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Showing 1 to 6 of 6 for “"Cancer modeling"”.
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Robust numerical methods to solve differential equations arising in cancer modeling
Cancer is a complex disease that involves a sequence of gene-environment interactions in a progressive process that cannot occur without dysfunction in multiple systems. From a mathematical point of view, the sequence of gene-environment interactions often leads to mathematical models which are …
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Basal-like breast cancer: modeling its initiation and characterizing novel EGFR variants
Breast cancer (BC) is now a disease that will affect 1 out of every 8 women worldwide. Due to its highly heterogeneous nature, BC is usually further classified into different subtypes according to gene expression profiling analysis. Basal-like breast cancer (BBC) accounts for 15-20% of all cases of …
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Mathematical Modeling of Vascular Tumor Growth and Development
Mathematical modeling of cancer is of significant interest due to its potential to aid in our understanding of the disease, including investigation into which factors are most important in the progression of cancer. With this knowledge and model different paths of treatment can be examined; (e.g. …
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Multi-Omics Analysis of 3D SKOV3 Ovarian Cancer Model Cell line Cultured on Novel Silicon-Titanium Diboride Micropatterned Substrate
Ovarian cancer (OC) remains one of the deadliest cancers affecting women globally, with an estimated number of three hundred thousand new cases and about two hundred thousand deaths annually. The 5-year survival rate of ovarian cancer is approximately 30% or less when diagnosed during the advanced …
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Modeling Cancer Using Li-Fraumeni Syndrome Patient-Derived Induced Pluripotent Stem Cells
… malignancies, including osteosarcoma and breast cancer. In the previous study, our group developed a novel disease model platform by reprograming LFS patients' fibroblasts to induced pluripotent stem cells (iPSCs), and further differentiate these iPSCs into mesenchymal stem cells (MSCs) then to …
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Υπολογιστικές προσομοιώσεις διαγνωστικών και θεραπευτικών τεχνικών που αφορούν σε φυσιολογικά και παθολογικά κυτταρικά συστήματα
… κυττάρων, τα καρκινικά βλαστικά κύτταρα (cancer stem cells), και έχει επεκταθεί ώστε να περιλαμβάνει σε μεγαλύτερη λεπτομέρεια διάφορους βιολογικούς μηχανισμούς σε μοριακό (πχ. εκφράσεις γονιδίων) και κυτταρικό επίπεδο. Ο μηχανισμός δράσης, η φαρμακοκινητική και η φαρμακοδυναμική των …