Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"Cancer phenotype"”.
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Pyrimidine nucleotide carrier 1 in mitochondrial homeostasis and cancer
Abnormal metabolism has been a known feature of cancer for close to a decade, with mitochondrial dysfunction, aerobic glycolysis, and abnormal biosynthetic metabolism present in many cancers. Dysfunctional mitochondria alone have been shown to significantly influence cancer phenotype. Mitochondrial …
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THE EFFECTS OF ACIDOSIS ON SURVIVAL PATHWAYS IN LYMPHOID MALIGNANCIES
… in the field has revealed that, within tumors, cancer cells must grow and develop amidst an increasingly complex and demanding background. Cancer cells acquire the ability to recognize and respond to numerous features of this tumor microenvironment, generating a cellular-environmental crosstalk …
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Halting the neural progression of cancer
… a tumor, is indicative of a more aggressive cancer phenotype. The aim of this thesis project was to investigate the role that axonogenesis and nerve-cancer interactions play in the progression of cancer and whether the SEMA3F/NRP2 axis could be targeted to inhibit this process. We …
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Fragment synthesis: pharmacophore and diversity oriented approaches
… CK2 was chosen due to its importance in the cancer phenotype. A literature fragment, NMR154L, proved to be a promising compound for fragment development, due to its binding at the interface site of the protein rather than the highly conserved ATP pocket. Analogues were synthesised of this …
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A Systems Biology Approach to Microbiology and Cancer
… to investigate how normal breast cells become cancerous (Chapter 5). To date, our intracellular model is the only expanded core iron model that can capture a breast cancer phenotype by overexpression and knockout simulations.
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Notch Signaling Is Important in the Survival, Proliferation, and Self-Renewal of the Putative Breast Cancer Stem Cell Population
… studies have identified stem-like cells, termed cancer stem cells (CSCs), in breast tumors and established cell lines. It has been hypothesized that CSCs are responsible for breast cancer formation, progression and recurrence; therefore, a deeper understanding of the signaling pathways regulating …
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Regulation of MINK1 by APC, PKA and MARK3/4 and consequences for epithelial cell biology
Colorectal cancer is the third most common cause of cancer-related deaths in the developed world. In most colorectal cancers the tumour suppressor gene adenomatous polyposis coli (APC) is mutated. The APC protein is closely linked to epithelial tissue homeostasis, it is a scaffolding protein in Wnt …
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The role of T-box transcription factor TBX3 in rhabdomyosarcoma
Cancer remains one of the leading causes of death worldwide due to late diagnosis and ineffective treatment options. To address this problem requires the elucidation of the molecular mechanisms, including the signaling pathways and transcription factors that drive cancer initiation and progression. …
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Analysis of alterations in the human cancer genome
… regarding the contribution of aneuploidy to the cancer phenotype. In this thesis, we develop computational methods to infer the presence and specific patterns of aneuploidy across thousands of primary cancer tissue specimens. We then combine these inferences with clinical and genomic features of …
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Gcn5 Loss Impacts Myc-Driven Cancer In Mice and Human Cells
… MYC, a protein that amplifies the expression of cancer-promoting genes and is frequently dysregulated in cancer, increasing its stability. Our lab has found there is a significant overlap in the target genes of GCN5 and c-MYC in mouse embryonic stem cells. Recent studies have also implicated GCN5 …
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The cholesterol efflux protein ABCA1 skews macrophages towards an anti-tumor phenotype and consequently impacts cancer progression
Breast cancer is the most common and second-leading cause of cancer-related fatalities in women in the United States. The primary cause of mortality is often the recurrence of metastatic breast cancer. While immunotherapy shows some effectiveness, it has only been approved for patients who stain …
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Patterns of somatic genome rearrangement in human cancer
Cancer development is driven by somatic genome alterations, ranging from single point mutations to larger structural variants (SV) affecting kilobases to megabases of one or more chromosomes. Studies of somatic rearrangement have previously been limited by a paucity of whole genome sequencing data, …
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Mathematical Modeling of Cancer Tumor Evolution
<p>Several mathematical models of cancer tumor evolution are presented. The aim of this endeavor is to write a thesis that fosters numerical and analytical understanding of certain mathematical models in the area of oncology as well as to offer potential predictive tools of therapeutic and clinical …
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Modulating the expression and activity of the nuclear import protein, Karyopherin β1, in cancer cells
Cancer is primarily a disease of disordered gene expression; the dysregulation of thousands of different genes has been associated with the progression of many types of cancer. Previous research from our laboratory aimed at identifying genes differentially expressed in cervical cancer compared to …
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Investigating the role of a FAM111B mutation in hereditary fibrosing poikiloderma (POIKTMP) using induced pluripotent stem cell (iPSC) model
… that recapitulate some parts of the POIKTMP phenotype will need to be created. Future work will also explore the gain-of-function hypothesis to further understand the role of FAM111B in fibrosis and cancer phenotype in POIKTMP.
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Application and Evaluation of a Chemical Modification- and Mass Spectrometry-Based Thermodynamic Assay for the Study of Protein-Ligand Interactions in Complex Mixtures
… on two small molecules with a specific anti-cancer phenotype in human colon cancer cells. These studies identified 17 proteins as potential "hits" of these two small molecules. After preliminary validation of these proteins, approximately 50% were eliminated as false positives and one …
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The Role of METTL21A in Kras-driven Cancers
… the human proteome, and many were implicated in cancer etiology. However, the catalytic activity and substrate specificity for many of these enzymes remain unknown. Our work aimed to explore the role of Methyltransferase like 21A (METTL21A), amember of the little-studied seven β- strand family of …
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Identifying novel drugs for the treatment of rhabdomyosarcoma
… AJ-5, was investigated for its anti-cancer activity and its mechanism(s) of action in RMS cells. The second approach involved a target-based drug repurposing strategy where a library of FDA-approved drugs was screened to identify leads that were able to negatively regulate the …
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HIV alters the expression of miRNA hsa-miR-200c-3p in B-cells, leading to enhanced migration of lymphoma cells
… Burkitt’s lymphoma (BL), a highly aggressive cancer, is one of the most common NHLs associated with HIV infection. Despite receiving highly active anti-retroviral therapy, the prognosis for this HIV-associated lymphoma remains poor and the incidence keeps on increasing in this group of …
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