Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Canonical WNT pathway"”.
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Role of Wnt signaling in proliferation of human bone marrow-derived mesenchymal stem cells
… Wingless-related MMTV integration site (Wnt) is well known signaling molecules that implicated in mesenchymal differentiation during development, but the role in proliferation of hMSCs is not well known. In this study, we investigated the effect of Wnt signaling molecules on the …
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Eukaryotic protein mimicry as an infection strategy for Ehrlichia chaffeensis
… We recently reported that E. ch. activates canonical Wnt signaling in monocytes to promote bacterial uptake and intracellular survival and that TRP120 was involved in this activation event. To identify the specific mechanism of pathway activation, we hypothesized that TRP120 is a Wnt …
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The Role of Wnt Signaling in Development of the Ophthalmic Trigeminal Placode.
… been well described. This study identifies the canonical Wnt signaling pathway as a regulator of opV trigeminal placode development. Introducing dominant-negative TCF and dominant-active β-catenin expression constructs by in ovo electroporation, we have manipulated the canonical Wnt pathway …
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Control of proliferation in human mesenchymal stem cells by Secreted Frizzled Related Protein 1
… would like to confirm the relationship between Wnt signaling and proliferation of hMSCs. When checked mRNA expression of various genes that were related to Wnt signaling, most of genes were decreased gradually as follow passages, except Wnt11. Especially, gene expression of sFRP1, an antagonist …
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Mechanisms Regulating The P120-Catenin/Kaiso Pathway
<p> <p> The Wnt pathways contribute to many processes in cancer and developmental biology, with β-catenin being a key canonical component. P120-catenin, which is structurally similar to β-catenin, regulates the expression of certain Wnt target genes, relieving repression conferred by the POZ/ …
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Interactions between BMP and Canonical Wnt Signaling Regulate Critical Stages of the Osteoblast Lifecycle
… mechanistic information about other signaling pathways that can potently stimulate osteoblast differentiation and/or function. A wealth of genetic evidence in humans and mice clearly demonstrates that the canonical Wnt pathway is intimately involved in skeletal development and post-natal bone …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
… APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. Further studies have suggested that APC plays important roles in several other cellular processes, including cell adhesion and migration, organization of actin and microtubule networks, spindle …
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Identification of Small Molecule Inhibitors Targeting Truncated Adenomatous Polyposis Coli (APC) as a Novel Therapeutic Strategy in Colorectal Cancer
… APC primarily acts as a negative regulator of Wnt pathway by aiding in degradation of β-catenin. Further studies have suggested that APC plays important roles in several other cellular processes, including cell adhesion and migration, organization of actin and microtubule networks, spindle …
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New Insights into the Regulatory Network Controlling Neuroblast Migration in C. elegans
… of the Q neuroblasts is divided into two control pathways, consisting of short-range initial migrations, followed by long-range migrations. The initial migrations are controlled via a Wnt-independent pathway. Both QR and QL are born between the hypodermal seam cells V4 and V5. Between 3 hours to …
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Bone and Cartilage Regeneration: Wnt Signaling Pathway in Healing
The Wnt signaling pathway plays a central role in bone and cartilage embryonic development, processes that are recapitulated during regeneration. Imbalance in such well conserved and complex system often contributes to numerous diseases, whereas controlled modulation of the Wnt signaling activity …
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P120-Catenin Regulates Rest and Corest, and Modulates Mouse Embryonic Stem Cell Differentiation
<p>The canonical-Wnt pathway and beta-catenin have been extensively studied to determine their contributions to stem cell biology, but less is known about p120-catenin in the nuclear compartment. P120 is developmentally required as a consequence of its biochemical and functional interactions with …
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Local Wnt11 Signalling and its role in coordinating cell behaviour in zebrafish embryos
Wnt11 is a key signalling molecule that regulates cell polarity/migration during vertebrate development and also promotes the invasive behaviour of adult cancer cells. It is therefore essential to understand the mechanisms by which Wnt11 signalling regulates cell behaviour. The process of …
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Effects of Binge Alcohol Exposure on Canonical Wnt Signaling During Fracture Repair
… in 25-40% of all orthopaedic trauma cases. The canonical Wnt pathway, through tight regulation of stabilized beta-catenin, plays an essential and pivotal role in the formation of new bone and cartilage to initiate bone repair. We sought to determine the molecular mechanisms behind …
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The Wnt Casade and Stem Cell Fate in a Basic Metazoan
The WNT signalling pathways have numerous controlling functions in embryonic development, pattern and axis formation of animals, but also play roles in sustained normal development. There are currently three known WNT signalling pathways, of which the canonical pathway is the most studied. This …
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CAMK-II: AN INTEGRAL PROTEIN IN CELL MIGRATION
… and postembryonic migratory events. The non-canonical Wnt pathway has been identified as an evolutionarily conserved signaling pathway, regulating C&E cell movements during vertebrate gastrulation. With the absence of the non-canonical Wnts (ncWnts), Wnt5 and Wnt11, during zebrafish …
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Understanding The Roles of Non-Homologous End Joining and P53 After Dna Damage
… is triggered. One of the major DNA repair pathway that mends DNA double strand breaks is non-homologous end joining (NHEJ). Abrogating the NHEJ pathway leads to an accumulation of DNA damage in the lymphoid system that triggers p53-mediated apoptosis; complete deletion of p53 in this system …
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Investigating the Non-globular Proteins of the Canonical Wnt Signalling Pathway
The canonical Wnt pathway is a vitally important signalling pathway that plays an important role in cell proliferation, differentiation and fate decisions in embryonic development and in the maintenance of adult tissues. The twelve Armadillo (ARM) repeat-containing protein beta-catenin acts as the …
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New roles for Hox and Wnt in Cell Migration
… I report new roles for established genes such as Wnt and Hox, and describe roles for several new genes in neuron migration. To study migrating neurons I use the model organism nematode worm Caenorhabditis elegans. With only 302 neurons, C. elegans is an excellent model to examine migration of …
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The role of beta-catenin in the development of fetal ovary and female germ cells
… evidence has suggested the presence of an active pathway in fetal ovary. In particular, gene screening experiments have shown that many genes are expressed specifically in ovary. Wingless related protein (WNT) proteins are one class among them. WNT proteins are known to be essential for embryo …