Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 17 of 17 for “"Cancer in children"”.
-
Neuropsychological outcomes in children treated with surgery for brain tumour
Brain tumours are the second most c o m m o n form of cancer in children. The majority of children treated for brain tumour survive, but they can experience a number of neurological and neuropsychological sequelae. A range of tumour, treatment, and psychosocial factors cumulatively and …
-
Services for children with cancer : the views of parents, professionals and relevant charities
In adopting a tabula rasa approach, this study sought to determine those elements of care that should be prioritised in the service provision for families with children who have cancer. An innovative approach was adopted, as opposed to a conventional thesis structure, in which the literature in …
-
Childhood cancer within a family and medical context in eThekwini : strengthening psychosocial and spiritual interventions to enable coping and healing
A thesis submitted in fulfilment of the requirements for the Degree of Doctor of Philosophy in Health Sciences, Durban University of Technology, Durban, South Africa, 2025.
-
Anticancer Potential of Soy Peptides
Leukemia is the most common type of cancer in children. Various topoisomerase inhibitors are currently used in the treatment of leukemia. Epidemiological studies have associated soy consumption with lowering cancer risk. However, the anticancer potential and mechanism of soy peptides have not been …
-
Regulation of autophagy, endoplasmic reticulum and unfolded protein response by glucocorticoids in physiology and disease
… leukemia (ALL) is the most frequent cancer in children, and although highly treatable, challenges remain due to significant side effects of therapy and the poor outcome for some patients. Synthetic glucocorticoid, Dexamethasone (Dex), has been used to treat several haematological …
-
Development of the chick chorioallantoic membrane (CAM) xenograft model to study metastasis and angiogenesis in autophagy deficient osteosarcoma cells
… (OS) is the most common primary malignant bone cancer in children. Despite the improvement in multiagent chemotherapy, 5-year survival rate for metastatic OS is only 20% to 30%. One of the main reasons for failure in therapy is due to the activation of autophagy in metastasis and angiogenesis, …
-
Computer Aided Diagnosis Systems for Digital Analysis of Osteosarcoma and Skin Cancer
… (CAD) systems assist medical professionals in the interpretation of medical images. Many image modalities such as X-ray, MRI, and ultrasound already have diagnostics systems that process digital images for regions of interest and compute diagnostic patterns to provide supporting information …
-
Infertility and infertility treatment: childhood cancer and epigenetic risks.
Although childhood cancer is rare, it can have a devastating impact on the children who develop it and their families. Just as in adults, cancer in children is comprised of many disease types. Since the window for exposure is quite limited in childhood cancer, exposures encountered in utero are …
-
Developing Targeted Therapies for T-cell Acute Lymphoblastic Leukemia
<strong>Introduction</strong> Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and risk-adapted chemotherapies have dramatically improved the outcomes of this disease. Compared to B-cell ALL, T-cell ALL (T-ALL) is more aggressive and has worse outcomes from chemotherapy. …
-
Hierarchical neuropsychological functioning in pediatric survivors of acute lymphoblastic leukemia.
… is one of the most common types of pediatric cancers. Improvements in treatment within the last 20 years have resulted in reduced mortality and a greater focus upon quality of life. Several researchers have documented neuropsychological impairments in children following treatment for ALL; …
-
The psychosocial functioning in pediatric cancer survivors: The role of neurocognitive abilities.
With the increase in survival for children with cancer, part of the focus of current research is aimed towards evaluating how these children are adapting psychosocially. Neurocognitive deficits have been well established. However, there are multiple facets encompassing quality of life, including …
-
Novel therapies for cancer treatment : designing high affinity selective ligands against SIRT1 enzyme
The word ‘Sirtuin’ or Sir2 proteins are a class of proteins that possess either mono-ADP-ribosyltransferase, or deacylase activity, including deacetylase. SIRT1 is the most studied mammalian Sirtuins and predominantly localised in the nucleus and cytoplasm. Many Sirtuins targets are involved in …
-
Assisting student cancer survivors to re-enter the school setting
The tremendous increase in the survival rates of children diagnosed with childhood cancer has created an ever-growing number of children who are re-entering school during or after treatment for childhood cancer. Furthermore, there are many long-term side effects following the treatment for …
-
Genetic factors in childhood cancer. Associations between tumors in childhood and adulthood, and prevalence of germline TP53 mutations
The etiology of childhood cancer is largely unknown. Approximately 1-10% of all childhood tumors are associated with known cancer predisposition syndromes. However, the contribution may be underestimated due to the failure to detect patients with genetic susceptibility for cancer when relying on …
-
Depression, Anxiety, Self-Esteem, and Coping in Children and Adolescents Newly Diagnosed with Cancer and Children and Adolescents on Cancer Treatment for a Period of Seven Months or Longer
Differences in self-reported depression, anxiety, self-esteem, and coping were evaluated in two groups of pediatric oncology patients: newly diagnosed (less than six months post-diagnosis) (n=5) and patients on cancer treatment for seven months or longer (n=5). Participants (6 males, 4 females, …
-
The Relationship between Executive and Psychosocial Functioning in Children Treated for a Brain Tumor
This study examined the relationship between executive and psychosocial functioning in 45 children and adolescents age 6 to 17 years who had been treated for a brain tumor. Executive functioning deficits can profoundly impact an adult's ability to function successfully in life. The purpose of the …