Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 205 for “"Cancer--Research"”.
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The ideology of cancer research.
Massachusetts Institute of Technology. Dept. of Urban Studies and Planning. Thesis. 1972. B.S.
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Unnatural glycopeptides with application on cancer research
… with relevant implications to fight against cancer: mucins, such as mucin-1 (MUC1), and antifreeze glycoproteins. Concerning the first mentioned class, mucins are a family of O-glycoproteins with high molecular weight that serve as cell-surface receptors and sensors. Notably, aberration in …
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Motivating Subjects: Data Sharing in Cancer Research
… lens of a case study: scientific data sharing in cancer research. The research begins with the premise that motivation and emotion are key elements of what it means to be human, and consequently, are important variables in how individuals make decisions and take action. At the same time, …
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OPTICAL COHERENCE TOMOGRAPHY FOR NEUROSURGEY AND CANCER RESEARCH
… and novel imaging algorithms for monitoring anti-cancer therapy have been pursued in this work. A forward-imaging needle-type OCT probe was developed which can fit into minimally invasive tools (I.D. ~ 1mm), detect the at-risk blood vessels, and identify tissue micro-landmarks. This promising …
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Simplifying Science: Scientific Uncertainty in News Coverage of Cancer Research
News coverage of scientific research is routinely streamlined. In other words, the research is stripped of caveats, limitations, and other indicators of scientific uncertainty. But whether streamlining affects audience perception is unknown. It has been suggested that streamlining may (a) influence …
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Mathematical Imaging Tools in Cancer Research - From Mitosis Analysis to Sparse Regularisation
… deals with customised image analysis tools in cancer research. In the field of biomedical sciences, mathematical imaging has become crucial in order to account for advancements in technical equipment and data storage by sound mathematical methods that can process and analyse imaging data in an …
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Essays on Mathematical Modeling and Empirical Investigations of Organizational Learning in Cancer Research
… reignitions since the initiation of the "War on Cancer" more than five decades ago, the recent reignition of "Moonshot to Cure Cancer" points to the systemic persistence of cancer as a major cause of loss of life and livelihood. Literature points to the diminishing returns of cancer research …
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Single-Cell Approaches in Hematologic Cancer Research: Deciphering the lmpact of Splicing Factor Mutations
La presente tesis doctoral emplea tecnologías de secuenciación de célula única para profundizar en la biología del cáncer. En primer lugar, se analiza el impacto de las mutaciones en los factores de splicing SF3B1 y U1 en muestras de pacientes de leucemia linfática crónica. En los tumores …
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Data-driven modelling and optimised reverse engineering of complex dynamical systems in cancer research
Biological systems typically generate complex data that encapsulate the dynamics of interactions among measurables over time. To support the formation of insights into time series data from a biological system, there is a requirement to develop new methods that can analyse and translate such …
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Expression and Purification of Unlabelled and Isotopically Labelled Human Fibroblast Growth Factor-1 and its Receptor Relevance in Cancer Research
… vessels and cell proliferation in some types of cancer. The biological activities of FGFs are primarily mediated via interactions with fibroblast growth factor receptors (FGFR) and are a potent target in cancer. In this study, we report an efficient affinity column purification of hFGF-1 and the …
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Statistical Methods For Two Problems In Cancer Research: Analysis of Rna-Seq Data From Archival Samples and Characterization of Onset of Multiple Primary Cancers
… important topics in translational and clinical cancer research.</p> <p>The first topic was motivated by the challenge of applying transcriptome sequencing (RNA-seq) to formalin-fixation and paraffin-embedding (FFPE) tumor samples for reliable diagnostic development. We designed a biospecimen …
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Detection and enrichment of cytochrome P450s using bespoke affinity chromatography and proteomic techniques. Development of chemical immobilisation and novel affinity chromatography methods, with subsequent proteomic analysis, for the characterisation of cytochrome P450s important in cancer research.
… and excretion. P450s are also implicated in cancer as they can act to ¿negatively¿ de-activate or ¿positively¿ activate cancer therapeutics. Identifying specific P450s that are highly up-regulated at the tumour site could be used to predict drug response and formulate targeted cancer therapy …
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OPTIMISATION AND THERAPEUTIC-TARGET-DISCOVERY ORIENTED ANALYSIS OF CRISPR-CAS9 SCREENS
… of CRISPR-Cas9 technology has revolutionized cancer research by enabling targeted genome modifications in tumour cells, offering insights into cancer biology and potential treatment targets. My PhD research focuses on developing tailored tools and pipelines to enhance the analysis of …
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Label-Free Microfluidic Devices for Single-Cell Analysis and Liquid Biopsies
Mortality due to cancer is a global health issue that can be improved through further development of diagnostic and prognostic tools. Recent advancements in technologies aiding cancer research have made significant strides, however a demand for a non-invasive clinically relevant point-of-care tools …
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Design and Evaluation of Peptide Lipid-Associated Nucleic Acids (PLANAs) for siRNA and CRISPR/Cas9 Delivery and Protein Silencing
<p>Breast cancer affects 1 in 8 women in the United States. The American Cancer Society has estimated that in 2020 about 276,480 new cases of invasive breast cancer will be diagnosed in women. Cancer research has taken a turn in the last several decades to focus on new approaches to combat the …
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Accuracy of volumetric vs. weight measurement in nutrient analysis for research
… vs. weight measurement in nutrient analysis for research Emma K. Partridge, Student, University of Washington Jeannette M. Schenk, PHD, MS, RD, Fred Hutchinson Cancer Research Center Kara Breymeyer, MPH, RD, Fred Hutchinson Cancer Research Center Marian L. Neuhouser, PhD, RD, Fred Hutchinson …
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The Role of Protocadherin 7 in Lung Adenocarcinoma
Lung cancer is the leading cause of cancer-associated deaths worldwide. Despite recent advances in the development of targeted therapies for lung cancer, most patients develop resistance to these targeted therapies. Our lab has uncovered a key oncogenic role for Protocadherin 7 (PCDH7) in non-small …
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