Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 72 for “"Capsid protein"”.
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Modulation of West Nile Virus Capsid Protein and Viral RNA Interaction through Phosphorylation
… the interaction between WNV viral RNA and the capsid (C) protein and also elucidate how the processes of nucleocapsid assembly are regulated. Initial in vitro C protein and viral RNA interaction studies showed that this interaction was not specific. This suggested the presence of a regulatory …
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Structural Studies On The Rubella Virus Capsid Protein And Its Organization In The Virion
… to its alphavirus relatives. The rubella capsid protein is a critical structural component of virions as well as a key factor in virus-host interactions. Three crystal structures of the structural domain of the rubella capsid protein have been described here. The polypeptide fold of the …
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The Lipid-Containing Bacteriophage PR4: Posttranslational Processing of the Major Capsid Protein and Lipid Selection in Particle Assembly
… that contains lipid bilayer membrane within its protein capsid. The hosts include Escherichia coli and Salmonella typhimurium.
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Investigation of the use of recombinant BCG, expressing the major capsid protein (LI) of human papillomavirus type 16, as a candidate vaccine for cervical cancer
Includes bibliographical references (leaves 214-236).
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Plant production and immunogenic characterisation of Human papillomavirus chimaeric vaccines
… the cervical cancer burden. Current HPV L1 major capsid protein virus-like particle (VLP)-based vaccines are effective in the type-specific prevention of infection and associated disease. However, the high cost of the vaccines has limited their widespread application, and cytological screening …
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Virus-mimetic structures through protein engineering and nucleic acid origami
… have intriguing biological properties. Their proteinaceous capsids are uniform in size and shape and serve to protect the viral genome and gate the flux of small molecules. Combined with their unique self-assembly properties, viruses have gained attention as versatile building blocks for …
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Intracellular sensor spatial multiplexing via RNA scaffolds
… Each sensor is fused to an orthogonal viral capsid protein that binds to a long, repetitive strand of its corresponding RNA sequence. All sensors fluoresce green and are indistinguishable during recording but are identified with post-hoc antibody or FISH staining for each sensor-specific …
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Using single cell RNA sequencing to assess immunological responses in quails injected with porcine circovirus-like particles
… circular DNA genome that encodes the single capsid protein (CP) as well as a replication-associated protein. The impacts of infection with PCV-2 have had devastating effects on the swine industry, causing major stress to the socio economic state of many countries, and therapies are needed. …
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Genetic and Biochemical Analyses of the Flaviviridae Capsid Proteins
… particles, thought to arise by budding of the capsid protein and associated genomic RNA through a host cell-derived lipid membrane outfitted with envelope glycoproteins. The process of virion morphogenesis is not well understood, but the presumed involvement of numerous viral and cellular …
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Molecular mechanisms of porcine circovirus 2 replication and pathogenesis
… role of 2 amino acid substitutions in the PCV2 capsid protein in PCV2 attenuation, evaluate the effect of Rep gene exchange between PCV1 and PCV2 on growth characteristics of a chimeric PCV2, and evaluate the role of open reading frame (ORF) 3 of PCV2 in virus replication and pathogenesis in …
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The Tradeoffs for a Viral Mutant with Enhanced Replication Speed
… We found that a single mutation in a viral capsid protein, VP1-F106L, was sufficient for the fast-replication phenotype. Characterization of this mutant revealed quicker genome release during entry compared to wild-type virus, highlighting a previously unappreciated infection barrier. …
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Development of Rapid Lateral-flow Immunochromatographic Test for the Diagnosis of Chikungunya Virus Infection
… METHODS: Three CHIK virus structural recombinant proteins, capsid protein and, E1 and E2 envelope glycoproteins, were produced in the baculovirus expression system. Using these recombinant proteins, indirect ELISA and LF-ICT were established for detection of IgM against CHIK virus capsid protein, …
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Engineering M13 bacteriophage platforms for cancer therapy applications
… of small viral ssDNA that are packaged by M13 capsid proteins. These 'inho' phages can be sized to ~50nm and above in length. The small phage retains the M13 major and minor coat proteins which have previously been manipulated to serve as tethers to carry various therapy and imaging agents and …
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Role of Microtubule Motor Proteins in Adenoviral Infections
… the bad news can be reduced to the viral capsid. The adenoviral capsid mainly consists of three proteins (fiber, penton base, hexon) that form a rigid shell to protect the viral genome outside of host cells. However, they are able to orchestrate a precise disassembly program initiated once …
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Immunogenic assessment of plant-produced Human papillomavirus type 16 chimaeric L1:L2 virus-like particles and the production of an encapsidated therapeutic DNA vaccine candidate
… are based on the immunodominant L1 major capsid protein, which assembles into virus-like particles (VLPs) that are highly effective in type-specific prevention of cervical infection. However, these vaccines are produced in expensive cell culture systems, are type-specific and do not induce …
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Beak and feather disease virus candidate vaccine development
… of the BFDV's major antigenic determinant, the capsid protein (CP), in the inexpensive and highly scalable plant expression system, could satisfy these requirements as a potential subunit vaccine. In this work, truncated CP (ÄN40 CP) was first expressed in E. coli to successfully generate …
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Molecular characterization of human sapoviruses circulation in the rural communities of Limpopo Province, South Africa
… the genotypes, characterize, and analyze a capsid protein of the detected human Sapovirus strains associated with diarrhoea in children less than 5 years of age from rural communities in SA, and also compare the detected SV strains in this study with other strains reported elsewhere around …
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Molecular Study of the B19 (Human) Pathogenic Parvovirus
… marrow. Replication of viral DNA and the viral protein products of B19 appear similar to those of other animal parvoviruses. However, B19 differs from other parvoviruses in some important aspects, which include the initiation of all transcripts at a strong left side promoter (p6) and the absence …
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Reaching Across the Divide: Tools for Bridging Structural and Viral Genomics Using a Combination of Biophysical Principles and Machine Learning
… lack similarity with current nucleotide and protein databases. New predictive methods are thus necessary to determine the phenotype of viruses. In this work, we leverage the physical geometrical constraints of viruses to quantify the correlation between the geometric and genomic …
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