Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Cancer cells Research"”.
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Translational development and mechanistic insights into 3-(4- hydroxyphenyl)indoline-2-ones as a potent class of breast cancer therapeutics
Cancer research and therapy have seen major developments in recent decades with the paradigm of surgery/radiotherapy/chemotherapy advancing towards selective small molecules, biologics, immunotherapy, and other targeted therapies. Small molecule drug development remains an important cornerstone of …
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Analysis of the aryl hydrocarbon receptor and a truncated form (AHR C[upper case symbol for greek Delta]Δ553) in cancer cells
… NFKB, whose activity is typically upregulated in cancer. This thesis focuses on using a truncated form of AhR, AhR CΔ553, which is thought to act as a dominant-negative to sequester Arnt from its other binding partners. To test this hypothesis, we transfected HeLa cells with AhR CΔ553 fused to …
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The role of epigenetic changes in chemoresistant breast cancer cells
… important in adjuvant treatment of breast cancer. Yet, tumours frequently acquire chemoresistance that correlates with increased aggressiveness and poor prognosis. Three theories exist describing how the resistance develops: genetic, epigenetic and karyotypic theory. The epigenetic theory …