Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 129 for “"Cancer stem cells"”.
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Cellular Mechanisms of Cancer Stem Cells
The file named "bhagwandinvikash.pdf" is the primary dissertation file. To access the supplemental video, click on the file named "3D_BLI_of_Pancreatic_Tumor.mpg".
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Molecular Characterization of Glioblastoma Cancer Stem Cells
… relapse of GBM is believed to be sustained by cancer stem-like cell populations that are able to initiate and maintain tumors. Although CSCs represent only a small fraction of cells within a tumor, their high tumor-initiating capacity and therapeutic resistance is believed to drive …
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Targeting survival pathways in cancer stem cells
The discovery of tumor-initiating cells endowed with stem-like features, and therefore referred to as cancer stem cells (CSCs), has added a further level of complexity to the pathobiology of neoplastic diseases. This uncommon cellular subpopulation has been connected with tumor initiation, …
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The role of cancer stem cells in osteosarcoma
… understood, however, recent studies suggest OS cancers contain a small population of cancer stem cells (CSC) which initiate tumour growth. The cancer stem cell hypothesis describes cancers as a hierarchical population of heterogeneous cells. It has been proposed that CSC are at the base of this …
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Role of cancer stem cells in breast and prostate cancer
Cancer stem cells (CSC) are thought to be responsible for the initiation, propagation and tumour re-occurrence. CSC have been identified in most solid and haematological cancers and account for ~1% of the total cell population. Culturing cancer cell lines in monolayers enriches for the most …
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Role Of d16HER2 Splice Variant In Breast Cancer Stem Cells
… is overexpressed in about 20% of human breast cancers (BCs). Evidence suggests that the co-existence of the full-length/wild-type HER2 oncoprotein (WTHER2) with its altered isoforms increases the heterogeneity of HER2 overexpressing (HER2+) disease thus affecting its biology and treatment …
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Microenvironmental Modulation of Breast Cancer Stem Cells Through Biological Matrix
<p> Breast cancer is the second leading cause of death among American women and almost 12.5% of the women are diagnosed with invasive breast cancer in the course of her lifetime. Recent advancement in breast cancer research has identified a rare, highly tumorigenic population of cells within tumors …
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RADIOSENSITIZING EFFECTS OF THROMBIN PEPTIDE TP508 ON MEDULLOBLASTOMA CANCER STEM CELLS
Brain cancer is the second leading cause of cancer-related deaths in children in the United States, with medulloblastoma leading all pediatric cases. With intensive treatments, including surgery, radiation, and/or chemotherapy, the average 5-year survival rate is approximately 60-80 percent. …
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Identification and Characterization of Her2/Neu-Transformed Breast Cancer Stem Cells
… variety of human solid tumors, including breast cancer, are considered to embrace a hierarchical organization in which only infrequent tumor-initiating cancer stem cells are truly responsible for tumor formation rather than the non-tumorigenic majority. However, these cancer stem cells remain …
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Role of Polyphenolic Compounds in Chemoprevention of Breast Cancer Stem Cells
… key signaling pathways involved in breast cancer prevention. One noteworthy product, the Polyphenol-Enriched Blueberry Preparation (PEBP), produced by the fermentation of blueberries by the bacterium Rouxiella badensis subsp. acadiensis has demonstrated various beneficial properties, …
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Characterization of Genes Specifically Expressed in Embryonic and Cancer Stem Cells
ES cells are derived from the ICM of blastocyst and have ability of self-renewal, unlimited proliferation and pluripotency that differentiate into cells of all three germ layers. The stem cell genes such as Pou5F1 (Oct4, Oct3/4), Sox2, Nanog, LIN28, KLF4, Myc (c-Myc) act alone and interact with …
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Prostate Cancer Stem Cells: Drug to lerance, Experimental Reconstitution and Castration Resistance
<p>Prostate cancer (PCa) is one of the leading malignancies affecting men in the Western world. Although tremendous effort has been made towards understanding PCa development and developing clinical treatments in the past decades, the exact mechanisms of PCa are still not clearly understood. …
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The emerging roles of BAP1 and cancer stem cells in Malignant Mesothelioma
… (MMe) is an aggressive asbestos-related cancer with a poor prognosis and the standard treatments are not effective. The lack of successful therapies is due to several factors, including the poor knowledge of mesothelioma biology. In this thesis, several biological aspects have been …
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CROSSTALK BETWEEN TUMOUR VASCULATURE AND OVARIAN CANCER STEM CELLS: THE ROLE OF L1CAM.
Ovarian cancer is the most lethal gynaecologic tumour, mainly due to relapse and chemoresistance, two events fuelled by ovarian cancer stem cells (OCSC). The tumour microenvironment (TME) is thought to act as a niche for OCSC, preserving stem cells properties and sustaining tumour recurrence. The …
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Lmw-E Mediates Mammary Tumorigenesis By Deregulating Acinar Morphogenesis & Generating Cancer Stem Cells
… of cyclin E by elastase in</p> <p>breast cancer generates two low molecular weight (LMW) isoforms that exhibit both</p> <p>enhanced kinase activity and resistance to p21 and p27 inhibition compared to fulllength cyclin E. Clinically, approximately 27% of breast cancer patients …
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Metastatic cell responses to anticancer therapy: The possible role of cancer stem cells
Metastasis is a multistep process, by which cancer cells dissociate from the initial site and travel to form new secondary tumours at distant sites. This process has been reported to require epithelial-mesenchymal transition (EMT), by which the epithelial cancer cells convert to a mesenchymal form, …
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Exploring Cancer Stem Cells (CSCs) pathways to design novel therapies for glioblastoma treatment
… in their tumor-forming potential: there are both cells with a limited lifespan that are destined to abortive differentiation and will eventually stop dividing, and a small subset of self-renewing tumoral cells capable of initiating and maintaining tumor growth. These cells are called Glioblastoma …
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PLGA-DS reverses chemoresistance in malignant mesothelioma by targeting hypoxia induced cancer stem cells
… (NF-κB), which is further upregulated in cancer stem cells (CSCs) by hypoxia. Both hypoxia and NF-κB pathway plays a pivotal role in the maintenance of stemness in hypoxia-induced CSCs leading to upregulation of anti-apoptotic signalling, chemo-radiation resistance and metastasis. …
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