Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"Cancer markers"”.
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Chip -Based Detection of Protein Cancer Markers
Made available in DSpace on 2015-09-25T19:48:44Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 3301266.pdf: 3002133 bytes, checksum: 7d630bc60357b50465e972f28005c702 (MD5) Previous issue date: 2007
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A cell level automated approach for quantifying antibody staining in immunohistochemistry images. A structural approach for quantifying antibody staining in colonic cancer spheroid images by integrating image processing and machine learning towards the implementation of computer aided scoring of cancer markers.
… in the pathologist¿s diagnosis and monitoring of cancer development. The manual process of monitoring such images is a subjective, time consuming process that typically relies on the visual ability and experience level of the pathologist. A novel and comprehensive system for the automated …
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NON INVASIVE CANCER DETECTION: FROM BENCH TO BEDSIDE
Cancer stands second in causing mortality worldwide. Cancer can be curable if the disease is identified at early stages. All the existing gold standard cancer diagnosing procedures were invasive and expensive. Mass screening for cancer could save a lot of lives. The diagnostic procedure should be …
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Concurrent detection and isolation of cellular and molecular biomarkers
<p>Detection of cancer markers such as protein biomolecules and cancer cells in bodily fluids is of great importance in early diagnosis, prognosis as well as evaluation of therapy efficacy. Numerous devices have been developed for detecting either cellular or molecular targets, however there has …
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Proteomic analysis of biomarkers associated with immunotherapy in murine tumour models
… and identification of important protein biomarkers. Such candidate biomarkers can potentially be used for diagnosis, prognosis and monitoring a variety of diseases as well as the prediction of therapy response. Mass spectrometry has been used widely, for the discovery and quantitation of …
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Mouse Melanoma Model for Evaluating Anti-Cancer Effects of Nanoparticles, Composites and Conjugates
Melanoma is a detrimental cancer due to its ability to evade the immune system and replicate uncontrollably. Tumor cells are thought to change their local microenvironment, both to evade the repression by the immune system and to use expressed cytokines and factors for their advanced growth and …
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Luminescent Quantum Dot and Protein Composite Nanoparticles for Bioanalytical Applications
… the detection of a protein expressed by breast cancer cells. The second project focused in more detail on the detection capabilities of the quantum dot-silica composites. Three different types of quantum dot-silica composites were prepared. Each type was loaded with a separate type of quantum …
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Mass Spectrometric Characterization of the MCF7 Cancer Cell Line: Proteome Profile and Cancer Biomarkers
The discovery of cancer biomarkers is crucial in the clinical setting to facilitate early diagnosis and treatment, thereby increasing survival rates. Proteomic technologies with mass spectrometry detection (MS) have the potential to affect the entire spectrum of cancer research by identifying these …
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Glycosylation of Prostate Cancer Cell Lines and Glycosyltransferase Characterization and Inhibition
Altered glycosylation is a hallmark of cancer and can be used to distinguish cancer cells from normal cells. This thesis shows a comprehensive study of glycosylation on a variety of human prostate cell lines. Cell surface glycans were analyzed using lectins and antibodies. Glycans were also …
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Design, Synthesis and Study of Novel Multivalent Ligands - Toward New Markers of Cancer Cells
Cancer is lacking early detection methods and treatment specificity. In order to increase the sensitivity and specificity towards cancer cells, we propose the use of multivalent interactions targeting specific receptor combinations at the cancer cell surface. In this thesis, we explored the design …
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Validation of an aASPH-SNAP-tag fusion protein for immunodiagnosis of triple-negative breast cancer
Breast cancer is a serious health concern for women from as young as 20 years old and to this day is well known to be the leading cause of cancer incidences and mortalities in females. This disease is known as a heterogeneous disease that requires different systemic therapies, therefore early …
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Development of the chick chorioallantoic membrane (CAM) xenograft model to study metastasis and angiogenesis in autophagy deficient osteosarcoma cells
… (OS) is the most common primary malignant bone cancer in children. Despite the improvement in multiagent chemotherapy, 5-year survival rate for metastatic OS is only 20% to 30%. One of the main reasons for failure in therapy is due to the activation of autophagy in metastasis and angiogenesis, …
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Detecting and molecular profiling cancer cells in patients
… our understanding of the molecular signatures of cancer in clinical samples. In the first section, we describe a diagnostic magnetic resonance (DMR) device that was developed for point-of-care analyses of human tumors. We optimized a magnetic nanoparticle assay to improve sensitivity and …
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Synthesis and Characterization of Multi-Functional Nanoparticles for Therapeutic and Biosensing Applications
… derivative, a model therapeutic enzyme, and anticancer drugs. The protein hormone release from biodegradable nanoparticles prepared using double emulsion solvent evaporation was quantified and release phases were identified. Insulin-like growth factor (IGF1)-loaded nanoparticles showed that the …
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Design and optimization of ultrathin silicon field effect transistor's for sensitive, electronic-based detection of biological analytes
… of these were due to such chronic illnesses as cancer, cardiovascular disease, diabetes, and lung disease. Moreover, the prevalence of these diseases is rising fastest in low-income regions which have little resources to combat these large, yet avoidable costs. In particular, over 1.6 million …