Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 5 of 5 for “"Capsazepine"”.
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Transient receptor potential vanilloid 1 exhibits neuroprotective effects in LPS-induced dopaminergic neuronal death in the suabstantia nigra in vivo.
… This neuroprotective effect was reversed by capsazepine, a TRPV1 antagonist, indicative of TRPV1 involvement. However CAP could not block the infiltration of peripheral immune cells. Based on these results, we found that CAP exhibits the neuroprotective effects through regulating the immune …
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Antiproliferative activities of Euphorbia bicolor (euphorbiaceae) and Maclura pomifera (moraceae) extracts on estrogen receptor-positive and triple-negative breast cancer cell lines
… leading to apoptosis. Blocking TRPV1 with capsazepine and using the calcium chelator BAPTA-AM rescued cell viability, confirming the role of TRPV1. The extracts activated multiple apoptotic pathways, including mitochondrial, ERK-induced, and endoplasmic reticulum stress-mediated apoptotic …
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Microvascular inflammatory response in the skin
… after skin prick test. Co-application of capsazepine inhibited the response. The results indicate a role for anandamide as a pararcrine signalling molecule and demonstrates the utility of skin prick test and laser Doppler perfusion imaging as a means of studying local, haemodynamic effects …
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Studies on transient receptor potential vanilloid subtype 1 (TRPV1)-mediated degeneration of mesencephalic cellsin vivo and in vitro
… effect was ameliorated by the TRPV1 antagonist capsazepine (CZP) or iodo-resiniferatoxin (I-RTX), suggesting the direct involvement of TRPV1 in neurotoxicity. In cultures, both CAP and anandamide (AEA), an endogenous ligand for both TRPV1 and cannabinoid type 1 (CB1) receptors, induced …
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Studies on the Mechanism of Polyamine-and Prothrombin kringle-2-induced Degeneration of Neuron and Microglia
… of Polyamines in neurotoxicity. TRPV1 antagonist capsazepine (CZP) reversed 6-OHDA-or polyamines-induced loss of DA neurons in vivo and in vitro, indicating TRPV1-mediated neurotoxicity. Western blot analysis also showed that pretreatment with DFMO reversed 6-OHDA-induced downregulation of …