Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Cancer pathways"”.
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Computational methods for personalized cancer genomics
In recent years, cancer treatment strategies have moved towards personalized approaches, specifically tailoring cancer treatments on a single-patient basis using molecular profiles from the patients’ tumor genomes. Knowledge of a patient’s molecular profile can be used to 1) identify the disease …
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A Tail-Based Test For Differential Expression Analysis and Pathway Analysis In Rna-Sequencing Data
… results. An application on non-small cell lung cancer pathways from KEGG pathway Database also demonstrates the proposed test is a powerful method in detecting differentially expressed pathways.</p>
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Elucidation of the pathways underlying the spectrum of cancers affecting different tissues in lynch syndrome
… individuals to an increased risk of several cancers, particularly colorectal cancer (CRC) and endometrial cancer (EC). LS arises from constitutional (“germline”) pathogenic variants affecting one of four DNA mismatch repair (MMR) genes. When coupled with somatic mutations (“second hits”) in …
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Proteins Involved in HDACi Induced Decay of ERBB2 Transcripts in Breast Cancer
<p>ERBB2-positive breast cancer is an aggressive disease form that can result in rapid tumor growth and metastasis driven by the overexpression of ERBB2 growth factor receptors present on the cell surface. Currently, approved agents can target and disable ERBB2 receptor function, but as few as 30% …
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Stage-specific profiling of the transcriptome during oogenesis and identification of a novel type of small RNA within the zebrafish ($\textit{Danio rerio}$)
… biological processes, and even diseases, such as cancer. Pathways and developmental programs are often highly conserved between organisms, especially vertebrates, allowing for studies within model organisms to have implications in humans. Zebrafish have long been used in the study of developmental …
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Investigation of protein biomarkers in HIV positive and HIV negative associated DLBCL
… samples were compared and characterized by cancer pathways. Results: This study had 12 DLBCL cases and 2 human tonsil controls diagnosed from 2009- 2011. These cases were retrieved using the NHLS database. The overall age of DLBCL patients by the time they were diagnosed ranged from 18 to 73 …
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Structure and Function of HAMLET: Epitopes, Membrane Interactions and Molecular Recognition
… to HAMLET. Furthermore, oleate did not trigger cancer related gene expression. Cellular responses to oleic acid were weak or absent, suggesting that fatty acids exert some of their essential effects on host cells when in the deprotonated state. The results highlight the unique properties of the …
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Observing the effects of acetylcholinesterase and brain-derived neurotrophic factor on the levels of soluble amyloid precusor protein α in lung cancer cell media
<p>Previous studies in our lab found that media from H1299 cells have lower levels of acetylcholinesterase (AChE) and intact amyloid-β40/42 (Aβ), and higher levels of mature brain-derived neurotrophic factor (mBDNF) when compared to A549 cell media. In conjunction to this the levels of soluble …