Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 236 for “"Candidate gene"”.
-
Candidate gene scoring to predict broad adolescent psychopathology
This Thesis was approved for publication on 2018-04-23 at 10:50.
-
A candidate gene analysis of arrhythmogenic right ventricular cardiomyopathy (ARVC)
… loci have been linked to ARVC and six genes have been identified. In 2004 Asano and colleagues reported a mouse model of ARVC that established LAMRI and CBX5 as candidate genes for the human form of ARVC.
-
Fine Mapping and Candidate Gene Discovery at the Rsv3 Locus
… of single dominant, strain specific resistance genes, referred to as Rsv genes. Rsv1 is the most widely used form of SMV resistance with nine different alleles conferring resistance only to the lower numbered less virulent strains, G1 to G3. Rsv3 gives resistance to higher numbered more virulent …
-
Genetics of Eating Disorders: a candidate gene and a genome-wide association approach
… of the phenotypic variance is accounted for by genetic factors. The presumed genetic architecture of eating disorders constitutes multiple genetic variants, each with a small effect size. This thesis aimed to replicate findings from the most extensive genetic studies of eating disorders done …
-
Sequence Analysis of PMEL17 as Candidate Gene for Causing Rat-Tail Syndrome in Cattle
Congenital hypotrichosis in cattle is commonly referred to as "rat-tail" syndrome and is characterized by a dilution of black coat color and morphological changes to the hair shaft and tail switch. Two loci are involved in the inheritance of the rat-tail phenotype, the "extension locus" (MC1R) …
-
Functional genomics in the stroke-prone spontaneously hypertensive rat: genome wide and candidate gene analysis
… genomic strategies investigated chromosome 2 candidate hypertension genes, focussing on the oxidative-stress defence gene, glutathione s-transferse mu type 1 (Gstm1). Ingenuity pathway analysis of renal microarrays in 5 and 16-week SHRSP, normotensive Wistar Kyoto (WKY) and chromosome 2 …
-
Genetic diversity and candidate gene association analysis for growth in the South African Yellowtail (Seriola lalandi)
… to tank culture, Yellowtail is an excellent candidate for aquaculture. South Africa still relies on wild individuals as broodstock population to produce offspring through mass spawning to produce individuals for the market. Conventional selective breeding strategies are not as effective as …
-
Generation of a CRISPR-Cas9 mediated knock-in reporter for the GRIA3 candidate gene for schizophrenia
… of Schizophrenia (SZ) and implicates genes in this pathway as potential candidates for the condition. A study on α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor genes found strong evidence of association between the Glutamate Ionotropic Receptor AMPA Type Subunit 3 …
-
Candidate Gene Expression and SNP Analyses of Toxin-Induced Dilated Cardiomyopathy in the Turkey(Meleagris gallopavo)
… often occurs without a consensus cause. Though genetic and other studies of IDCM are extensive, the specific etiology of toxin-induced is still unknown. Here, our objective was to compare the level of mRNA expression of two candidate genes including troponin T (cTnT) and phospholamban (PLN) …
-
A candidate gene based investigation of aberrant DNA methylation in the pathogenesis of primary cutaneous T-cell lymphoma
… T-cell lymphoma (CTCL) is a clinically heterogeneous malignancy of mature skin-homing T-cells. Mycosis fungoides (MF) is an indo¬lent subtype of CTCL whilst Sezary syndrome (SS) is an aggressive leukaemic variant characterised by the presence of malignant Sezary cells in the periph¬eral blood. …
-
Characterization of PRD-1 Mutation in Neurospora crassa
… such as FRQ/WCC and FLO. The frequency (frq) gene and white collar genes (WC-1 and WC-2) are the most important components of the FRQ/WCC oscillator and prd-1 and prd-2 genes could be important components of the FLO. This project aims to characterize the prd-1 mutation. This involved mapping …
-
THE GENETIC BASIS OF INTERSPECIFIC FEMALE PREFERENCE IN DROSOPHILA SIMULANS
Behavioral differences between species have a genetic basis and contribute to species isolation. Genomic regions have been identified that influence female rejection of heterospecific males on the right arm of the third chromosome in Drosophila, however, no individual loci have been identified. …
-
Elucidating the molecular basis of a novel autosomal dominant fibrotic syndrome
… tendons and viscera, with variable penetrance. A candidate gene approach was adopted to investigate the molecular basis of this disease.
-
GENETIC VARIANTS OF ADIPOQ AND ASSOCIATION WITH PLASMA ADIPONECTIN LEVELS, TYPE 2 DIABETES, GLUCOSE HOMEOSTASIS AND ADIPOSITY
… a combination of environmental, lifestyle, and genetic factors. This study seeks to explore the genetic component of diabetes risk through evaluation of a candidate gene, ADIPOQ, encoding the adiponectin protein. Adiponectin is an adipocytokine that has been implicated in a wide variety of …
-
Understanding the classical maize floral development mutant, Polytypic ear1
… or branch-like protrusions. While the causative gene is unknown, RNA-seq provided direction for candidate gene analysis. Our top candidate gene, ethylene response sensor1 (ers1), encodes a putative ethylene receptor that shows allele-specific expression in Pt1. Ethylene receptors negatively …
-
Genetics of Obesity and Diabetes in the IRAS Family Study
… concern. Research involving the discovery of genes contributing to these diseases is great public health importance. Identification of a gene and/or genes that contribute to the phenotypic variance of obesity and/or glucose homeostasis traits measured in this study could lead to better methods …
-
Extracellular matrix gene sequence variant analyses and Achilles tendinopathy
… aim of this thesis was to identify additional genetic elements predisposing individuals to risk of AT using a candidate gene, case-control genetic association approach, and to propose the biological mechanisms underlying this genetic risk. Candidate genes (COMP, THBS2, COL27A1, TNC, COL3A1, …
Page 1 of 12