Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 69 for “"Cancer metabolism"”.
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Examining cancer metabolism in vivo
Nutrient requirements for cancer cells are different from those of most normal cells. Understanding these differences, and the factors that are responsible for creating different metabolic dependencies, is critical to understanding the basic requirements of rapid proliferation and identifying …
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PRUNE_1 INVOLMENT IN TNBC ENHANCING CANCER METABOLISM
… depend on the metabolic reprogramming of cancer cells to meet heightened energy and biosynthetic demands. Triple-Negative Breast Cancer (TNBC), characterized by the absence of hormone and HER2 receptors, exhibits high glycolytic and oxidative phosphorylation (OXPHOS) activity, contributing …
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Interrogating Cancer Metabolism using Novel Imaging Techniques
Altered metabolism is one of the hallmarks of cancer and is known to enable the proliferation and survival of cancer cells in changing microenvironments. Metabolic changes can be interrogated using non-invasive metabolic imaging techniques, which enable the investigation of tumour metabolism in …
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Preserving hyperpolarised nuclear spin order to study cancer metabolism
Monitoring the early responses of tumours to treatment is a crucial element in guiding therapy and increasing patient survival. To achieve this, we are using magnetic resonance imaging (MRI), which can provide detailed physiological information with relatively high temporal and spatial resolution. …
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Exploring cancer metabolism through isotopic tracing and metabolic flux analysis
Cancer is the second leading cause of death following heart diseases in the U.S. During the past two decades, cancer metabolism has emerged as an indispensable part of contemporary cancer research. Various types of metabolic alterations in cancer cells have been documented, prompting extensive …
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Regulation of Substrate Degradation and Cancer Metabolism by the Fbw7 Ubiquitin Ligase
… suppressor that is frequently mutated in human cancers; accordingly, many of Fbw7’s substrates are potent oncoproteins. It is through the deregulation of substrate degradation that Fbw7 mutations exert their oncogenic effects. For my dissertation, I studied two aspects of Fbw7 biology: the …
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Altered Ovarian Cancer Metabolism Increases Neuronal N-Acetylaspartate to Promote Tumor Growth
<p>Background: Altered metabolism is a well-established trait in many cancers, and is an emerging hallmark of cancer. Recent resurgence of cancer metabolism studies has identified dysregulated metabolic pathways that produce novel oncometabolites in various cancers. However, large scale studies of …
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NQO1-Bioactivatable Drugs at the Interface of Cancer Metabolism and the DNA Damage Response
… species (ROS) have been observed in multiple cancer types, where they are crucial for tumor biology. Concomitantly, tumor cells also have enhanced expression of antioxidant pathway proteins to detoxify excess ROS. Thus, a challenge for anti-cancer therapeutics is to fine-tune this delicate …
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The Role of UCP2 in Pancreatic Cancer Metabolism and Its Potential as a Radiosensitizer
… generation. In tumors, specifically pancreatic cancer (PDAC), the ETC is highly stimulated to generate the copious ATP needed by the tumor to grow. However, extended ETC use increases reactive oxygen species (ROS), and if left unchecked, results in cell death. To evade this, PDAC employs …
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Study of the differential compartmentation and functions of hexokinase isoforms and implications for cancer metabolism
… is a very important consideration when designing cancer treatment. Therefore, targeting cancer-specific isoforms of key metabolic enzymes is a very promising strategy. Elevated glucose consumption and lactate secretion under aerobic conditions is a hallmark of many cancer cells. One of the major …
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TARGETING CANCER METABOLISM WITH FASTING-MIMICKING DIET¿BASED LOW-TOXIC COMBINATION THERAPIES: OVERCOMING RESISTANCE THROUGH METABOLIC SYNERGY
Aging represents the highest risk factor for cancer, defined by molecular hallmarks such as genomic instability, telomere attrition, deregulated nutrient sensing, and chronic inflammation promoting malignant transformation. Among age-associated cancers, non-small cell lung cancer (NSCLC) is the …
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Investigating the Therapeutic Potential of L-asparaginase in Myeloid Leukemia
… a growing body of evidence has demonstrated cancer metabolism is a distinctive trait that can be targeted by reducing nutrient availability. Therefore it is plausible that cancer metabolism will be affected by L-asparaginase treatment, in addition to the well-established protein synthesis …
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The influence of nutrient availability on tumor metabolism
… (TME). Nutrient accessibility not only shapes cancer metabolism but also affects therapeutic responses, genetic dependencies, and metastatic behavior. This dissertation explores how nutrient availability modulates these cancer phenotypes. First, we examined how environmental nutrient levels …
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Genomic nucleic acid memory storage with directed endonucleases
… mutations. To demonstrate a system to monitor cancer metabolism, guide RNA is expressed in mammalian cell culture with a NF-kappaB promoter. To demonstrate a system that can monitor sugar intake in an environment like the gut, guide RNA is expressed in bacteria with an arabinose promoter.
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ELUCIDATING THE ROLE OF BCAT1 IN MITOCHONDRIAL FUNCTION AND NEURODEVELOPMENT
… Isoleucine, and Valine. Regulation of BCAA metabolism influences the central nervous system through multiple mechanisms, including the reversible deamination of BCAAs by branched-chain aminotransferase 1 (BCAT1). While BCAT1 dysregulation is established in cancer metabolism and immune cell …
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The effects of per- and polyfluoroalkyl substances (PFAS) and high fat diet on metabolism, reproductive health & prostate cancer progression
… fatty liver disease, infertility, and cancer. Epidemiological studies suggested a link between increased blood PFAS levels and prostate cancer incidence, but the mechanism of action for such a phenomenon is unknown. In the present thesis research, we investigated how PFAS impacts …
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An integrated approach to understanding the metabolic rewiring of cancer cells
Cancer remains a leading worldwide health problem, and in the U.S., 1 in 3 women and 1 in 2 men are expected to develop it during their lifetimes. While the last several decades have provided tremendous understanding of the genetic mutations and signaling pathways that give rise to oncogenic …
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A Study On The Function of 14-3-3Sigma In Regulating Cancer Energy Metabolism
… reprogramming has been shown to be a major cancer hallmark providing tumor cells with significant advantages for survival, proliferation, growth, metastasis and resistance against anti-cancer therapies. Glycolysis, glutaminolysis and mitochondrial biogenesis are among the most essential …
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Catalytic-Independent And Subtype-Specific Roles Of Fructose-1,6-Bisphosphatase 2 In Sarcoma Growth
… emerging roles in sarcoma malignancy. Altered cancer metabolism influences tumor growth through both enzymatic and non-enzymatic mechanisms; however, FBP2’s catalytic activity-independent functions are not fully defined. Here, we demonstrate that FBP2 exerts subtype-specific effects on sarcoma …
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Genomic Discovery of recurrent CD44-SLC1A2 Gene Fusion in Gastric Cancer
… various genomic abnormalities associated with cancers, fusion genes and transcripts are particularly notable due to their cancer-specific nature and translational potential as diagnostic and therapeutic targets. While fusion genes are well-known in haematological malignancies, our knowledge of …
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