7) …
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Antibody-based diagnostics and therapeutics for Zaire ebolavirus and Burkholderia pseudomallei
… chimeric antibody specific to B. pseudomallei capsular polysaccharide (CPS) was developed. This is important because it could potentially be used as a prophylaxis treatment for melioidosis. A murine monoclonal antibody (m4C4) that binds to B. pseudomallei CPS was previously developed by our …
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Modified heptose synthesis in the Campylobacter jejuni capsule and its involvement in virulence
Campylobacter jejuni is the leading cause of gastroenteritis.Infections are endemic in developing countries and the emergence of antibiotic resistant isolates in developed countries underline the requirement for new therapeutic targets. C. jejuni possesses a capsule, which is important in …
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Development of Diagnostic Assays for Melioidosis, Tularemia, Plague and COVID19
… of plague: low-calcium response V (LcrV) and capsular fraction-1 (F1). A total of twenty-two high affinity monoclonal antibodies (mAbs) were isolated from BALB/c mice immunized with recombinant LcrV, F1 and LcrV-F1 fusion protein via hybridoma technology. mAbs were characterized by Western …