Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 122 for “"Cancer therapies"”.
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Defining Determinants of Primary Drug Resistance in Precision Cancer Therapies
… biological processes, including diseases like cancer. Through our accumulated understanding of cancer genomics, targeted therapies, which inhibit the specific driver oncogenes and pathophysiological processes that underlie cancer progression, have been developed. However, in modern precision …
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Drug-encapsulating EGF-sensitive liposomes for EGF-overexpressing cancer therapies
… of epidermal growth factor (EGF)-overexpressing cancers due to the potential advantages, relative to current clinical therapies (generally limited to surgery, radiation therapy, traditional chemotherapy, and EGF receptor inhibitors (EGFRIs)), of using such 'smart' targeted drug delivery systems. …
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Inhibition of the endosomal recycling pathway to overcome resistance to cancer therapies
Cancer is a major public health threat with incidence and mortality rates continuing to rise every year. Breast and prostate cancer are the most diagnosed cancers in women and men, respectively. Both cancers account for roughly 30% of all cancers diagnosed in each sex. Despite the continuous …
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Techniques for comparing efficacy and cost-effectiveness of cancer therapies, and improved inference tools
… both efficacy and cost-effectiveness of cancer therapies. Chapter 5 focuses on the second topic. It proposes a new estimator for the number of binomial experiments when the success probability is unknown. Chapter 2 of my thesis establishes an overall ranking of efficacy of possible …
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Targeting histone deacetylase (HDACs) enzymes with novel bisnaphthalimidopropyl derivatives (BNIPs) as alternative breast cancer therapies.
Breast cancer is the most commonly occurring cancer in women, with incidence rates approaching 1.38 million cases per year worldwide. Over the last few decades, there have been numerous attempts to develop, synthesise and advance into the clinic novel and selective breast cancer therapies. Research …
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The physico-chemical and biological analysis of microbial biosurfactants (BSs) for applications towards cancer therapies, wound healing dressings and drug delivery
… of therapeutic applications including possible cancer therapy, chronic wound healing and nanoparticulate drug delivery systems. However, due to their individual complexities, there is limited physico-chemical analysis relevant to their drug delivery applications. The aims of this research are …
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Evaluation of nanoparticles-based thermotherapy for cancer
… be used to generate heat for the treatment of cancer. With suitable coating, these nanoparticles are biocompatible, stable in solution, and absorbed by tumor cells in good contrast. The mechanism of heating is mainly due to Neel relaxation process and a quantity called specific loss power (SLP) …
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Structure-guided Cancer Vaccines based on Glycopeptides Supported on Diverse Nanoparticles
Cancer is a worldwide problem and various cancer therapies are emerging as potential solutions. Among these cancer therapies, a very attractive strategy is that of therapeutic cancer vaccines, which can use tumor-associated peptide fragments that can induce an immune response. In this thesis, we …
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Examining metabolic vulnerabilities for cancer therapy
Metabolic reprogramming is essential for cancer cells to balance energetics, maintain redox homeostasis, and synthesize biosynthetic precursors. Many chemotherapeutics that target metabolism are essential components of standard cancer treatment regimens, arguing that there is a therapeutic window …
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Decoding The Tumor and Immune Microenvironment In Pdac and Breast Cancer By Single Cell Sequencing.
… gene changes for the purpose of immune-related cancer therapies. First we have characterized the T cell populations of the normal and malignant human pancreas. Furthermore, we utilized single cell TCR sequencing to track transcriptional states of T cell clones from human PDACs into a T cell …
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Mechanisms and consequences of resistance to PRMT5 Inhibition
Drug resistance to cancer therapies poses a major clinical challenge and is a key obstacle to successful cancer treatment. Understanding how resistance develops and whether resistance brings new vulnerabilities, or collateral sensitivities, to secondary therapies is essential to combating drug …
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Detection of AR gene rearrangements and regulation of AR variant-driven prostate cancer models
Prostate cancer is one of the leading causes of death for men in the United States. The androgen receptor (AR) plays a central role in normal prostate development and homeostasis, but prostate cancer cells are also dependent on AR signaling for growth and survival. AR is the target for most …
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Inferring context-specific essentiality networks using large-scale CRISPR-KO screens
… offer insights into vulnerabilities of different cancer types and provide promising targets for personalized cancer therapies. However, the challenge is to systematically identify and define those context-essential genes and to understand how cellular phenotype and interaction networks are altered …
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Network analyses for functional genomic screens in cancer
… Aberrant growth factor pathway activity drives cancer pathology and is the target of molecular cancer therapies. Specifically, the epidermal growth factor receptor (EFGR) pathway and its ligand, transforming growth factor alpha (TGF[alpha]) are clinically relevant to gastric cancer. We use an …
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Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis
… prompting research into anti-angiogenesis based cancer therapies. CD39/NTPDasel is an ectoenzyme expressed by vascular endothelium that hydrolyses extracellular nucleoside di- and triphosphates to the monophosphate derivatives. As such, this enzyme has a role in modulating endothelial responses …
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Exploring cancer metabolism through isotopic tracing and metabolic flux analysis
Cancer is the second leading cause of death following heart diseases in the U.S. During the past two decades, cancer metabolism has emerged as an indispensable part of contemporary cancer research. Various types of metabolic alterations in cancer cells have been documented, prompting extensive …
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The role of the PD-1 pathway in the tumor microenvironment
… system has proven valuable in the fight against cancer. Therapies that unleash a T cell response against tumors have led to durable remissions in multiple cancers. Specifically, antibodies blocking the programmed death (PD)-1 pathway have been approved for the treatment of metastatic melanoma, …
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