Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 29 for “"Cancer genetics"”.
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Analysis of referrals to a cancer genetics service
… referrals for Welsh-domicilled patients to the Cancer Genetics Service for Wales (CGSW) in order to establish what referral patterns exist. CGSW has a patient population of 10,878 first referrals over the eight year period, 1998 to 2006. These data are combined with data on deprivation, GP …
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Breast cancer, medical imaging, and cancer genetics. A new genetic concept regarding the causes and prevention strategies of cancer is presented
Breast cancer is the most common cancer type in the United Kingdom. Many women with breast cancer do not show any noticeable symptoms in their early stages, hence regular breast screening is important. In this research focus is on medical imaging and its role in breast cancer screening, diagnosis, …
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Women's perceptions and attitudes regarding susceptibility to and prevention of breast cancer based on genetic testing
… women's attitudes and perceptions about breast cancer genetics and behavioral intents when considering preventive strategies for breast cancer. The participants were 100 women, of undetermined breast cancer status, in a large metropolitan area of the United Statues, who completed a …
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Genetic differences in lung adenocarcinoma cells from patients of African and European ancestry
In the past two decades, advancements in cancer genetics research have significantly enhanced our molecular comprehension of human cancers. This progress has led to the development of improved clinical tools for the precise diagnosis, prognosis prediction, and tailored treatment of cancers. …
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Knowledge, attitudes, and practise toward cancer genetic testing among healthcare workers in the oncology clinic at Sultan Qaboos Comprehensive Cancer and Research Center (SQCCCRC)
The incidence of cancer is rising and has emerged as a significant public health challenge in Oman. Approximately 5-10% of all cancer cases are attributed to high penetrance genes, which account for inherited forms of cancer. Due to the shortage of genetic counsellors and medical geneticists in …
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The Impact of Genetic Testing in Women with a Diagnosis and Family History of Breast Cancer: A Qualitative Investigation of Patient Experience
Personalised Medicine has the potential to impact cancer prevention, diagnosis, treatment and prognosis. Today efficient, affordable and available early BRCA1/2 screening techniques are now feasible and can provide results to inform treatment. However BRCA1/2 testing, undertaken close to cancer …
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Development of A Bayesian Joint Logistic Model to Better Study The Association Between Haplotypes and Disease
… 2011, there will be an estimated 1,596,670 new cancer cases and 571,950 cancer-related deaths in the US. With the ever-increasing applications of cancer genetics in epidemiology, there is great potential to identify genetic risk factors that would help identify individuals with increased genetic …
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Landscape of Ecdna-Borne Non-Coding Rnas In Glioblastoma
<p>Recent advances in cancer genetics found that strong oncogene transcription can occur on a form of non-chromosome DNAs that is often amplified to tens or hundreds of copies, and that can exist in more than half of cancer types. This type of genetic material was termed extrachromosomal DNA …
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Clinical Applicability of Proposed Algorithm For Identifying Individuals At Risk For Hereditary Hematologic Malignancies
… review at The University of Texas M.D. Anderson Cancer Center. These patients presented for initial consultation from March 1, 2014 to December 31, 2014. Six-hundred and eight individuals diagnosed with MDS/AML/AA were included in this study. Key demographic information was obtained from a …
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Elucidating the constitutional genetic basis of multiple primary tumours
Cancer predisposition syndromes are responsible for a significant minority of neoplasm occurrences and beget opportunities to mitigate the associated risks with clinical intervention. They are caused by constitutional genetic variation affecting tumour suppressor genes or proto-oncogenes and recent …
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Germline HOXB13 G84E Mutation Inhibits MEIS1-HOXB13 Driven Tumor Suppression in Prostate Cancer
Prostate cancer (PrCa) continues to pose a burden to adult men in the United States, having the highest incidence and second highest mortality rates. A prostate cancer diagnosis in an immediate family member increases risk 2-3 fold. Standard of care treatment of PrCa targets the Androgen Receptor …
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Drivers of melanoma susceptibility
Cutaneous melanoma is a cancer of melanocytes, the pigment-producing cells in our skin. It is one of the most aggressive human malignancies, constituting only about 2% of all dermatological cancers but being responsible for over 75% of all deaths from skin cancer. It has recently become a major …
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Studies of Replication Repair Deficient Brain Tumorigenesis Using Mouse Modeling
Replication repair deficiency (RRD) is a pan-cancer mechanism caused by germline and/or somatically acquired deficiency in the replication repair machinery – DNA polymerase proofreading and the mismatch repair (MMR) system. Germline monoallelic (Lynch Syndrome, LS) or biallelic (Constitutional …
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Genetic markers in circulating tumour cells as a measure of the metastatic propensity of uveal melanoma
… have been previously shown to be expressed in cancer, cutaneous melanoma, or UM. We found that 5HT2B, and ABCB5, surface gp100 (BETEB), MCAM, and MCSP were highly expressed in primary UM tissue or UM cell lines and were able to immunomagnetically capture UM cell line cells. Concurrently, we …
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Identification of novel synthetic lethal interactions using multiplexed CRISPR-Cas9 screening
Abstract As our understanding of the cancer genome has progressed, traditional chemotherapeutic agents are being replaced, in part, by targeted therapies. Development of these therapies is driven by our understanding of genetic vulnerabilities harboured by tumours. The aim of this project is to …
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Identification of Familial Wilms Tumor Predisposition Genes Using Whole Genome Sequencing
… live births and accounts for 5% of all pediatric cancers. The etiology of Wilms tumor is heterogeneous with multiple genes known to have an effect on Wilms tumor development; however, these genes are rarely associated with familial Wilms tumor. Gene mutations in <em>WT1</em>, <em>WTX</em>, …
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Outcomes of Genetic Testing In A Genitourinary Genetics Clinic
<p>Several known hereditary cancer syndromes confer an increased risk for genitourinary (GU)related malignancies. Various guidelines indicate when to refer patients to genetic counseling for GU-related hereditary cancer syndromes but there is limited research on the clinical picture of these …
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Production of Extracellular Matrix-Degrading Proteases by a Rat B Cell Line.CRL-1631
Badeaux, K. Production of Extracellular Matrix-Degrading Proteases by a Rat B Cell Line.CRL-1631. Master of Science (Microbiology and Immunology), May 2002. 30 pp., 9 illustrations, 1 table, 16 bibliography titles. Previously B lymphocytes have been reported to accumulate at the site of tumor …
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Identifying Pathogenic Variants In Hereditary Cancer Syndrome Genes Via Tumor Molecular Profiling
… profiling is often performed in order to direct cancer treatment options. However, because many of the genes analyzed on tumor molecular profiling overlap with genes known to be associated in the germline with hereditary cancer predisposition syndromes, tumor molecular profiling can unknowingly …
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