Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"Cancer colorectal"”.
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Rôles de la protéine tyrosine phosphatase SHP-2 dans l'inflammation intestinale et le cancer colorectal associé à la colite
… CEI-KO entraîne avec l'âge le développement de cancer colorectal associé à la colite. Finalement, nos résultats chez l'humain montrent qu'il y a une diminution significative d'expression de SHP-2 chez les patients atteints de maladies inflammatoires intestinales comparativement aux patients …
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L’implication de la signalisation des Bmps dans le maintien de l’homéostasie de la muqueuse intestinale et colique et dans les pathologies digestives.
… des rôles importants pour le TGF-β dans le cancer colorectal et l’inflammation intestinale. Cependant, très peu d’études se sont attardées aux rôles pouvant être joués par d’autres membres de la superfamille du TGF-β dans ces pathologies. Dans cette étude, le modèle de souris possédant la …
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Qualité de vie, soutien social et image corporelle d'une personne vivant avec une dérivation digestive fécale permanente
"Le cancer colorectal et les maladies inflammatoires de l'intestin (MII) sont des maladies qui représentent un défi de taille pour les gens atteints et leur famille. Ces personnes gravement malades doivent parfois avoir recours à la création chirurgicale d'un dérivation digestive fécale plus …
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Delineating metastasis in MSS colorectal cancer by single - cell RNA sequencing
<p>Colorectal cancer Colorectal Cancer (CRC) is the leading cause of cancer-related deaths, with the majority of these deaths occurring after metastases. In this study, we used single-cell RNA transcriptome sequencing to characterize the cellular and molecular features of primary CRC and colorectal …
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Caracterización clínica y endoscópica de los pacientes llevados a Colonoscopia en el Hospital Universitario Samaritana 2017-2018
Introducción : En Colombia el cancer colorectal es la cuarta causa de muerte por cancer. La colonoscopia es una estrategia de tamizaje que puede prevenir el desarrollo de lesiones precancerosas. Es importante caracterizar clínica y endoscópicamente la población que es llevada a colonoscopia en …
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Pilot study on Nordic pole walking and individuals with cancer: effects on physical function and health-related quality of life
Individuals diagnosed with cancer experience a high symptom burden that has a significant impact on their quality of life and an individualized, community-based Nordic pole walking (NPW) program may help to alleviate this. The primary objective of this eight-week multi-centred randomized controlled …
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Gene prioritization through hybrid distance-score rank aggregation
… a number of gene sets, including Autism, Breast cancer, Colorectal cancer, Endometriosis, Ischaemic stroke, Leukemia, Lymphoma, and Osteoarthritis. Furthermore, we performed iterative gene discovery for Glioblastoma, Meningioma and Breast cancer, using a sequentially augmented list of training …
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Cancer related fatigue and self-care while undergoing chemotherapy: patients' perspectives
Background: Cancer related fatigue (CRF) is considered the most severe, debilitating and under-managed symptom of cancer. Patients receiving chemotherapy experience high levels of CRF which profoundly impacts on their lives. Aim: 1). To explore and measure CRF and determine the most effective …
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Development of 64Cu/NOTA-terpyridine platinum conjugates as chemoradiotheranostic agents
Le cancer colorectal est l'un des cancers les plus répandus dans le monde et au Canada. Il présente une résistance intrinsèque et acquise aux agents chimiothérapeutiques à base de platine. Plusieurs mécanismes sont impliqués dans la résistance des tumeurs à ces agents, y compris une internalisation …
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Data Management tools For Metagenomic Datasets, A Case Study: Characterization and Dysbiosis of Gut Microbiota In Apcmin/+ Mice With and Without Colon Tumors
… Bowel Disease (IBD), Crohn's disease and even colorectal cancer. Colorectal cancers are the second leading cause of death in the US and it's mainly due to the lack of early detection. If diagnosed at the polyp stage, they can be treated to avert progression of the cancer. But invasive and …
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Investigating FAM83H, a protein mutated in Amelogenesis Imperfecta
… found to be overexpressed in several types of cancer including, androgen independent prostate cancer, colorectal cancer and hepatocellular carcinoma.<br/><br/>This thesis explores the biochemical and cellular roles of FAM83H and some pathogenic AI mutants. A proteomic approach revealed several …
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Mécanismes de contrôle du facteur de transcription E2F4 dans les cellules épithéliales intestinales normales et cancéreuses
… De plus, les mutants d'E2F4 retrouvés dans les cancers colorectaux avec instabilité des microsatellites, E2F4(Ser) 12 et E2F4(Ser)14 , sont plus fortement exprimés en raison d'une stabilité accrue et ont une meilleure activité transcriptionnelle. Nous démontrons aussi l'existence de 2 formes …
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Trend Analysis of Sub-Site Specific Primary Colorectal Cancer in One-Half Million Patients in the Surveillance, Epidemiology, and End Results Database, 1973-2007: Implications for Targeted Colonoscopy Screening
<p>Colorectal cancer is the third most common cancer and is the second cause of death from cancer. Recently, research suggests that there are differences in the incidence and mortality for cancers originating from the different locations of large intestine. Proximal cancers lag behind in terms of …
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Applications of quantitative phase imaging for pathology
Prostate cancers, which account for 14% of all cancers diagnosed in the United States, and colorectal cancers, which account for 8.2% of all cancers, present a unique set of diagnostic problems [1]. In the case of prostate cancer, overdiagnosis of early-stage disease and poor accuracy at …
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Study of Mutations and Expression of Genes Correlated to the Appearance of Colorectal Cancer /// Проучване на мутации и експресия на гени, корелиращи с изявата на колоректален карцином
… the previously mentioned signalling pathways in colorectal tumours. Tasks: • Analysis of the RAS oncogene mutational status and profile of patients’ colorectal cancer tumours. • Analysis of the expression levels of SIRT6, FOXO4 and HIF3A genes of all patients’ tumours compared to healthy colon …
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An investigation into the factors associated with psychological adjustment in men and women who have undergone surgery for colorectal cancer
Colorectal cancer is a major health problem for both men and women today. It is also lone of several site-specific cancers that patients are likely to survive beyondfive years of diagnosis. The majority of patients show good psychological adjustment following the diagnosis and treatment of …
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Defining the clinical importance of epithelial-stroma-immune signalling in colorectal cancer using a molecular pathology approach
… 20% of stage II and 36% of stage III colon cancer (CC) patients will experience disease relapse following surgery. Molecular and histological subtyping of CC has identified a poor-prognostic group of patients characterised by high levels of epithelial-to-mesenchymal transition (EMT) …
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Genetic Approach to Discover ARMC4 as a Novel NF-κB Negative Regulator and Tumor Suppressor in Colorectal Cancer
… in inflammatory and immune responses and in cancer. Therefore, understanding its regulation holds great promise for disease therapy. Using validation-based insertional mutagenesis (VBIM), a powerful technique established by us, we discovered armadillo repeat containing protein 4 (ARMC4) as a …
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Trends in Premature Mortality from Colorectal Cancer in the United States, 2000 to 2010
<p>Differences in colorectal cancer (CRC) incidence and mortality exist between men and women, different racial and ethnic groups, and geographical loci. However, little is known about the extent of premature death from CRC. This study investigates premature mortality as measured in years of …
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A Multi-Factorial Assessment of Partial Mitochondrial Complex I Impairment in Colorectal Cancer
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, yet the metabolic mechanisms that underlie its initiation and progression remain poorly defined. Mitochondrial metabolism, particularly the function of respiratory complex I, has emerged as a key determinant of …
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