Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"Canine cancer"”.
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Overactive NF-KB signaling as a druggable target and evaluation of parthenolide an NF-KB inhibitor in canine cancer
… (MCT). Lymphoma is one of the most common cancer types affecting dogs and humans, and therefore, novel therapeutic approaches are always needed. For all of these cancer types, dogs and human cancers share common molecular abnormalities, consistent with a conserved pathogenesis between …
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Development of PAC-1 as a privileged agent for combination chemotherapy
Elucidation of the molecular mechanisms of cancers has enabled the development of molecularly targeted chemotherapeutics capable of exploiting cancer-specific cellular alterations. Small-molecule activation of procaspase-3 represents a particularly promising opportunity, based upon its determinant …
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Effects of survivin and survivin inhibition in canine models of lymphoma and osteosarcoma
Canine lymphoma (LSA) and osteosarcoma (OS) have high mortality rates and remain in need of more effective therapeutic approaches. Survivin, an IAP (inhibitor of apoptosis) family member protein that inhibits apoptosis and drives cell proliferation, is commonly elevated in human and canine cancer. …
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Il cane come modello animale spontaneo di patologie neoplastiche dell'uomo: ene Ataxia-Telangiectasia Mutated (ATM) Nnella predisposizione al cancro ed importanza dei riarrangimanti genici dei geni Ig/TCR per la diagnosi e prognosi delle malattie linfoproliferative
“Naturally occurring cancers in pet dogs and humans share many features, including histological appearance, tumour genetics, molecular targets, biological behaviour and response to conventional therapies. Studying dogs with cancer is likely to provide a valuable perspective that is distinct from …
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The use of massively parallel sequencing to study the virome, epigenome and genome of canine and feline cancers
… of hundreds of different types of human cancers to be defined. This knowledge gives patients two new categories of treatment options, small molecule inhibitors and targeted immunotherapy. Veterinary oncology has been slow to enter the field of genome-wide studies, largely due to costs. …
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Redox Flow Iontophoresis for Brain Cancer Therapy
… for the success of chemotherapy in brain cancer treatment is the blood brain barrier. It plays a pivotal role in protecting the central nervous system, but also significantly hinders the dose of cancer drugs which can be delivered into a tumour. One option for circumventing the blood brain …
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Investigating toll-like receptor agonists as an immunotherapeutic for metastatic osteosarcoma
… receptor agonists as an immunotherapeutic for canine osteosarcoma. From a comparative and translational perspective, the long-term goals of this research include not only the treatment of canine osteosarcoma, but also human osteosarcoma, as this disease has numerous similarities between …
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Investigating procaspase-3 as a potential therapeutic target in canine osteosarcoma
… tumor suppressive mechanism, and the ability of cancer cells to evade death is widely acknowledged as one of the hallmarks of cancer development. In tumor cell populations, disruptions in apoptosis commonly occur through modulation of key players in the apoptotic cascade. The central role of …
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ASSESSMENT OF RELEVANT MOLECULAR TARGETS WITH THERAPEUTIC SIGNIFICANCE IN CANINE NEOPLASMS.
Cancer is the leading cause of death in companion dogs. The high prevalence and impact on animal welfare, combined with biological and environmental similarities to humans, position canine cancers as valuable models for comparative oncology and translational research. Increasing canine life …