Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 496 for “"Candidate genes"”.
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Candidate Genes for Late Diabetic Complications
… factors are believed to play role in pathogenesis of diabetic complications. The aim of this study was to 1) To test the usefulness of the new WHO criteria for clinical staging of diabetes in the characterization of diabetic patients. 2) To test a putative association between late diabetic …
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Analysis of Variation In Clubfoot Candidate Genes
… and <em>CASP10</em>, two apoptotic genes, play a role in isolated clubfoot. To explore the role of apoptotic genes in clubfoot, SNPs spanning genes involved in the apoptotic pathway in the six chromosomal deletion regions, and limb patterning genes, <em>HOXD</em> and <em>HOXA</em>, …
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Prioritisation of candidate genes for psychiatric disorders
… has had limited success in identifying causal genes for complex diseases. Bipolar disorder is one such disease whose aetiology has not been elucidated despite the application of these technologies. Candidate gene prioritisation offers a solution to limit the vast amount of possible candidate …
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Epigenetic dysregulation of novel candidate genes in melanoma
… by exploiting both a systematic approach and candidate gene approach. Biomarkers TFPI2 and P4HA3 showed a high frequency and high level of methylation in melanoma cell lines. Significantly increased methylation in melanoma suggests a role for TFPI2 and P4HA3 as epigenetic biomarkers that can …
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Identifying candidate genes/loci influencing barley secondary cell wall properties
… the secondary cell wall. Therefore identifying genes which can be targeted for breeding plants with higher saccharification yields to improve their suitability as biofuel feedstocks could increase the efficiency and lower the cost of second generation production systems.<br/><br/>The work …
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Identification of QTL and candidate genes for plant density tolerance in maize
… of identifying quantitative trait loci (QTL) and candidate genes for plant density tolerance. Yield trials were grown at a high plant density of 116,140 plants ha-1 (47,000 plants per acre [ppA]), and planted in five environments over 2012 and 2013. Grain yield and a total of 33 agronomic and …
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Genetic studies of candidate genes in the glycoalkaloid biosynthetic pathway of potato
… complex than in self-pollinated crops. Both a candidate gene approach and a whole genome SNP genotyping analysis were used to assess allelic variation and to identify loci associated with biosynthesis and accumulation of steroidal glycoalkaloids (SGAs). SGAs are secondary metabolites produced …
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Fzd6, Matn2 and Slc25A32, Possible Candidate Genes In Nonsyndromic Cleft Lip and Palate
… region contained three biologically relevant candidate genes: <em>Frizzled-6 (FZD6) </em>(LOD = 2.8), <em>Matrilin-2 (MATN2)</em> (LOD = 2.3), and <em>Solute Carrier Family 25, Member 32</em> <em>(SLC26A32</em>) (LOD = 1.6). Sequencing of the coding regions and the 5’ and 3’ UTRs of these …
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VALIDATION OF CANDIDATE GENES IN RESPONSE TO VERSICAN MANIPULATION IN DEVELOPING SYNOVIAL JOINTS
… focusing on hyaluronan and Wnt pathway genes as they pertain to the misexpression of versican. RT-PCR and real-time PCR were used in this study to validate expression of the genes chosen. Through the use of these techniques the degree of expression has been quantified and compared to the …
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Mutation analysis of important retinal candidate genes: progression from research to diagnostic service
… currently involves mutation screening of retinal candidate genes, with the goal of identifying the causative genetic mutation in each of the families registered in the database, in order to facilitate future therapeutic intervention. The purpose of this study was to determine the distribution and …
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Exploring candidate genes and rhizosphere microbiome in relation to iron cycling in Andean potatoes
… These approaches require the identification of candidate genes to uptake, transport and store Fe in potato tubers. We employed multiple approaches including SNP genotyping, QTL analysis, identifying genes orthologous to Arabidopsis ferrome, yeast complementation assay and genetic transformation …
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ZEBRAFISH (DANIO RERIO) AS A MODEL SYSTEM FOR THE FUNCTIONALVALIDATION OF CANDIDATE GENES FOR HUMAN DISEASES
… possible due to the very high conservation of genes and of organs and systems which are fully functional within the very first days of embryonic development. The easy and efficient genetic manipulation, the large number of offspring, and the rapid and external development of the embryos make …
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Identification of quantitative trait loci, candidate genes and diagnostic markers for Hessian fly resistance in wheat
… management. Although over 50 HF resistance (H) genes and quantitative trait loci (QTL) have been reported, only a few of them have been deployed in limited areas due to their loss of effectiveness against predominant HF biotypes, and lack of diagnostic markers for breeding selection. To discover …
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Towards candidate genes for schizophrenia - the APO/SUS-APO/UNSUS rat model and human association studies
Contains fulltext : 83777.pdf (Publisher’s version ) (Open Access)
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Candidate genes other than the CFTR gene as possible modifiers of pulmonary disease severity in cystic fibrosis
… in pulmonary disease severity and progression. Genes involved in modulating the inflammatory response and genes increasing susceptibility to infection are proposed as modifiers of pulmonary disease severity. Polymorphisms selected for based on evidence that they affect the function of the gene …
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SNP ANALYSIS FOR DROUGHT-RELATED CANDIDATE GENES IN A GERMPLASM COLLECTION AND A TILLING POPULATION OF ITALIAN RICE
… genetic variability in drought-related candidate genes was then explored in a TILLING population developed in the Italian rice variety Volano. The Volano TILLING platform was validated through the screening of three relevant target genes. A mutation density of 1/374 kb was estimated, …
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The use of whole exome sequencing data to identify candidate genes involved in cancer and benign tumour predisposition
… into functionally related regions, including genes, gene clusters, and pathways, allows for the detection of biological processes that, when interrupted, may impact disease risk. In silico functional studies can also be utilised to further understand how variants disrupt biological processes …
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Identifying genetic variation in candidate genes for heat stress and association thereof with growth performance in dusky kob (Argyrosomus japonicus)
… of heat stress. Furthermore, since many genes involved in regulating heat stress are conserved, there is concern about whether the rate of climate change may exceed that of species adaptation to it. Therefore, the aims of this study were as follows: firstly, to briefly assess and compare …
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