Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 2334 for “"Cancers"”.
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Signaling crosstalk in cancers
… pathways was investigated in two common human cancers. \r\n Pancreatic cancer has a well known spectrum of genetic alterations, among which KRAS mutation is the most prominent component with a detection frequency as high as 90%. Hedgehog signaling pathway is involved in developmental process …
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Novel immunotherapy for paediatric cancers
Chimeric antigen receptors (CAR) are synthetic receptors that redirect T lymphocytes to specific tumour antigens. CART cells targeting CD19 (CAR19) have demonstrated remarkable efficacy against B cell malignancies in clinic. Currently used methods of CAR gene transfer to T cells based on viral …
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Modelling timing in blood cancers
Dysregulation of biological processes in normal cells can lead to the abnormal growth of tumours. Oncogenesis requires the acquisition of advantageous mutations to expand in a fluctuating environment. Cancer cells gain these genetic and epigenetic alterations at different timing in their …
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Identification of Image-based Markers for Oral Pre-cancers and Cancers using in-vivo Multimodal Imaging
… benign tissue from treatable high-risk precancers and cancers for biopsy guidance. Nonlinear optical microscopy (NLOM) has shown potential to identify optical signatures associated with microstructural and biochemical alterations in cancer, providing in-vivo three-dimensional imaging with …
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Mitochondrial Metabolism of Human Kidney Cancers
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
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Immunotherapy of Folate Receptor Expressing Cancers
The folate receptor (FR) is a GPI anchored cell surface glycoprotein that functions to facilitate folic acid uptake and mediate signal transduction. With the introduction of multiple folate-targeted drugs into the clinic, the question has arisen regarding how frequently a patient can be dosed with …
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Second cancers following treatment for retinoblastoma
… have elevated risks of developing additional cancers, mostly bone and soft tissue sarcomas and melanoma. Despite advances in understanding of second cancer risks following treatment for retinoblastoma, key research questions remained including 1) risks of common adult onset cancers, some of …
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Axl RTK and microRNAs in urogenital cancers
… been shown to be a target of miR-34a in solid cancers, and high Axl expression correlates with worsened prognosis in RCC. We showed that both miR-34a and miR-34c are direct regulators of Axl in vitro, however miR-34a expression is increased in ccRCC and does not correlate with Axl mRNA or …
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Exploring the tumor microenvironment of immunogenic cancers
Contains fulltext : 302594.pdf (Publisher’s version ) (Open Access)
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Signatures of chromosomal instability in human cancers
… as to the frequency of CIN across human cancers, the number of detectable types in a genome, and the possibility of their co-occurrence, remain only partially answered. In this thesis, I present a comprehensive compendium of CIN in cancer using genomic profiling of over 10,000 patient …
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Circulating Tumour DNA in Localised Urological Cancers
… informative biomarkers in localised urological cancers. At present, no method can accurately distinguish between indolent and aggressive prostate cancers, and men often require repeated biopsies. Patients with muscle invasive bladder cancer undergo neo-adjuvant chemotherapy (NAC) to improve …
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Characterising pathways driving aggressive biology and chemoresistance in triple negative breast cancers biology and chemoresistance in triple negative breast cancers
This body of work served to investigate the mechanisms driving chemoresistance in a series of in vitro TNBC cell line models. Molecular characterisation and comparison of drug resistant models allowed for the identification of promising druggable targets, whose efficacy in restoring …
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The Role of METTL21A in Kras-driven Cancers
<h2>Abstract</h2> <p>More than 100 lysine methyltransferases (KMTs) were predicted to be present in the human proteome, and many were implicated in cancer etiology. However, the catalytic activity and substrate specificity for many of these enzymes remain unknown. Our work aimed to explore the role …
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Free radical mediated oxidative stress in plant cancers
This project provides for the first time an in depth examination of oxidative stress and antioxidant protection in plant tissue cultures undergoing various stages of ageing and neoplastic progression towards a cancerous state. Two experimental systems were investigated: (1) <i>Beta Vulgaris</i> …
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NF-YA ISOFORMS ROLES IN CLAUDIN LOW CANCERS
… breast, colon, thyroid, prostate, and leukemia cancers. NF-YA is present in two major isoforms called NF-YAl (long), and NF-YAs (short), which alternative splice exon 3. NF-YAl/NF-YAs ratio changes in different tissues, cell lines and differentiational stages. A robust increase in mRNA levels of …
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Regulation Mechanisms of Peptide Hormones in Neuroendocrine Cancers
In the work described in this thesis, analytical methods for the detection and quantification of peptide hormones featuring on-line analyte concentration, post-separation tagging and HPLC-fluorescence detection were presented. These methods were used to detect and quantify calcitonin (CT) and its …
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Regulation Mechanisms of Peptide Hormones in Neuroendocrine Cancers
In the work described in this thesis, analytical methods for the detection and quantification of peptide hormones featuring on-line analyte concentration, post-separation tagging and HPLC-fluorescence detection were presented. These methods were used to detect and quantify calcitonin (CT) and its …
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The Intra-Tumour Heterogeneity Landscape of Human Cancers
… I describe the findings. I find that nearly all cancers, for which there is sufficient power, contain at least one subclone (96.7% of 1,801 primary tumours). The subclones contain driver mutations that are under positive selection, and known cancer genes contain subclonal driver mutations in low …
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Characterization of ADAM10 in cervical and oesophageal cancers
… with the proliferation and metastasis of cancers including, breast, lung, and colon. While ADAM10 has been investigated in these cancers, very little is known of its role in cervical and oesophageal cancer. The aim of this study was to investigate the endogenous expression of ADAM10 in …
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