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Showing 1 to 3 of 3 for “"Candid#1"”.
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Mechanisms of attenuation of the live Junin virus vaccine strain, Candid #1
… for which a vaccine is currently in use. The Candidate #1 (Candid #1) vaccine strain, which was obtained from the 44th mouse brain passage of the parental XJ strain, has significantly reduced the incidence of disease in endemic areas. However, the mechanisms of attenuation and protection …
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Genetic Determinants of Junin Virus Attenuation
… regions of Argentina. The live-attenuated Candid #1 strain of JUNV is currently used to vaccinate human population at risk. However, the mechanism of attenuation of this strain is still largely unknown. Therefore, the identification and functional characterization of viral genetic factors …
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The introduction of incompatibility between Junin virus Z protein and other viral proteins results in impaired replication and attenuation
… of the disease. This live-attenuated vaccine, Candid#1 (Can), contained many amino acid divergences from wild type JUNV that may contribute to the attenuation profile. Preliminary experiments identified a natural incompatibility between the Can Z protein and wild type Romero (Rom) strain LP …