Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 226 for “"Cancer metastasis"”.
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Biomechanical regulation of cancer metastasis
Metastasis is the ultimate cause of most cancer-related deaths. As such, it is critical to understand the processes that control the spread of cancer through the body. To metastasize, cancer cells must leave the primary tumor, access the circulatory system, adhere to the endothelium of the …
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MUC13 Enhances Colorectal Cancer Metastasis
<p>Colorectal cancer (CRC) is one of the most prevalent cancer worldwide with a 5% lifetime incidence in developed countries. It is third most common cause of cancer related death in the United States and the second deadliest when men and women are combined. Encouragingly due to changes in dietary …
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Germline Genetic Modulator of Cancer Metastasis
<p>Metastasis formation is the most critical determinant of cancer survival outcome. Identifying patients at risk for metastatic relapse facilitates clinical decision and the use of appropriate adjuvant therapy, thus having a profound impact on patient survival. A central dogma in cancer is that …
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Cancer metastasis and elasticity of microenvironment
Cancer deaths are primarily caused by metastases, not by the parent tumor. During metastasis, malignant cells detach from the parent tumor, and spread through circulatory system to invade new tissues. Due to the intrinsic difficulties of predicting and monitoring in vivo metastasis, the …
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Single-Cell Lineage Tracing Of Cancer Metastasis
The underpinnings of cancer metastasis remain poorly understood, in part due to a lack of tools for probing their emergence at high resolution. Here we present macsGESTALT, an inducible CRISPR-Cas9-based lineage recorder with highly efficient single-cell capture of both transcriptional and …
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Wnt-5a signaling in breast cancer metastasis
Breast cancer is the most common form of malignancy affecting women in the Western world. Today, anticancer treatment can control primary breast tumors, but treatment and prevention of metastatic disease still represents a major challenge in the management of breast cancer patients. It has been …
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Role of ATRX in colorectal cancer metastasis
… repair. ATRX is frequently mutated in many cancer types and in colorectal cancer (CRC) loss of ATRX is associated with the CRIS-B subtype, poor prognosis, and late stage and metastatic disease. There are currently few therapeutic options for patients with metastatic disease and accordingly, …
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Fluid Shear Stress Effects on Cancer Metastasis
Metastasis is responsible for at least 66% of cancer-related deaths, yet it remains a poorly understood phenomenon. Fluid shear stress is common to all metastatic events but its effects on circulating tumor cells (CTCs) remains a mystery. It is known that shear stress can act either directly, …
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ROLE OF NOTCH SIGNALING IN BREAST CANCER METASTASIS
… role of hypoxia-induced Notch signaling in tumor metastasis is as yet poorly understood. In the first part of this study, we aimed to define the mechanism of Notch ligand activation by hypoxia in both primary tumor and bone stromal cells in the metastatic niche and to clarify their roles in tumor …
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Molecular and Metabolic Regulation of Gastrointestinal Cancer Metastasis
<p>Most of the cancer related mortality caused by metastatic disease rather than primary tumor growth. More than 80% of gastrointestinal cancers initially metastasize to the liver first. While the prognosis of early-stage cancers is improving, a significant proportion of patients have metastatic …
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THE ROLE OF FAM3C IN LUNG CANCER METASTASIS
Lung cancer is the leading cause of cancer related deaths worldwide. The mechanisms of lung cancer metastasis are not completely understood. This field of research has garnered renewed interest ever since the discovery of vesicle-based cell-cell communication mediated by exosomes. In this study, …
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Genistein suppresses colon cancer metastasis through epigenetic regulations
Colorectal cancer (CRC) is the third most common cancer in the United States. Approximately 90% of colon cancer deaths arise from cancer metastasis, the process by which primary tumors invade into and start to proliferate in a distant new site. Dietary factors are closely associated with …
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Targeting Thromboxane A2 Receptor Signaling in Breast Cancer Metastasis
Breast cancer is the most common type of cancer among women in the United States and metastasis is the leading cause of mortality in patients diagnosed with malignant breast cancer. The receptor of thromboxane A2 (TxA2), TP, is a member of the G-protein coupled receptor family. Increased expression …
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Protein Regulators of Phosphoinositides as Promoters of Cancer Metastasis
<p>Metastasis, the spread of cancer cells from a primary tumor to a distal organ, represents the predominant cause of mortality in patients with solid tumors. However, the molecular mechanisms underpinning this multistep progression are poorly defined. Successful metastasis requires a cancer cell …
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Regulation of Matrix Metallopeptidase-1 in Breast Cancer Metastasis
… repeatedly been correlated to tumorigenesis and metastasis. Yet, MMP-1 regulation in a metastatic context remains largely unknown. Here we confirm differential MMP-1 expression in mammary carcinoma cells with varied metastatic potentials and identify a mechanism differentially regulating MMP-1. …
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The effect of dietary genistein on breast cancer metastasis
… may have the potential to alter breast cancer (BC) growth and metastasis which is also more common in the postmenopausal age group. In this study, we investigated the role of the main soy isoflavone, genistein, on the metastasis of 4T1 murine BC cells implanted in ovariectomized (OVX) …
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Engineered approaches to querying the microenvironment of cancer metastasis
Cancer metastasis is the underlying mechanism of 90% of cancer-related deaths, yet few therapeutics exist that directly target it. Part of this scarcity is attributable to a general lack of knowledge with regards to the underlying mechanisms that mediate traversal of the sequential steps required …
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Novel mechanisms of endothelial-epithelial interactions underlying cancer metastasis
Elucidation of molecular mechanisms underlying metastasis is the final frontier in cancer biology research. Identifying individual pathways in the metastatic cascade could lead to development of metastasis-specific therapeutics; however, current in vivo metastasis model systems are not efficient …
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An investigation into the mechanisms of angiogenesis and breast cancer metastasis
Breast cancer survival rates have increased over the years due to early detection and therapeutic efficacy. However, after many years of what appears to be disease-free health, cancer can return in the form of a secondary metastatic tumour. Formation of new blood vessels is a crucial stage in the …
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