Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"Candidate Loci"”.
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A landscape genomic approach to investigating growth performance in South African Bonsmara cattle
… in RStudio. The output results consisted of candidate loci that the LEA identified to be associated with the environmental variables included in the weather datasets. The Fst values for each candidate loci list (three lists in total; one per province) were calculated and the 20 SNPs (20 SNPs …
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Gene polymorphisms in SLE
… with over 28 confirmed disease susceptibility loci mapped and a number of candidate genes identified. During this thesis I fine mapped IL18 as it had previously been reported to be associated with SLE, SNP rs360719. After fine mapping and subphenotype analysis in UK and African American …
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Genetic Characterisation of Neurodegenerative disorders
… in risk for disease in idiopathic PD. Twenty six candidate loci have been found in this whole-genome association study and they provide the basis for our investigation of disease causing genetic variants in idiopathic PD.
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1,000 ancient genomes uncover 10,000 years of natural selection in Europe
… Age, and Historical periods, and to identify 25 loci with evidence of rapid changes in allele frequency during these periods. All 10 candidate loci in the Historical period were detected in previous scans, with many associated with vitamin D metabolism. Strikingly, 17 out of 19 of the candidates …
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Genetic and functional investigation of sequence variation associated with the related phenotypes: birth weight, obesity, and type 2 diabetes (T2D)
… in adulthood, with several T2D susceptibility loci reported to be associated with fetal birth weight, including the leptin receptor gene (LEPR). Aims: To ascertain if maternal candidate loci contribute to fetal birth weight variation in a Gujarati South Asian immigrant population in North …
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Identification and Characterisation of the Barley Row-Type Gene <i>VRS3 </i>
… with specific genes identified at three loci, <i>VRS1</i>, <i>VRS4</i> and <i>INT-C</i>. Advancements in the understanding of the genetic control underpinning barley row-type enables the identification of potential mechanisms for improving yield and yield architecture within the cereals. …
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Neural Correlates of Item and Item-Context Memory Encoding
… 'subsequent memory effects' -- can be considered candidate loci of neurocognitive operations supporting successful episodic encoding. The aim of the present work was to disambiguate the neural correlates of item and item-context (source) memory encoding, and investigate age-related differences in …
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Mining Genomic Variants And Causal Pathways Linking Hdl And Triglycerides To Coronary Disease
… we functionally examined one of the first novel loci from genome-wide association studies (GWAS) for HDL-C, GALNT2. Through discovery of humans with genetic GALNT2 LOF and additional studies in rodents and nonhuman primates, we showed that GALNT2 LOF lowers HDL-C across mammals. We also identify …
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Investigating the role of demography and selection in genome scale patterns of common and rare variant diversity in humans
… to pinpoint disease and metabolism-related candidate loci. A subset of the WGS dataset, designed to maximise coverage of diverse ethnic groups (n = 447), was screened for variants occurring exclusively in two individuals in a heterozygous state (f2 variants). It was shown that f2 sharing …
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Molecular phylogenetics, systematics, reproductive safeguarding and chromosome evolution of the genus Lachenalia (Asparagaceae: Scilloideae)
… phylogenetic tree using Sanger sequencing of candidate loci and/or morphological characters have been largely unsuccessful. A new phylogenetic hypothesis for Lachenalia is presented, using multi-locus sequence data sampled from living material of 132 taxa via maximum likelihood and …
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Subclinical Phenotypes and Genotypes in Parents of Children with Non-Syndromic Cleft of Lip and/or Palate
… phenotype and their association with specific candidate genes.<b><br/></b><b><br/></b><b>Methods</b>: Using a case-control study design with 156 participants of Celtic background (81 parents, 75 controls), 2D photographs of the face and lower lip (Nikon D70, www.europe-nikon.com), an ultrasound …
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Methods for Determining the Genetic Causes of Rare Diseases
… of the two models, allowing prioritisation of candidate loci for involvement in disease with respect to a heterogeneous collection of disease phenotypes. SimReg includes a sophisticated treatment of HPO-coded phenotypic data but dichotomises the genetic data at a locus. Therefore, we developed …
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Optimizing nuclear transgene expression and genome editing for high-value compound production in the green microalga Chlamydomonas reinhardtii
… regions of recently discovered polycistronic loci were tested for biotechnological application of nuclear gene expression in C. reinhardtii. Simultaneous expression of terpene synthases was demonstrated with the potent selection marker aphVIII. By applying this transgene structure, terpenoid …
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From Genes to Traits and Ecosystems: Evolutionary Ecology of <i>Sphagnum</i> (Peat Moss)
… in response to environmental stress and provide candidate loci that might underlie adaptation to the harsh conditions of boreal peatlands.</p></p>
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Patterns of association in a co-introduced insect herbivore and parasitoid wasp
… the introduced range of the U.S. Thirty-four candidate loci were identified, 12 of which were ultimately chosen for detailed screening. Seven of the 12 loci were polymorphic, but only 5 of the 7 were successfully amplified across samples and ranges. Of these 5 polymorphic loci, there were 3 - …