Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Canine models"”.
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Effects of survivin and survivin inhibition in canine models of lymphoma and osteosarcoma
Canine lymphoma (LSA) and osteosarcoma (OS) have high mortality rates and remain in need of more effective therapeutic approaches. Survivin, an IAP (inhibitor of apoptosis) family member protein that inhibits apoptosis and drives cell proliferation, is commonly elevated in human and canine cancer. …
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Experimental Analysis of Skull Remodeling and Change in Intracranial Volume with a soft Orthosis in Canine Models
… We attempted to reform the shape of the young canine skull with a soft orthosis that is lighter in weight and less constricting than the conventional hard orthosis. MATERIALS & METHODS: We applied a series of soft cap-like orthoses to beagle puppies in increasingly longer anteroposterior …
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Validation of tissue oxygen saturation determined by near-infrared spectroscopy in canine models of hypoxemia and hemorrhagic shock
The objective of this study was to evaluate the relationship between tissue oxygen saturation (StO2) and oxygen delivery index (DO2I). Oxygen delivery index is product of two factors arterial oxygen content (CaO2) and cardiac index (CI). In this study the relationship between DO2I and StO2 was …
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Development of translational models for intervertebral disc degeneration using a comparative approach for canine and human patients
… IVD disease (IVDD). IVDD spontaneously occurs in canine and human populations. As such, dogs can serve as highly relevant and ethical preclinical models for both human and canine IVDD. Chondrodystrophic (CD) and non-chondrodystrophic (NCD) breeds of dogs show different phenotypes of IVDD, each of …
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Fighting cancer with nanomedicine−drug-polyester nanoconjugates for targeted cancer therapy
… the growth of osteosarcoma in both murine and canine models. More importantly, the developed NCs could avidly bind to human serum albumin, a ubiquitous protein in the blood, to bypass the endothelium barrier and penetrate into tumor tissues more deeply and efficiently. When compared with …
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Carcinoma inflamatório de mama em mulheres e cadelas: análise comparativa e perspectivas terapêuticas
… and "survival". In contrast, specific terms from canine oncology, such as "canine mammary tumors", appeared isolated, highlighting the lack of interconnection between the two areas. The most common clinical manifestations in women and female dogs included edema, erythema, and the "peau d'orange" …
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The discovery and characterization of anticancer procaspase activating compounds
… and S-PAC-1 have been assessed in murine and canine models. S-PAC-1 has been found to be well-tolerated in mice, research dogs, as well as client-owned patient pet dogs with lymphoma. A continuous i.v. S-PAC-1 regimen led to a reduction or stabilization of tumor progression in some of the …
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Neuropathologic characterization of a canine model of mucopolysaccharidosis IIIB and additional studies in anti-inflammatory therapy and neuroinflammatory kinetics
… model and several naturally occurring animal models of MPS IIIB have been reported. To date, the mouse and canine models of MPS IIIB have been utilized for pathogenesis and therapeutic studies. The canine model is an ideal animal model because their larger size, easy of handling, outbred …