Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Cannabinoid receptor 1 (CB1)"”.
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Renal Cannabinoid Receptor Expression and Function: Their Role in Obesity and Diabetes
… and diabetic associated renal damage. The endocannabinoid system is an important endogenous lipid signalling system known to mediate glucose and lipid metabolism, inflammation and energy storage. Specifically, diabetes mellitus and obesity induces alterations in the expression of cannabinoid …
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Design, Synthesis And Cannabinoid Receptor Activity Of Benzofuran Ligands
The endocannabinoid system is a complex homeostatic signaling system controlled through the actions of two g-protein coupled receptors, cannabinoid receptor 1 (cb1) and cannabinoid receptor 2 (cb2). Significant neuronal expression and distribution of cb1 throughout the brain establishes its …
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… Dietary EPA and DHA are converted to omega-3 endocannabinoids (eCBs), eicosapentaenoicethanolamide (EPEA) and docosahexaenoicethanolamide (DHEA), respectively. Subsequently, omega-3 eCBs are substrates for eicosanoid-synthesizing enzymes, cyclooxygenase, lipoxygenase and cytochrome P450 (CYP450) …
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Effect Of CBD On D2 Dopamine Receptor And CB1 Cannabinoid Receptor Function And Localization
<p>Cannabidiol (CBD) is the second most abundant cannabinoid found in Cannabis sativa and its array of therapeutic effects make it a popular target of pharmacological research. Though its properties are psychoactive in nature, abuse and dependence of CBD has never been reported. Its beneficial side …
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Cytochrome P450 2J2 mediated metabolism of omega-6 and omega-3 endocannabinoids
… mediated oxygenation of omega-6 derived endocannabinoids, thereby revealing a previously unknown metabolic pathway. The endocannabinoids, anandamide (AEA) and 2-arachidonylglycerol (2-AG), are endogenous lipid mediators that are agonists of cannabinoid receptor-1 (CB1) and cannabinoid …
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An investigation into the role of cannabinoid and group 1 metabotropic glutamate receptors in the control of rhythmic locomotion in hatchling Xenopus Laevis
The group 1 metabotropic glutamate receptors (mGluR1/5) are of key interest in the synaptic plasticity that underlies learning and memory and have been implicated as a cause or target in many disease models such as Parkinson’s, Huntington’s, Alzheimer’s, depression, schizophrenia and fragile X …
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Distribution and function of TRP ion channels in primary sensory neurons
It is frequently argued that cannabinoids exert part of their analgesic and anti-inflammatory effects via activation of the cannabinoid CB1 receptor located on TRPV1-expressing primary sensory nerve fibres in peripheral tissues. However, we find no evidence of CB1 receptor immunoreactivity on nerve …