Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Cancer epigenetics"”.
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Diagnostic and Prognostic Biomarkers for Early Prostate Cancer
Prostate cancer is diagnosed and treated primarily on the basis of histopathological assessment of biopsies and cancer extent. Unfortunately, this assessment, performed by pathologists on very small amounts of biopsy tissue, misrepresents patient’s true risk of having life-threatening cancer grade …
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Mechanical and epigenetic regulation of cell plasticity and tumorigenicity
Made available in DSpace on 2015-09-29T21:08:15Z (GMT). No. of bitstreams: 2 SINGH-THESIS-2015.pdf: 283696 bytes, checksum: 0f7e963da95634dafa16e9e9a970da45 (MD5) LICENSE.txt: 4208 bytes, checksum: dd735d55c1189c6cc1ef21be4dc1ab2c (MD5) Previous issue date: 2015-07-22
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Toward an epigenetic classification of human testicular germ cell tumors (TGCTs): preliminary assessment of histone H3-K27 trimethylation according to TGCT subtype, aggressiveness, and response to therapy
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2026-05-01
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Defining and Targeting Epigenetic Rewiring During Tumor Progression
… is the leading cause of death among breast cancer patients. Epigenetic mechanisms are critical for regulation of gene expression and to facilitate appropriate responses to environmental cues. However, it is increasingly appreciated that epigenetic dysregulation directly promotes therapeutic …
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Functional Analysis of Risk Single Nucleotide Polymorphism and Long Noncoding RNA in Prostate Cancer
Prostate cancer is the most commonly diagnosed non-cutaneous cancer in men worldwide. While most low-risk prostate cancer patients have a favourable clinical outcome, intermediate- and high-risk patients with aggressive forms of the disease often relapse despite the initially effective local and …
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Chromatin Regulators of MYC Oncoprotein Activity in Cancer
… contributor to the development of virtually all cancer types. MYC is known as a global regulator of transcription that controls diverse physiological and oncogenic functions. Though there are 35 yearsâ worth of research on this protein, mechanistic understanding and therapeutic targeting of MYC …
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Y Chromosome Gene Kdm5D Epigenetically Drives Sex Differences In Colorectal Cancer
<p>Sex exerts a profound impact on cancer incidence, spectrum and outcomes, yet the molecular genetic bases of such sex differences are ill-defined and presumptively ascribed to X-chromosome genes and sex hormones. Such sex differences are particularly prominent in colorectal cancer (CRC) where men …
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Chronic oxidative stress and susceptibility to renal carcinogenesis
… shared by multiple risk factors of kidney cancer. But there is no experimental evidence to show direct role of oxidative stress in kidney cancer. In this study, our main objective was to evaluate effect of H2O2-induced chronic oxidative stress on neoplastic transformation of normal human …
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Genetic analysis of Kmt2d loss in tumorigenesis using genetically engineered mouse models
<p> The Cancer Genome Atlas Program (TCGA) has discovered multiple tumor suppressors that are commonly mutated across a variety of human cancers, such as chromatin regulators in COMPASS and SWI/SNF complexes. <em>KMT2D</em>, a histone H3K4 methyltransferase in the COMPASS complex, is frequently …
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Unravelling the epigenetic landscape of pancreatic cancer: The role of cancer-associated fibroblasts in transcription factor regulation
… (PDAC) remains one of the deadliest cancers, with limited treatment options and poor survival rates. It is characterised by strong driver mutations, extensive epigenetic reprogramming, and a dense tumour microenvironment (TME). A defining feature of the PDAC TME is its fibrotic …
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Investigating the transcription factor landscape of the squamous subtype of pancreatic ductal adenocarcinoma
… adenocarcinoma (PDAC) is one of the most lethal cancers, characterised by late diagnosis and early onset of metastases, and has a dismal 5-year survival of only 8\%. Based on gene expression profiles PDAC can be stratified into two distinct molecular subtypes: classical and squamous, with the …
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Infertility and infertility treatment: childhood cancer and epigenetic risks.
Although childhood cancer is rare, it can have a devastating impact on the children who develop it and their families. Just as in adults, cancer in children is comprised of many disease types. Since the window for exposure is quite limited in childhood cancer, exposures encountered in utero are …
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An investigation of the impact of the B cell lymphoma factor Activation Induced Cytidine Deaminase (AICDA/AID) on epigenetic plasticity
Cancer is a major cause of both mortality and morbidity globally, with 10 million deaths reported in 2020 by the Global Cancer Observatory (GLOBOCAN). To address this burden, it is crucial to deepen our understanding of the biology of the disease to create opportunities for addressing therapeutic …