Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 6 of 6 for “"Cancer dependency"”.
-
OPTIMISATION AND THERAPEUTIC-TARGET-DISCOVERY ORIENTED ANALYSIS OF CRISPR-CAS9 SCREENS
… of CRISPR-Cas9 technology has revolutionized cancer research by enabling targeted genome modifications in tumour cells, offering insights into cancer biology and potential treatment targets. My PhD research focuses on developing tailored tools and pipelines to enhance the analysis of …
-
Interactive Exploration of Multitask Dependency Networks
… brain develops due to learning; and, learning dependency networks of blood proteins associated with cancer. Dependency networks, or graphical models, are learned from the observed data in order to make comparisons between the sub-populations of the dataset. Rarely is there sufficient data to …
-
Machine Learning Methods for Learning Genetic Dependencies
… a potential avenue for selectively targeting cancer cells based on genetic vulnerabilities. The rise of large-scale gene perturbation screens such as the Cancer Dependency Map (DepMap) offers the opportunity to identify SL pairs automatically using machine learning. We build on a recently …
-
Characterizing glucocorticoid receptor in metastatic castration resistant prostate cancer
… the context of enzalutamide resistant prostate cancer cells. Enzalutamide is a drug that functions to dampen androgen receptor (AR) signaling, thus inhibiting cancer dependency on the receptor protein. Although the application of the drug reduces AR signaling in these cancer cells, an alternate …
-
Regulation of human sex-linked homologs DDX3X and DDX3Y and phenotypic consequences
… for human diseases. We re-analyzed data from the Cancer Dependency Map to identify genetic dependencies on the broadly expressed regulators on the Y chromosome. We find that DDX3Y is required for the survival of a set of cancer cell lines that present with loss-of-function mutations in DDX3X, …
-
Biases and Blind-Spots In Genome-Wide Crispr-Cas9 Knockout Screens
… gene essentiality is particularly important in cancer, since killing cancer cells selectively without harming surrounding healthy tissue remains a major challenge. The toxicity of traditional cancer treatment protocols to the normal cells stresses the need for new strategies that can identify …