Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"Cancer hallmarks"”.
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Physiological Oxygen and Media Conditions Influence Breast Cancer Hallmarks in Vitro
… the effects of both media and O2 on breast cancer cells in culture, particularly focusing on cancer hallmarks at the levels of gene expression, metabolism, and proliferation. To that end, I cultured MCF7 cells in 18% O2 or 5% O2 and in DMEM or Plasmax, a recently developed medium with …
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The Cell Membrane Proteome of the SKBR3/HER2+ Cells and Implications for Cancer Targeted Therapies
Breast cancer is the second most common type of cancer among women in the US and the second leading cause of cancer death. HER2+ breast cancers represent ~20% of all cancer types, are highly invasive, and can be treated by using targeted therapies against the HER2 receptor. However, these therapies …
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Igfbp2 Potentiates Egfr-Stat3 Signaling In Glioma
… functions. Despite a clear causal role in cancer development, the contributions of intracellular IGFBP2 to tumor development and progression are poorly understood. Here we present evidence that both exogenous IGFBP2 treatment and cellular IGFBP2 overexpression lead to aberrant activation of …
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Synthetic Essentiality of Tdo2 In Apc-Mutated Colorectal Cancer
… is</p> <p>common genetic event across many cancers and serves a critical initiating</p> <p>event in the majority of sporadic colorectal cancers (CRC). The WNT/APC</p> <p>pathway remains an elusive target for cancer, prompting us to explore</p> <p>orthogonal strategies to identify specific …
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Dissecting the Role of Novel O-GlcNAcylation of NF-κB in Pancreatic Cancer
… genes, which play a role in perpetuating major cancer hallmarks. We further show that overexpression of the p65 mutants inhibited PDAC cellular proliferation, migration, and anchorage-independent growth compared to WT-p65. We also show that inhibition of NF-κB O-GlcNAcylation may mitigate …
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BRIDGING TRANSCRIPTION AND SIGNALING TO STUDY C-MYC FUNCTION AND REGULATION IN CANCER CELLS
… and is frequently deregulated in human cancers. Despite the prevalent role of MYC in cancers, no MYC inhibitors are currently available for clinical use. In this work, we investigated the molecular mechanisms underlying MYC’s transcriptional function and deregulation using an integrated …
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Semantic text classification for cancer text mining
Cancer researchers and oncologists benefit greatly from text mining major knowledge sources in biomedicine such as PubMed. Fundamentally, text mining depends on accurate text classification. In conventional natural language processing (NLP), this requires experts to annotate scientific text, which …
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Integrative analysis of the metastatic neuroblastoma transcriptome
… a distinct splicing pattern affecting multiple cancer hallmarks. Six splicing factors have altered expression patterns in MYCN-amplified tumors and cell lines, and binding motifs for these factors were significantly enriched in differentially-spliced genes. ChIP-seq analysis showed direct …